A5073241369- Liver Disease Diagnosis and Treatment
- Paraoxonase enzyme and polymorphisms
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- SARS-CoV-2 and COVID-19 Research
- Metabolism, Diabetes, and Cancer
- Apelin-related biomedical research
- Chemokine receptors and signaling
- Pancreatitis Pathology and Treatment
- COVID-19 epidemiological studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Epigenetics and DNA Methylation
- Lipoproteins and Cardiovascular Health
- Galectins and Cancer Biology
- SARS-CoV-2 detection and testing
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Bariatric Surgery and Outcomes
- Cynara cardunculus studies
- Peripheral Artery Disease Management
- Biochemical Acid Research Studies
- Lung Cancer Treatments and Mutations
Hospital Universitari Sant Joan de Reus
2015-2024
Institut d'Investigació Sanitària Pere Virgili
2014-2023
Universitat Rovira i Virgili
2014-2023
The University of Texas Health Science Center at Houston
2023
Hospital Universitari Germans Trias i Pujol
2022
Spanish Ovarian Cancer Research Group
2022
Centro de Investigación Biomédica en Red
2013-2015
Hospital Universitari Joan XXIII de Tarragona
2014
Many countries have seen a two-wave pattern in reported cases of coronavirus disease-19 during the 2020 pandemic, with first wave spring followed by current second late summer and autumn. Empirical data show that characteristics effects virus do vary between two periods. Differences age range severity disease been reported, although comparative waves still remain largely unknown. Those are compared this study using from equal periods 3 half months. The period, 15 th March 30 June,...
Aging can be viewed as a quasi-programmed phenomenon driven by the overactivation of nutrient-sensing mTOR gerogene. mTOR-driven aging triggered or accelerated decline loss responsiveness to activation energy-sensing protein AMPK, critical gerosuppressor mTOR. The occurrence age-related diseases, therefore, reflects synergistic interaction between our evolutionary path sedentarism, which chronically increases number activating gero-promoters (e.g., food, growth factors, cytokines and...
Abstract Many countries have seen a two-wave pattern in reported cases of coronavirus disease-19 during the 2020 pandemic, with first wave spring followed by current second late summer and autumn. Empirical data show that characteristics effects virus do vary between two periods. Differences age range severity disease been reported, although comparative waves still remain largely unknown. Those are compared this study using from equal periods 3 half months. The period, 15 th March 30 June,...
Spain is one of the countries that has suffered most from impact severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), strain causes disease 2019 (COVID-19). However, there a lack information on characteristics this in Spanish population. The objective study been to characterize our patients an epidemiological point view and identify risk factors associated with mortality geographical area. We performed prospective, longitudinal 188 hospitalized cases SARS-Cov-2 infection Hospital...
9010 Background: Atezolizumab plus chemotherapy was safe and yielded promising clinical outcome as frontline therapy for patients (pts) with advanced NSCLC untreated brain metastases (BM) in the ATEZO-BRAIN study (NCT03526900). Methods: A multicenter single-arm phase II trial a Bayesian design evaluating safety efficacy of atezolizumab carboplatin pemetrexed every 3 weeks 4-6 cycles, followed by maintenance pts stage IV non-squamous without EGFR or ALK genetic alterations BM. Pts not...
Galectin-3 is a modulator of oxidative stress, inflammation, and fibrogenesis involved in the pathogenesis vascular diseases. The present study sought to characterize, patients with peripheral artery disease (PAD), localization galectin-3 arterial tissue, analyze relationships between circulating levels stress inflammation. It also compare diagnostic accuracy that other biochemical markers this disease. We analyzed femoral or popliteal arteries from 50 PAD patients, four control arteries....
The relevance of the association between inflammation and atrial fibrillation (AF) is not firmly established. clinical importance considerable because usually targeted as a treatment option, minimizing probable benefit.We have used case-control study with Mendelian randomization rationale to assess whether proposed risk factors that genetic component are readily detected in circulating blood causally related AF. studied variables were C-reactive protein (CRP) representative chemokine system,...
Abnormalities in mitochondrial metabolism and regulation of energy balance contribute to human diseases. The consequences high fat other nutrient intake, the resulting acquired dysfunction, are essential fully understand common disorders, including obesity, cancer, atherosclerosis. To simultaneously noninvasively measure quantify indirect markers function, we have developed a method based on gas chromatography coupled quadrupole-time flight mass spectrometry an electron ionization interface,...
Abstract Since the beginning of COVID-19 pandemic and until September 2021, Spain suffered five waves infection, latter being related to expansion Delta variant with a high incidence. A vaccination campaign began in December 2020 by end fifth wave 77.3% people had been fully vaccinated. Examining changing dynamics its impact on outcomes among those hospitalized is essential. Our objective was ascertain any differences characteristics patients during that period compared previous waves. We...
The acute multifunctional effects of polyphenols in humans.
Oxidative damage to lipids and lipoproteins is implicated in the development of atherosclerotic vascular diseases, including peripheral artery disease (PAD). The paraoxonases (PON) are a group antioxidant enzymes, termed PON1, PON2, PON3 that protect cells from peroxidation and, as such, may be involved protection against atherosclerosis process. PON1 inhibits production chemokine (C–C motif) ligand 2 (CCL2) endothelial incubated with oxidized lipoproteins. CCL2 ubiquitously distributed...
Summary Background Obesity can influence hepatic mitochondrial function, and cause non‐alcoholic steatohepatitis (NASH). Diagnosis follow‐up rely on invasive liver biopsy so blood‐based markers are urgently required. Aim To investigate whether values of circulating metabolites from energy one‐carbon (1‐C) metabolism may: (a) reflect flexibility failure (b) act as NASH biomarkers. Methods Patients with severe obesity undergoing bariatric surgery (n = 270) were investigated using quantitative...
Postprandial lipemia can lead to an accumulation of atherogenic lipoproteins in the circulation associated with systemic low-grade inflammation and increased risk cardiovascular disease. Lifestyle pharmacological treatments are usually prescribed for prevention. Vitamin D3 (cholecalciferol), as anti-atherogenic agent, is being taken into consideration due its potential beneficial effects lipid metabolism anti-inflammatory potency. To assess vitamin postprandial profile obese, D-deficient...
SARS-CoV-2 infection produces a response of the innate immune system causing oxidative stress and strong inflammatory reaction termed ‘cytokine storm’ that is one leading causes death. Paraoxonase-1 (PON1) protects against by hydrolyzing lipoperoxides. Alterations in PON1 activity have been associated with pro-inflammatory mediators such as chemokine (C-C motif) ligand 2 (CCL2), glycoprotein galectin-3. We aimed to investigate alterations circulating levels PON1, CCL2, galectin-3 126...
Prevention of the metabolic consequences a chronic energy-dense/high-fat diet (HFD) represents public health priority. Metformin is strong candidate to be incorporated in alternative therapeutic approaches. We used targeted metabolomic approach assess changes related multi-faceted disturbances provoked by HFD. evaluated protective effects metformin and explored how pro-inflammatory respond when mice rendered obese, glucose-intolerant hyperlipidemic were switched reversal with or without...