A5045890454- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Metabolism, Diabetes, and Cancer
- Regulation of Appetite and Obesity
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Growth Hormone and Insulin-like Growth Factors
- Adipose Tissue and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Celiac Disease Research and Management
- Genetic factors in colorectal cancer
- Endoplasmic Reticulum Stress and Disease
- Vitamin D Research Studies
- Microscopic Colitis
- Atherosclerosis and Cardiovascular Diseases
- Gastrointestinal disorders and treatments
- Digestive system and related health
- Liver Diseases and Immunity
- Ovarian function and disorders
- Salmonella and Campylobacter epidemiology
- Pancreatic function and diabetes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Hernia repair and management
- Kruppel-like factors research
- Hypothalamic control of reproductive hormones
Semnan University of Medical Sciences
2014-2024
Kowsar Hospital
2017-2023
Semnan University
2015
Shahid Beheshti University of Medical Sciences
2012-2014
The very low-density lipoprotein receptor (VLDLR) plays an important role in the development of hepatic steatosis. In this study, we investigated Peroxisome Proliferator-Activated Receptor (PPAR)β/δ and fibroblast growth factor 21 (FGF21) VLDLR regulation.Studies were conducted wild-type Pparβ/δ-null mice, primary mouse hepatocytes, human Huh-7 liver biopsies from control subjects patients with moderate severe steatosis.Increased levels observed mice Pparβ/δ-knocked down hepatocytes through...
Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), therefore vitamin receptor (VDR), parathyroid hormone (PTH), (INSR) gene variants might be involved the pathogenesis of PCOS.The present study was designed investigate possible associations between polymorphisms VDR, PTH, INSR genes risk PCOS.VDR, were genotyped 35 women with PCOS controls using Polymerase chain reaction - Restriction fragment length polymorphism method. Furthermore, serum...
Purposes Obesity is associated with an increased risk of colorectal cancer (CRC), and ghrelin (GHRL) resistin (RETN) are thought to be related obesity. Our aim was investigate whether GHRL RETN gene variants CRC risk. Materials Methods All 414 subjects, including 197 cases 217 controls, were genotyped for the (rs26802) (rs1862513) or -420C>G using PCR-RFLP method. Results findings indicated that “CC” genotype, compared “GG” “GC” genotypes, a marker decreased susceptibility; difference...
Given the role of insulin resistance in colorectal cancer (CRC), we explored whether genetic variants (INS), receptor (INSR), substrate 1 (IRS1), 2 (IRS2), insulin-like growth factor (IGF1), and binding protein 3 (IGFBP3) genes were associated with CRC risk. A total 600 subjects, including 261 cases 339 controls, enrolled this case-control study. Six polymorphisms INS (rs689), INSR (rs1799817), IRS1 (rs1801278), IRS2 (rs1805097), IGF1 (rs5742612), IGFBP3 (rs2854744) genotyped using PCR-RFLP...
Colorectal cancer (CRC) is the second most commonly diagnosed and fourth leading cause of cancer-related mortality around world.With regard to role obesity in colorectal leptin obesity, we investigated whether (LEP) receptor (LEPR) gene variants are associated with CRC risk.We evaluated LEP (rs7799039) LEPR (rs1137101) by using PCR-RFLP method 261 cases 339 controls.No significant difference was found for rs7799039 rs1137101gene between controls. However, rs1137101 "GG" genotype compared...
ABSTRACT BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is an increasing global health concern defined by excessive hepatic fat content in the absence of alcohol consumption. OBJECTIVE: Given pivotal role insulin resistance NAFLD, we hypothesized that (INS) and receptor (INSR) gene polymorphisms may be associated with NAFLD risk. METHODS: A total 312 subjects, including 153 cases biopsy-proven 159 controls were enrolled this case-control study. Four INS (rs3842752, rs689) INSR...
Several epidemiological studies have shown associations between colorectal cancer (CRC) risk and type 2 diabetes obesity. Any effects would be expected to mediated through the insulin pathway. Therefore it is possible that variants of genes encoding components pathway play roles in CRC susceptibility. In this study, we hypothesized polymorphisms involving are associated with CRC.The four single nucleotide (SNPs) IGF-I (rs6214), IGFBP-3 (rs3110697), INSR (rs1052371), IRS2 (rs2289046) were...
Background Given the major role of obesity and insulin resistance (IR) in colorectal cancer (CRC), we investigated whether genetic variants ghrelin ( GHRL), resistin RETN) receptor substrate 1 IRS1) were associated with CRC risk. Methods This study was conducted as a case-control study, 750 subjects, including 438 controls 312 patients CRC, enrolled genotyped using PCR-RFLP method. Results No significant differences observed for GHRL (rs696217), RETN (rs3745367) IRS1 (rs1801278, Gly972Arg or...
Background: Substantial evidence from epidemiological studies has suggested that increased levels of calcium may play a protective role against colorectal cancer (CRC). Given the vital sensing receptor (CaSR) and parathyroid hormone (PTH) in maintenance homeostasis, we explored whether rs1801725 (A986S) variant located exon 7 CaSR gene rs6256 3 PTH might be associated with CRC risk. Materials Methods: In this study 860 subjects including 350 cases 510 controls were enrolled genotyped using...
With regard to the protective effect of vitamin D against colorectal cancer (CRC), we evaluated genetic variants that might influence metabolism: receptor (VDR), binding protein (GC), 25-hydroxylase (CYP2R1), and 25-hydroxy 1-alpha hydroxylase (CYP27B1).A total 657 subjects, including 303 cases with CRC 354 controls were enrolled in this case-control study. All genotyped for four gene using PCR-RFLP methods.In study, no significant difference was observed VDR (rs2238136), GC (rs4588), CYP2R1...
Regarding the central role of insulin resistance in NAFLD, we explored whether insulin-like growth factor 1 (IGF1) and factor-binding protein 3 (IGFBP3) gene variants were associated with NAFLD susceptibility.IGF1 (rs6214) IGFBP3 (rs3110697) genotyped 154 cases biopsy-proven 156 controls using PCR-RFLP method.The IGF1 rs6214 "AA + AG" genotype compared "GG" appeared to be a marker decreased susceptibility (p = .006; OR 0.47, 95%CI 0.28-0.80). Furthermore, "A" allele was underrepresented than...
Background: Considering the role of visfatin in nonalcoholic fatty liver disease (NAFLD), a growing global epidemic, this article explores potential association between gene (NAMPT) and NAFLD. Methods: We used PCR-restriction fragment length polymorphism method to genotype rs1319501 promoter variant NAMPT 154 patients with biopsy-proven NAFLD 158 controls case–control genetic study. Results: The 'CC+TC' comparison 'TT' occurred less frequently cases than controls, difference remained...
Nonalcoholic fatty liver disease (NAFLD) is an emerging global chronic worldwide. Considering the powerful association between NAFLD, insulin resistance (IR) and obesity, as well key role of ghrelin in these metabolic disorders, we hypothesized that some single nucleotide polymorphisms (SNPs) (GHRL) receptor (GHSR) genes might be associated with NAFLD.We conducted a case-control retrospective study 150 cases biopsy-proven NAFLD 155 controls. The diagnosis was established before start...
Nonalcoholic fatty liver disease (NAFLD) is a chronic and growing global epidemic. In NAFLD, fat surpasses 5% of hepatocytes without the secondary causes lipid accumulation or excessive alcohol consumption. Given link between NAFLD insulin resistance, possible association rs2854744 (-202 G>T) promoter polymorphism insulin-like growth factor binding protein 3 (
Objectives: The aim of this study was to evaluate the effect silymarin on liver enzyme levels and serum lipid profiles in patients with Non-Alcoholic Fatty Liver Disease (NAFLD), most common chronic disease worldwide. Methods: This randomized double-blinded clinical trial included 80 NAFLD referred gastrointestinal clinic Kowsar Hospital Semnan. Forty these were supplemented 150 mg twice a day for two months, while other 40 received placebo. Both groups advised follow hypertriglyceridemia...
The pancreatic neuroendocrine tumor (pNET) is relatively rare and generally felt to follow an indolent course. EUS has important role in detection of pNET. This a review clinical radiological presentation pathologic reports 22 patients with pNET.In this study we analyzed presentations all relevant cases who were referred Taleghani hospital for 3 years since 2008.A total 28-74 old (mean=49) enrolled between 2008 2011. Among the total, 13 (59%) male, 9 (41%) female 16 (72.7%) had functional...
Nonalcoholic fatty liver disease (NAFLD) is a growing problem and the commonest cause of chronic throughout world. Given strong association between NAFLD insulin resistance obesity, as well central role ghrelin in these metabolic disorders, we explored whether (GHRL) receptor (GHSR) gene polymorphisms were associated with susceptibility to NAFLD.In this case-control retrospective study which was conducted April 2010 July 2013, GHRL (rs696217 or Leu72Met) GHSR (rs2922126) genotyped 153 cases...
Abstract Background Given that obesity and insulin resistance play key roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) connection between leptin these metabolic diseases, association NAFLD a receptor gene (LEPR) polymorphism was examined. Methods In this genetic case-control study, 144 biopsy-proven patients controls were genotyped for LEPR Gln223Arg (rs1137101) using polymerase chain reaction–restriction fragment length method. Results The distributions genotypes...
SUMMARY OBJECTIVES: Nonalcoholic fatty liver disease is the term used for a range of conditions in which fat builds up and exceeds 5% hepatocytes without inordinate alcohol intake or other causes lipid accumulation. Regarding fact that insulin resistance obesity play key roles pathogenesis nonalcoholic disease, as well connection between resistin these metabolic diseases, association gene (RETN) polymorphism was examined. METHODS: In this genetic case–control study, 150 biopsy-proven...
The aim of this study was to investigate the relation between Celiac disease (CD) and unexplained dysfunctional uterine bleeding (DUB) in celiac women.The patients were selected from women who referred department.Controls those without any signs matched with age.Meanwhile, a trained physician ready explain study, then case their allowance, questionnaire completed by physician.24 % reported past history at least one menstrual cycle disorder vs 10 controls these problems (p=0.038)and higher...
ABSTRACT BACKGROUND AND OBJECTIVE: Considering the association between colorectal cancer (CRC) and both insulin resistance obesity, prominent role of ghrelin in these metabolic disorders, we explored whether plasma levels were associated with CRC. Moreover, patients CRC possible correlations insulin, resistance, body mass index (BMI) as an indicator obesity examined. METHODS: A total 170 subjects, including 82 cases 88 controls enrolled this study. Plasma ghrelin, glucose measured all...