A5021851171- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- Hepatitis C virus research
- Congenital Heart Disease Studies
- Long-Term Effects of COVID-19
- Infective Endocarditis Diagnosis and Management
- Coronary Artery Anomalies
- Bacillus and Francisella bacterial research
- Congenital Anomalies and Fetal Surgery
- Liver Disease Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
- Health disparities and outcomes
- Herpesvirus Infections and Treatments
- Medication Adherence and Compliance
- Clostridium difficile and Clostridium perfringens research
- Poxvirus research and outbreaks
- Parasites and Host Interactions
- Cytomegalovirus and herpesvirus research
- COVID-19 Impact on Reproduction
Hospital Clínico Universitario Virgen de la Victoria
2020-2025
Instituto de Investigación Biomédica de Málaga
2021-2025
Instituto de Salud Carlos III
2023
Centro de Investigación Biomédica en Red
2023
Hospital Universitario Ramón y Cajal
2019-2020
Instituto Ramón y Cajal de Investigación Sanitaria
2012-2019
Instituto Cajal
2019
Hospital Universitario Príncipe de Asturias
2009
Background: Persistent controllers (PC) maintain antiretroviral-free HIV-1 control indefinitely over time while transient (TC) eventually lose virological control. It is essential to characterize the quality of HIV reservoir these phenotypes identify factors that lead progression and open new avenues in cure strategies. Methods: The characterization reservoir, from peripheral blood mononuclear cells, was performed using next-generation sequencing techniques, such as full-length individual...
Abstract To date, former research about the impact of HIV infection on mpox poor outcomes is still limited and controversial. Therefore, aim this study was to assess clinical course mpox, in a large population patients from Spain. Nationwide case‐series study. Patients 18 Spanish hospitals, with PCR‐confirmed April 27, 2022 June 30, 2023 were included The main outcome development long or complicated (LC) defined as: (i) duration ≥ 28 days, or; (ii) disseminated disease, or: (iii) emergence...
Abstract Background Prior analyses suggest nucleoside reverse transcriptase inhibitor (NRTI) abacavir (ABC), but not tenofovir (TFV), is associated with a 2-fold increase in the hazard of myocardial infarction. REPRIEVE ideally suited to evaluate role ABC and TFV backbones, alafenamide (TAF) disoproxil fumarate (TDF), major adverse cardiovascular events (MACE). Methods We compared first MACE among people HIV (PWH) at low-to-moderate risk using (n=883), TAF (n=957), TDF (n=4274) entry....
Introduction HIV testing guidelines are poorly implemented in most clinical settings. The best screening strategy and healthcare scenario still unknown. aim of our study is to evaluate the impact a structured intervention (DRIVE), compared as routinely performed practice, two different settings: primary care center an emergency department. Methods Prospective evaluation settings from same area. DRIVE program included trained nurse practitioners perform screening, questionnaire assess risk...
The aim of our study was to develop a Spanish-structured HIV risk exposure and indicator conditions (RE&IC) questionnaire. People attending an emergency room or primary clinical care center were offered participate in prospective, 1 arm, open label study, which all enrolled patients filled out developed questionnaire tested. Questionnaire accuracy, feasibility, reliability evaluated. Valid paired 5329 RE&IC rapid tests performed, 69.3% the center, 49.6% women, median age 37 years old, 74.9%...
Objectives Spain is close to HCV microelimination, so rates of recently acquired infection (RAHC) should decrease. Nowadays, men who have sex with (MSM) carry the highest risk acquisition. Our aim was estimate incidence and factors associated RAHC, together reinfection rates, among patients sexually infected by HIV. Methods Primary RAHC diagnosed when anti‐HCV antibody seroconversion documented. In positive patients, initially without viraemia, a diagnosis established if plasma RNA detected....
Abstract Background Patterns of antiretroviral therapy (ART) use and immunologic correlates vary globally, contemporary trends are not well described. Methods The REPRIEVE trial (Randomized Trial to Prevent Vascular Events in HIV) enrolled persons with human immunodeficiency virus (HIV) who were aged 40–75 years, receiving ART, had low-to-moderate cardiovascular disease risk. ART was summarized within Global Burden Disease (GBD) super-regions, adjusted linear logistic regression analyses...
Abstract Hepatitis C virus (HCV) and HIV are major causes of worldwide disease. We aimed to evaluate the effect a combined screening programme, which included risk‐assessment questionnaire rapid tests for point‐of‐care diagnosis, on new diagnosis rates. This prospective, cluster randomized study was carried out in primary care. The intervention arm 4‐hour educational use tests. In control centres, only provided. main variables compared were coverage number rate HCV diagnoses. Of total 7991...
Abstract Introduction Dolutegravir/rilpivirine (DTG/RPV) is an effective antiretroviral (ART) regimen endorsed by clinical trials as a switch therapy. The aim of our study was to analyse the efficacy and safety DTG/RPV in real‐world practice. Methods Observational, multicentre patients who started DTG/RPV. Efficacy, adverse events metabolic changes at 48 weeks were analysed. Results A total 348 included; median time HIV infection 21.1 years, 33.7% AIDS cases; nadir CD4 160 cells/μL; 90.5%...
Background Cofactors associated with persistently abnormal CD4 + :CD8 T-cell ratio in people HIV (PWH) on antiretroviral treatment (ART) might change over time as the population of ages or new ART drugs become available. The main objective our study was to determine long-term associations baseline factors, including count and ratio, normalization (≥1). In addition this, we explored whether remained risk both AIDS non-AIDS events among individuals suppressive ART. Methods Clinic-based a...
Different HIV Testing Strategies (TS) and clinical care settings had not been face to evaluated (1). We compared coverage, Newly Diagnosed Infection (NDHI) Estimated Missing Infections (MHI) in Hospital Emergency Room (HER) Primary Care Center (PCC), DRIVE study (Spanish acronym of infection Rapid Diagnosis) practice the year before DRIVE.In study, 18-60 years old, non-HIV-infected population visiting an HER or a PCC were proposed both structured risk practices conditions questionnaire...
Background Obesity among persons living with HIV (PLWH) has increased and weight gain after antiretroviral therapy (ART) can lead to metabolic disorders impact survival. Our objective was analyze changes in näive patients 48 weeks of ART. Methods Observational, retrospective, multicentered cohort study comprising naïve-patients who started tenofovir alafenamide/emtricitabine/elvitegravir/cobicistat (TAF/FTC/EVG/c) or abacavir/lamivudine/dolutegravir (ABC/3TC/DTG), no change treatment for...
Although RTS as HIV Diagnosis was considered cost effectiveness [1], overall budget may be unaffordable for some countries. We explore Incremental per NDHI associated with different TS.From a health care perspective, using direct costs and Euros currency, we calculated of (all patients were tested), TTS (Universal risk practices clinical conditions-RP&CC - only positive CPTS (Only physicians tested). DRIVE (Spanish acronym infection Rapid Diagnosis) study Practice outcomes. Population...
Objectives: The aims of this study were to describe patients' experiences after single-tablet regimen (STR) desimplification and its impact on self-reported treatment adherence quality life. Methods: We performed a survey among all patients from the multicenter cohort Spanish HIV/AIDS Network who had desimplified STRs dolutegravir/abacavir/lamivudine (DGT/ABC/3TC) or rilpivirine/tenofovir disoproxil fumarate/emtricitabine their separate components (DTG + generic ABC/3TC RPV TDF/FTC) between...
We assessed the opinions of physicians caring for people with HIV (PWH) from multicentre Spanish CoRIS cohort regarding assessment health-related quality life (HRQoL). designed an online self-administered questionnaire comprising 27 structured questions across four domains: (i) sociodemographic and clinical data; (ii) usefulness measuring HRQoL; (iii) information, training resource needed; (iv) whether how HRQoL should be measured. Physicians completed between April June 2023. Of 131...
To investigate the role of previous antibiotic therapy in risk recurrence after a Clostridioides difficile infection (CDI) treated with vancomycin.Multicentre observational study. Patients CDI episode achieving clinical cure oral vancomycin and followed up 8 weeks were included. Previous exposure to 90 days was collected. Multivariate analysis predictors adjusted by propensity score (PS) being previously each non-CDI performed.Two hundred forty-one patients included; 216 (90%) had received...
Early diagnosis and treatment of incident cases hepatitis C virus (HCV) infection is fundamental to eliminate HCV in HIV-positive patients. From January 2016 December 2019, we attended 40 episodes acute (AHC) 35 subjects (9 reinfections) who were coinfected with HIV. The patients treated direct-acting antiviral agents (DAAs) seven hospitals Andalusia, Spain. All men have sex (MSM), mean age was 42.9 (±8.3) years median time HIV 46.6 months (IQR: 20.4–67.2). received antiretroviral therapy...
Purpose of study Irregular FUP/ADH were associated with virologic failure [ 1 ] leading to an increase in mortality 2 ]. SEAD was a multidimensional intervention project, designed from the patient's perspective, specifically attend patients poor FUP/ ADH HIV/AIDS outpatient clinic. Methods From Jan 2006 May 2010, offered inclusion, all evaluated by nurse or psychologist (adherence collaborators) who assessed reasons and barriers precluding correct FUP/ADH. For each identified problem,...
Introduction No controlled clinical trials had studied the role of maraviroc (MRV) in fully suppressed patients [ 1 ]. Materials and Methods MRV‐cohort is an observational, retrospective, multicentric (27 sites) large cohort study starting MRV practice under different circumstances, with at least 48 weeks follow‐up. For present analysis we selected all those HIV‐RNA<50 copies/mL. Demographics, baseline CD4 cell count, past history antiretroviral treatment (ART), tropism, reasons for use,...