A5018152227- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- HIV Research and Treatment
- Mycobacterium research and diagnosis
- Antibiotics Pharmacokinetics and Efficacy
- Vector-borne infectious diseases
- Parvovirus B19 Infection Studies
- Bacterial Identification and Susceptibility Testing
- Viral Infections and Vectors
- Fungal Infections and Studies
- Diphtheria, Corynebacterium, and Tetanus
- Immunodeficiency and Autoimmune Disorders
- Long-Term Effects of COVID-19
- Antifungal resistance and susceptibility
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Mosquito-borne diseases and control
- Nosocomial Infections in ICU
- Pharmacological Effects and Toxicity Studies
Tulane University
2012-2024
Louisiana State Department of Health and Hospitals
2023
Massachusetts General Hospital
2023
Scynexis (United States)
2019
University Medical Center New Orleans
1991-2012
University of Mississippi Medical Center
2009
Jackson Memorial Hospital
2009
Louisiana State University Health Sciences Center New Orleans
1995
Louisiana State University
1995
Background. Invasive candidiasis is the third most common bloodstream infection in intensive care unit (ICU) and associated with morbidity mortality. Prophylaxis preemptive therapy are attractive strategies for this setting. Methods. We conducted a multicenter, randomized, double-blind, placebo-controlled trial of caspofungin as antifungal prophylaxis 222 adults who were ICU at least 3 days, ventilated, received antibiotics, had central line, 1 additional risk factor (parenteral nutrition,...
To evaluate the safety and efficacy of two dosing regimens oral ibrexafungerp (formerly SCY-078), a novel orally bioavailable β-glucan synthase inhibitor, in subjects with invasive candidiasis versus standard care (SOC) to identify dose achieve target exposure (15.4 μM·h) >80% intended population.In multinational, open-label study, patients documented were randomized receive step-down therapy one three treatment arms: or SOC following initial echinocandin therapy. Plasma samples collected by...
ObjectivesTo determine: (1) the pharmacokinetics and safety of an investigational aminoquinoline active against multidrug–resistant malaria parasites (AQ-13), including its effects on QT interval, (2) whether it has pharmacokinetic profiles similar to chloroquine (CQ) in humans.DesignPhase I double-blind, randomized controlled trials compare AQ-13 CQ healthy volunteers. Randomizations were performed at each step after completion previous dose.SettingTulane–Louisiana State University–Charity...
In April 2008, the Infectious Diseases Society of America (IDSA) entered into an agreement with Connecticut Attorney General Richard Blumenthal to voluntarily undertake a special review its 2006 Lyme disease guidelines. This ended General's investigation process by which guidelines were developed. The IDSA agreed convene independent panel conduct one-time Review Panel members, vetted ombudsman for potential conflicts interest, reviewed entirety guidelines, particular attention...
People with HIV (PWH) have a high burden of coronary plaques; however, the comparison to people without known (PwoH) needs clarification.
ABSTRACT This study evaluated the tolerance and potential pharmacokinetic interactions between clarithromycin (500 mg every 12 h) rifabutin (300 daily) in clinically stable human immunodeficiency virus-infected volunteers with CD4 counts of <200 cells/mm 3 . Thirty-four subjects were randomized equally to either regimen A or B. On days 1 14, assigned received B rifabutin, then both groups drugs on 15 42. Of 14 who started combination therapy, subject each group prematurely discontinued...
BackgroundChloroquine was used for malaria treatment until resistant Plasmodium falciparum identified. Because 4-aminoquinolines with modified side chains, such as AQ-13, are active against parasites, we compared AQ-13 artemether plus lumefantrine of uncomplicated P malaria.MethodsWe did a randomised, non-inferiority trial. We screened men (≥18 years) in Missira (northeast Mali) and Bamako (capital eligibility (≥2000 asexual parasites per μL blood). Eligible participants were randomly...
<h3>Background:</h3> We conducted a trial to compare treatment with zidovudine or didanosine in patients advanced human immunodeficiency virus type 1 (HIV-1) infection who had received little no previous therapy zidovudine. <h3>Methods:</h3> Six hundred seventeen acquired syndrome (AIDS), AIDS-related complex (CD4 cell count, ≤0.30× 10<sup>9</sup>/L [300/μL]), asymptomatic HIV ≤0.20× 10<sup>9</sup>/L) zidovudine, 500 mg/d of didanosine, 750 randomized, double-blind allocation, cross-over...
Low CD4 recovery among HIV-positive individuals who achieve virologic suppression is common but has not been studied initiating treatment at counts of >500 cells/mm.United States, Africa, Asia, Europe and Israel, Australia, Latin America.Among participants randomized to immediate antiretroviral therapy (ART) in the Strategic Timing AntiRetroviral Therapy trial, low was defined as a increase <50 cells/mm from baseline after 8 months despite viral load ≤200 copies/mL. Risk factors for were...
ABSTRACT This multicenter study evaluated the tolerance and potential pharmacokinetic interactions between azithromycin rifabutin in volunteers with or without human immunodeficiency virus infection. Daily dosing combination of was poorly tolerated, primarily because gastrointestinal symptoms neutropenia. No significant were found these drugs.
High-level penicillin resistance has been associated with treatment failure in patients Streptococcus pneumoniae infections. To identify a subgroup of at low risk for high-level penicillin-nonsusceptible S. bacteremia, cross-sectional study 303 was performed. For the total population, observed 98 (32%) patients; seen 33 (11%). A predictive model created by using 3 baseline variables that were independently resistance: previous beta -lactam antibiotic use, stay area (defined as day care...
Abstract On November 7, 2018, the National Rifle Association (NRA) issued a tweet advising “self-important anti-gun doctors to stay in their lane.” The has galvanized physicians share experiences with gun violence through grassroots #ThisISOurLane campaign. Infectious diseases are regularly called upon manage complications such as infected wounds and osteomyelitis gunshot victims. Yet, Diseases specialty been poorly represented national dialogue on violence. Over 80 medical societies have...
Abstract Background Among people with HIV (PWH), COVID-19 is common and potentially severe. We leveraged REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) assess the effects of statin therapy for cardiovascular disease prevention on outcomes (incidence serious cases) among a global cohort PWH. Methods data collection was implemented April 2020 capture events from January 2020. defined by positive test result or clinical diagnosis according International Conference Harmonisation...
Four patients with adult-onset, disseminated mycobacterial infection had 5' UTR mutations in IKBKG without clear physical stigmata of NEMO deficiency. These caused decreased levels protein and Toll-like receptor driven cytokine production. Three died from disease. may be missed by whole exome sequencing.
Abstract Background Patterns of antiretroviral therapy (ART) use and immunologic correlates vary globally, contemporary trends are not well described. Methods The REPRIEVE trial (Randomized Trial to Prevent Vascular Events in HIV) enrolled persons with human immunodeficiency virus (HIV) who were aged 40–75 years, receiving ART, had low-to-moderate cardiovascular disease risk. ART was summarized within Global Burden Disease (GBD) super-regions, adjusted linear logistic regression analyses...