A5060467685- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cholesterol and Lipid Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Lipoproteins and Cardiovascular Health
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Drug Transport and Resistance Mechanisms
- Antioxidant Activity and Oxidative Stress
- Fatty Acid Research and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Steroid Chemistry and Biochemistry
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Gut microbiota and health
- Edible Oils Quality and Analysis
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Biology and Fertility
- Phytochemicals and Antioxidant Activities
- Reproductive Health and Technologies
- Aortic aneurysm repair treatments
- Ovarian function and disorders
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2015-2025
Institut d'Investigació Sanitària Pere Virgili
2022-2025
Instituto de Salud Carlos III
2017-2025
Institut d'Investigacions Biomèdiques de Barcelona
2014-2023
Hospital Universitari Joan XXIII de Tarragona
2023
Hospital de Sant Pau
2013-2020
Universitat Autònoma de Barcelona
2014-2020
Augusta University
2017-2020
Centro Nacional de Microbiologia
2019
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019
Abstract Background Succinate is produced by both human cells and gut bacteria couples metabolism to inflammation as an extracellular signaling transducer. Circulating succinate elevated in patients with obesity type 2 diabetes linked numerous complications, yet no studies have specifically addressed the contribution of microbiota systemic or explored consequences reducing intestinal levels this setting. Results Using germ-free microbiota-depleted mouse models, we show that a significant...
The very low-density lipoprotein receptor (VLDLR) plays an important role in the development of hepatic steatosis. In this study, we investigated Peroxisome Proliferator-Activated Receptor (PPAR)β/δ and fibroblast growth factor 21 (FGF21) VLDLR regulation.Studies were conducted wild-type Pparβ/δ-null mice, primary mouse hepatocytes, human Huh-7 liver biopsies from control subjects patients with moderate severe steatosis.Increased levels observed mice Pparβ/δ-knocked down hepatocytes through...
To determine if maternal major depression (MD), antidepressant use, or paternal MD are associated with pregnancy outcomes after non-IVF fertility treatments.Cohort study.Clinics.Participants in two randomized trials: PPCOS II (clomiphene citrate versus letrozole for polycystic ovary syndrome), and AMIGOS (gonadotropins clomiphene unexplained infertility).Female male partners completed the Patient Health Questionnaire (PHQ-9). Female medication use was collected. PHQ-9 score ≥10 used to...
The HDL (high-density lipoprotein)-mediated stimulation of cellular cholesterol efflux initiates macrophage-specific reverse transport (m-RCT), which ends in the fecal excretion macrophage-derived unesterified (UC). Early studies established that LDL (low-density lipoprotein) particles could act as efficient intermediate acceptors cellular-derived UC, thereby preventing saturation and facilitating their capacity. However, capacity to a plasma reservoir its potential impact supporting m-RCT...
Background Although there are successful examples of the discovery new PPARγ agonists, it has recently been great interest to identify partial agonists that do not present adverse side effects caused by full agonists. Consequently, goal this work was design, apply and validate a virtual screening workflow novel among natural products. Methodology/Principal Findings We have developed procedure based on structure-based pharmacophore construction, protein-ligand docking electrostatic/shape...
The aim of the present study was to determine effects a cafeteria diet on function and apoptosis pancreas, activity expression insulin-degrading enzyme (IDE). Female Wistar rats were fed either with or control for 17 weeks, blood tissues then collected analysis. diet-treated had higher plasma insulin C-peptide levels (P<0·05), showing increased secretion by pancreas. Insulin protein gene in pancreas obese rats, as its transcriptional controller, pancreatic duodenal homeobox 1 (P<0·05)....
Liver X receptors (LXR) are transcription factors from the nuclear receptor family that activated by oxysterols and synthetic high-affinity agonists. In this study, we assessed antitumor effects of LXR agonist TO901317 in a murine model syngeneic Lewis Lung carcinoma. Treatment with inhibited tumor growth wild-type, but not LXR-deficient mice, indicating depends on functional activity host cells. Pharmacologic activation pathway reduced intratumoral abundance regulatory T cells (Treg)...
Macrophages play an important role in immunogenic challenges by producing reactive oxygen species, NO and proinflammatory cytokines that can aggravate propagate local inflammation. Multiple mechanisms regulate these inflammatory processes. NF-κB activator protein 1 pathways are crucial the expression of genes, such as TNF-α, IL-1 (α or β) -6. Some polyphenols, which present beverages, vegetables fruits, PUFA, marine oils fish food, possess anti-inflammatory effects vivo vitro . Our aim study...
To identify baseline characteristics of women with unexplained infertility to determine whether treatment an aromatase inhibitor will result in a lower rate multiple gestations than current standard ovulation induction medications.Randomized, prospective clinical trial.Multicenter university-based practices.A total 900 couples infertility.Collection demographics, blood samples, and ultrasonographic assessments.Demographic, laboratory, imaging, survey characteristics.Demographic receiving...
Procyanidins modulate glucose metabolism, partly due to its effects on pancreas. Given the role of microRNAs (miRNAs) in regulation diabetes and fact that flavonoids miRNAs other tissues, we hypothesized procyanidins might target We investigated miRNA expression profile pancreatic islets isolated from rats treated with a daily dose grape seed procyanidin extract (GSPE) (25 mg/kg body weight) for 45 days. The miRWalk database identified putative genes these miRNAs. found GSPE altered...
Abstract Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies reported contradictory results regard to the relationship between apolipoprotein (apo) A-I and cancer. We aimed determine effects human apoA-I overexpression administration specific mimetic peptide (D-4F) on tumour progression by using mammary virus-polyoma middle T-antigen transgenic (PyMT) mice as a model inherited Expression in did not affect...
Hypertension is one of the most common risk factors for COVID-19 clinical progression. The identification plasma biomarkers anticipating worse outcomes and to better understand shared mechanisms between hypertension are needed. A hypothesis-generating study was designed compare proteomics metabolomics 22 hypertensives (HT) 41 non-hypertensives (nHT) patients with unfavorable total 43 molecules were significantly differed HT (n = 22) nHT 41). Random Forest (RF) analysis identified...