Simona Iftimie
A5056144784- COVID-19 Clinical Research Studies
- Paraoxonase enzyme and polymorphisms
- Pancreatitis Pathology and Treatment
- Metabolomics and Mass Spectrometry Studies
- Antimicrobial Resistance in Staphylococcus
- Nosocomial Infections in ICU
- SARS-CoV-2 and COVID-19 Research
- Central Venous Catheters and Hemodialysis
- Cardiac, Anesthesia and Surgical Outcomes
- Bacterial Identification and Susceptibility Testing
- Surgical site infection prevention
- Antibiotic Resistance in Bacteria
- Streptococcal Infections and Treatments
- Apelin-related biomedical research
- COVID-19 epidemiological studies
- Antibiotics Pharmacokinetics and Efficacy
- Vitamin C and Antioxidants Research
- Antibiotic Use and Resistance
- Cynara cardunculus studies
- Long-Term Effects of COVID-19
- Colorectal Cancer Surgical Treatments
- Advanced Chemical Sensor Technologies
- Liver Disease Diagnosis and Treatment
- Urinary Tract Infections Management
- Infective Endocarditis Diagnosis and Management
Institut d'Investigació Sanitària Pere Virgili
2016-2025
Universitat Rovira i Virgili
2016-2025
Hospital Universitari Sant Joan de Reus
2010-2025
Reig Jofre (Spain)
2017
Universidad de Sevilla
2014
Hospital Universitario Virgen Macarena
2014
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2010
Many countries have seen a two-wave pattern in reported cases of coronavirus disease-19 during the 2020 pandemic, with first wave spring followed by current second late summer and autumn. Empirical data show that characteristics effects virus do vary between two periods. Differences age range severity disease been reported, although comparative waves still remain largely unknown. Those are compared this study using from equal periods 3 half months. The period, 15 th March 30 June,...
Abstract Many countries have seen a two-wave pattern in reported cases of coronavirus disease-19 during the 2020 pandemic, with first wave spring followed by current second late summer and autumn. Empirical data show that characteristics effects virus do vary between two periods. Differences age range severity disease been reported, although comparative waves still remain largely unknown. Those are compared this study using from equal periods 3 half months. The period, 15 th March 30 June,...
BackgroundTreatment of multidrug-resistant Acinetobacter baumannii (MDRAB) infection presents a challenge because the scarcity available options. Even though combination therapy (CT) is frequently used in clinical practice, data are needed to support its use instead monotherapy (MT).
Abstract Objectives To analyse the effectiveness of dalbavancin (DBV) in clinical practice as consolidation therapy patients with bloodstream infection (BSI) and/or infective endocarditis (IE) produced by gram-positive cocci (GPC), well its safety and pharmacoeconomic impact. Methods A multicentre, observational retrospective study was conducted hospitalised IE BSI GPC who received at least one dose DBV. Clinical response assessed during hospitalization, 3 months 1 year. Results Eighty-three...
The objective of this study was to analyse whether there is an association between reduced susceptibility biocides in Acinetobacter baumannii and (i) antimicrobial resistance (co-resistance), (ii) prevalent (epidemic) clones, (iii) changes the fitness or (iv) expression genes related efflux pumps porins. Susceptibility antimicrobials determined 49 clonally unrelated isolates A. baumannii. Biological cost, terms mean generation time, by spectrophotometry. Quantitative real-time RT–PCR used...
Spain is one of the countries that has suffered most from impact severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), strain causes disease 2019 (COVID-19). However, there a lack information on characteristics this in Spanish population. The objective study been to characterize our patients an epidemiological point view and identify risk factors associated with mortality geographical area. We performed prospective, longitudinal 188 hospitalized cases SARS-Cov-2 infection Hospital...
Viral infections cause metabolic dysregulation in the infected organism. The present study used metabolomics techniques and machine learning algorithms to retrospectively analyze alterations of a broad panel metabolites serum urine cohort 126 patients hospitalized with COVID-19. Results were compared those 50 healthy subjects 45 COVID-19-negative but bacterial infectious diseases. Metabolites analyzed by gas chromatography coupled quadrupole time-of-flight mass spectrometry. main altered...
Treatment failure occurs in about 25% of patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. We assessed whether cloxacillin plus fosfomycin achieves better treatment success than alone hospitalized adults MSSA conducted a multicenter, open-label, phase III-IV superiority randomized clinical trial. randomly assigned (1:1) to receive 2 g intravenous every 4 h or 3 6 for the initial 7 days. The primary endpoint was at day 7, composite following criteria: patient...
This prospective observational study compared the 1H NMR blood lipidomes and metabolomes of 71 patients with community-acquired pneumonia (CAP), 75 COVID-19 pneumonia, healthy controls (matched by age sex) to identify potential biomarkers pathways associated respiratory infections. Both groups had comparable severity indices, including mortality, invasive mechanical ventilation, intensive care unit admission rates. Patients exhibited more pronounced hypolipidemia, significantly lower levels...
BackgroundCarbapenem-resistant Acinetobacter baumannii (CRAb) is a major source of nosocomial infections in Spain associated with the production OXA-58-like or OXA-24/40-like β-lactamase enzymes. We analysed plasmids carrying blaOXA-24/40-like gene CRAb isolates obtained decade apart.
Abstract Since the beginning of COVID-19 pandemic and until September 2021, Spain suffered five waves infection, latter being related to expansion Delta variant with a high incidence. A vaccination campaign began in December 2020 by end fifth wave 77.3% people had been fully vaccinated. Examining changing dynamics its impact on outcomes among those hospitalized is essential. Our objective was ascertain any differences characteristics patients during that period compared previous waves. We...
.Background: Clostridioides difficile infections (CDI) vary in severity from mild diarrhea to life-threatening conditions like pseudomembranous colitis or toxic megacolon, often leading sepsis and death. The COVID-19 pandemic prompted changes healthcare practices, potentially affecting CDI incidence, though reported data are inconclusive. We studied factors influencing incidence outcomes at a university hospital throughout the years. Methods: conducted retrospective study on all adult...
Abstract Background There is controversy regarding the maximum number of elements that can be included in a surgical site infection prevention bundle. In addition, it unclear whether bundle this type implemented at multicentre level. Methods A pragmatic, cohort study was designed to analyse rates elective colorectal surgery after sequential implementation two preventive protocols. Secondary outcomes were determine compliance with individual measures and establish their effectiveness,...
Urinary tract infections (UTIs) are a significant global health issue, especially among women, with growing concerns related to antibiotic resistance and adverse effects. The Uromune®, sublingual, heat-inactivated, polybacterial vaccine, represents promising therapeutic alternative by enhancing immune responses against uropathogens. This pilot retrospective study, conducted at Hospital Universitari de Sant Joan Reus from January 2018 August 2022, assessed the association between Uromune®...
HDL particles may act to buffer host cells from excessive inflammatory mediators. The aim of this study is investigate if the lipid profile provides a prognostic biomarker for COVID-19 outcomes.This was prospective characteristics 125 adult patients with performed on day admission analyzed regard clinical outcomes.Seventy-seven (61.2%) were men, mean age 66.3 (15.6) years. 54.1% had bilateral pneumonia. all-cause mortality rate during hospitalization 20.8%. We found direct association...