A5007710630- HIV Research and Treatment
- HIV-related health complications and treatments
- Paraoxonase enzyme and polymorphisms
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Apelin-related biomedical research
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Clusterin in disease pathology
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Lipid metabolism and disorders
- Long-Term Effects of COVID-19
- Chemokine receptors and signaling
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Cell Function and Interaction
- Metabolomics and Mass Spectrometry Studies
- Pancreatitis Pathology and Treatment
- Cynara cardunculus studies
- Diabetes and associated disorders
Universitat Rovira i Virgili
2014-2025
Institut d'Investigació Sanitària Pere Virgili
2014-2025
Instituto de Salud Carlos III
2021-2025
Centro de Investigación Biomédica en Red
2013-2025
Hospital Universitari Joan XXIII de Tarragona
2017-2024
Hospital de Sant Pau
2014-2021
Hospital Universitari Sant Joan de Reus
2005-2012
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2010
Nonalcoholic fatty liver disease is considered to be the hepatic manifestation of metabolic syndrome and usually related high-fat, high-cholesterol diets. With rationale that identification quantification metabolites in different pathways may facilitate discovery clinically accessible biomarkers, we report use 1H NMR metabolomics for quantitative profiling extracts from LDLr−/− mice, a well-documented mouse model disease. A total 55 were identified, multivariate analyses diet-...
Aging can be viewed as a quasi-programmed phenomenon driven by the overactivation of nutrient-sensing mTOR gerogene. mTOR-driven aging triggered or accelerated decline loss responsiveness to activation energy-sensing protein AMPK, critical gerosuppressor mTOR. The occurrence age-related diseases, therefore, reflects synergistic interaction between our evolutionary path sedentarism, which chronically increases number activating gero-promoters (e.g., food, growth factors, cytokines and...
To maintain homeostasis under diverse metabolic conditions, it is necessary to coordinate nutrient-sensing pathways with the immune response. This coordination requires a complex relationship between cells, hormones, and cytokines in which inflammatory are convergent at multiple levels. Recruitment of macrophages metabolically compromised tissue primary event chemokines play crucial role. However, may also transmit cell signals that generate responses, most unrelated chemotaxis, involved...
Background: Persistent controllers (PC) maintain antiretroviral-free HIV-1 control indefinitely over time while transient (TC) eventually lose virological control. It is essential to characterize the quality of HIV reservoir these phenotypes identify factors that lead progression and open new avenues in cure strategies. Methods: The characterization reservoir, from peripheral blood mononuclear cells, was performed using next-generation sequencing techniques, such as full-length individual...
Abstract Background Paraoxonase-1 (PON1) is an antioxidant enzyme synthesized by the liver. It protects against liver impairment and attenuates production of pro-inflammatory monocyte chemoattractant protein-1 (MCP-1). We investigated relationships between hepatic PON1 MCP-1 expression in rats with disease explored possible molecular mechanisms involved. Methods CCl 4 was administered for up to 12 weeks induce damage. Serum levels MCP-1, their gene protein expression, nuclear transcription...
HIV-infected patients show an increased cardiovascular disease (CVD) risk resulting, essentially, from metabolic disturbances related to chronic infection and antiretroviral treatments. The aims of this study were: (1) evaluate the agreement between CVD estimated using Framingham score (FRS) observed presence subclinical atherosclerosis in patients; (2) investigate relationships plasma biomarkers oxidation inflammation.Atherosclerosis was evaluated 187 by measuring carotid intima-media...
Oxidative stress is a determinant of liver steatosis and the progression to more severe forms disease. The present study investigated effect paraoxonase-1 (PON1) deficiency on histological alterations hepatic metabolism in mice fed high-fat high-cholesterol diet. We performed nontargeted metabolomics tissues from 8 male PON1-deficient wild-type animals high-fat, diet for 22 weeks. also measured 8-oxo-20-deoxyguanosine, reduced oxidized glutathione, malondialdehyde, 8-isoprostanes protein...
Hypertension is one of the most common risk factors for COVID-19 clinical progression. The identification plasma biomarkers anticipating worse outcomes and to better understand shared mechanisms between hypertension are needed. A hypothesis-generating study was designed compare proteomics metabolomics 22 hypertensives (HT) 41 non-hypertensives (nHT) patients with unfavorable total 43 molecules were significantly differed HT (n = 22) nHT 41). Random Forest (RF) analysis identified...
Eur J Clin Invest 2011; 41 (3): 308–314 Abstract Background The paraoxonase (PON) enzyme family comprising PON1, PON2 and PON3 are antioxidant enzymes that degrade bioactive oxidised lipids thus antiatherogenic. Materials methods We investigated the localisation of PON proteins during development atherosclerosis by immunohistochemical analysis. Results In normal aortas, PON1 were localised to smooth muscle cells (SMC) endothelial cells. staining was stronger than PON1. During development,...
The paraoxonase (PON) group of enzymes, composed PON1, PON2, and PON3, play an important role in decreasing oxidative stress by degrading lipid peroxides. PON1 synthesis is upregulated PPAR. Several pharmacological compounds (acting as antioxidants and, hence, atheroprotective) stimulate both PPAR activity expression. Recent evidence suggests that the monocyte chemoattractant protein-1 (MCP-1) are involved coordinating inflammatory response damaged tissues; may be central regulation these...
Peroxisome proliferator-activated receptors (PPAR) play an important role in the regulation of lipid and glucose metabolism, inflammatory, vascular responses. We show effect treatment with two PPAR agonists, fenofibrate (FF) rosiglitazone (RSG), on ob/ob LDLR-double deficient mice, by combined gene-expression metabolomic analyses. Male mice were daily treated for 12 weeks RSG (10 mg·kg1–·day–1 per os (p.o.), n = 8) FF (50 p.o., 8). Twelve untreated used as controls. To integrate...
The cytokine signature present in COVID-19 could provide information on the pathogenic mechanisms of disease and identify possible prognostic biomarkers therapeutic targets. In this longitudinal work, we studied clinical biochemical parameters circulating levels 146 patients at time admission for 4-6 weeks later. main objective study was to determine whether basal cytokines be early COVID-19, also analyze impact comorbidities, such as obesity or metabolic syndrome (MS), profile. most...