A5030206682- Liver Disease Diagnosis and Treatment
- Microplastics and Plastic Pollution
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Long-Term Effects of COVID-19
- Recycling and Waste Management Techniques
- Tryptophan and brain disorders
- Pancreatitis Pathology and Treatment
- Hepatitis C virus research
- Effects and risks of endocrine disrupting chemicals
- Fibroblast Growth Factor Research
- Genomics, phytochemicals, and oxidative stress
- Healthcare and Environmental Waste Management
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Wnt/β-catenin signaling in development and cancer
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 and Mental Health
- Lipid metabolism and biosynthesis
- Diet and metabolism studies
- biodegradable polymer synthesis and properties
- Endoplasmic Reticulum Stress and Disease
- interferon and immune responses
- Inflammatory Biomarkers in Disease Prognosis
Institut d'Investigació Sanitària Pere Virgili
2022-2025
Universitat Rovira i Virgili
2022-2025
Agència de Gestió d'Ajuts Universitaris i de Recerca
2022-2024
Abstract Background and Aims The rise in obesity highlights the need for improved therapeutic strategies, particularly addressing metabolic dysfunction‐associated steatotic liver disease (MASLD). We aim to assess role of tryptophan pathways pathogenesis different histological stages MASLD. Materials Methods used ultra‐high performance liquid chromatography quantify circulating levels 15 tryptophan‐related metabolites from kynurenine, indole serotonin pathways. A cohort 76 subjects was...
Olfactomedins (OLFMs) are a family of glycoproteins that play relevant role in embryonic development and some pathological processes. Although OLFM2 is involved the regulation energy metabolism OLFM4 an important player inflammation, innate immunity cancer, OLFMs NAFLD-related intestinal dysbiosis remains unknown. In this study, we analysed hepatic mRNA expression jejunal well-established cohort women with morbid obesity (MO), classified according to their histology into normal liver (n =...
Abstract Background There is a lack of noninvasive diagnostic methods for nonalcoholic steatohepatitis (NASH), the severe condition metabolic dysfunction‐associated steatotic liver disease (MASLD). Platelet activation, evaluated through certain related parameters, associated with and inflammation, but previous results are inconclusive. Aim To investigate potential utility platelet‐related indices as markers detection prediction MASLD, focusing on NASH. Results We found that mean platelet...
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disease; nevertheless, no definitive diagnostic method exists yet, apart from invasive biopsy, and nor there a specific approved treatment. Runt-related transcription factor 1 (RUNX1) plays major role in angiogenesis inflammation; however, its link with NAFLD unclear as controversial results have been reported. Thus, objective of this work was to determine proteins involved molecular mechanisms between RUNX1...
The autophagy gene ATG7 has been shown to be essential for the induction of autophagy, a process that used suppressed in nonalcoholic fatty liver disease (NAFLD). However, specific role NAFLD remains unclear. aim this study was analyze hepatic mRNA and protein expression regarding obesity-associated NAFLD. Patients included women classified into normal weight (NW, n = 6) morbid obesity (MO, 72). second group subclassified (NL, 11), simple steatosis (SS, n= 29), steatohepatitis (NASH, 32)....
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disease. Although mostly benign, this can evolve into nonalcoholic steatohepatitis (NASH). The stimulator of interferon genes (STING) plays an important role in immune response against stressed cells, but protein may also be involved lipogenesis and microbiota composition. In study, STING NAFLD was evaluated by RT-qPCR to analyze mRNA abundance immunohistochemical analysis evaluate expression biopsies from a...
This study's objective was to assess the involvement of olfactomedin 2 (OLFM2), a secreted glycoprotein related lipid metabolism regulation, in nonalcoholic fatty liver disease (NAFLD) mediated by adipose-tissue-liver axis. OLFM2 mRNA expression analyzed subcutaneous (SAT) and visceral (VAT) adipose tissue RT-qPCR. The cohort included women with normal weight (n = 16) or morbid obesity (MO, n 60) who were subclassified into 20), simple steatosis 21), steatohepatitis (NASH, 19) groups....
Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipocytokine secreted by adipocytes that seems to be linked with nonalcoholic fatty liver disease (NAFLD). We aimed evaluate the role of SFRP5-wingless-MMTV integration site family member 5a (WNT5A) pathway, closely related adipogenesis, in subcutaneous (SAT) and visceral adipose tissues (VAT) its relationship obesity-related NAFLD. Our cohort was composed 60 women morbid obesity (MO), who underwent hypocaloric diet,...