A5055471574- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Use and Resistance
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotics Pharmacokinetics and Efficacy
- HIV Research and Treatment
- Sepsis Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Streptococcal Infections and Treatments
- Escherichia coli research studies
- Pneumonia and Respiratory Infections
- Pancreatitis Pathology and Treatment
- Parasite Biology and Host Interactions
- Autoimmune and Inflammatory Disorders Research
- Bacillus and Francisella bacterial research
- Diverse Scientific Research Studies
Hospital de Poniente
2011-2024
Hospital Regional Universitario de Málaga
2020-2024
Instituto de Investigación Biomédica de Málaga
2020-2023
Biomedical Research and Innovation Institute of Cadiz
2022
Hospital Universitario Reina Sofía
2007-2010
Infections caused by carbapenemase-producing Enterobacterales (CPE) are not well represented in pivotal trials with ceftazidime/avibactam. The best strategy for the treatment of these infections is unknown.We conducted a multicentre retrospective observational study patients who received ≥48 h ceftazidime/avibactam or available therapy (BAT) documented CPE infections. primary outcome was 30 day crude mortality. Secondary outcomes were 21 clinical response and microbiological response. A...
Abstract To date, former research about the impact of HIV infection on mpox poor outcomes is still limited and controversial. Therefore, aim this study was to assess clinical course mpox, in a large population patients from Spain. Nationwide case‐series study. Patients 18 Spanish hospitals, with PCR‐confirmed April 27, 2022 June 30, 2023 were included The main outcome development long or complicated (LC) defined as: (i) duration ≥ 28 days, or; (ii) disseminated disease, or: (iii) emergence...
BackgroundEscherichia coli is the most frequent cause of bloodstream infections (BSIs). About one-third patients with BSIs due to E develop sepsis or shock. The objective this study characterise microbiological features blood isolates causing septic shock provide exploratory information for future diagnostic, preventive, therapeutic interventions.MethodsE from a multicentre cross-sectional older than 14 years presenting (according Third International Consensus Definitions Sepsis and Septic...
The objective of this study was to investigate the efficacy and safety early treatment with sarilumab, added standard care (SOC), in hospitalized adults COVID-19. Methods included phase II, open-label, randomized, controlled clinical trial patients COVID-19 pneumonia interleukin (IL)-6 levels ≥ 40 pg/mL and/or d-dimer > 1,500 ng/mL.
Background Unexpected cases of severe liver disease in HIV-infected patients have been reported and an association with didanosine (ddI) has suggested. Transient elastography (TE) might detect harbouring such a condition. Our objective was to search for the presence abnormal stiffness (LS) cohort without HBV or HCV coinfection assess related factors. Methods A cross-sectional prospective study conducted. LS assessed by TE 258 no evidence acute hepatotoxicity other origins disease. values...
Background and Aims Several studies have reported that a significant number of HIV patients not co-infected with HCV/HBV develop liver damage uncertain origin (LDUO). The objective our study was to evaluate the incidence risk factors for development LDUO in infected HCV/HBV. Methods Prospective longitudinal included HIV-infected free previous viral hepatitis B or C co-infections. Patients were followed up at 6-monthly intervals. Liver stiffness measured each visit. Abnormal (ALS) defined as...
Abstract Background Catheter-related bloodstream infections (CRBSIs) increase morbidity and mortality, prolong hospitalization generate considerable medical costs. Recent guidelines for CRBSI recommend empirical therapy against Gram-positive bacteria (GPB) restrict coverage Gram-negative (GNB) only to specific circumstances. Objectives To investigate predictors of GNB aetiology in assess the outcome patients with CRBSI. Methods Patients were selected from PROBAC cohort, a prospective,...
<h3>Background:</h3> The factors that influence liver fibrosis progression in patients co-infected with human immunodeficiency virus/hepatitis C virus (HIV/HCV) are not completely understood. It is known if insulin resistance (IR), a condition promotes HCV mono-infected individuals, one of these factors. <h3>Objective:</h3> To evaluate the association between IR and stiffness (LS). <h3>Design:</h3> Multicentre cross-sectional study. <h3>Patients:</h3> 330 HIV/HCV. <h3>Methods:</h3> LS was...
To evaluate the changes in liver stiffness measurement (LSM) patients infected by hepatitis C virus (HCV) under pegylated interferon (Peg-IFN) plus ribavirin therapy.One hundred and forty-three HCV-infected patients, of whom 97 (68%) were also carrying HIV, who started treatment with Peg-IFN/ribavirin included this prospective cohort study. The outcome variable study was change LSM between baseline scheduled date for evaluating sustained virological response (SVR).The median (Q1-Q3) values...
To compare the frequency of grade 3 or 4 transaminase elevations (TEs) in HIV/hepatitis C virus (HCV) co-infected patients who started a three-antiretroviral drug regimen including efavirenz ritonavir-boosted protease inhibitor (PI/r) and influence pre-existing significant hepatic fibrosis cirrhosis. All pre-treated treatment-naive HIV/HCV an antiretroviral two nucleos(t)ide reverse transcriptase inhibitors along with PI/r seven Spanish centres from January 2007 to December 2009 were...
Abstract Several studies have reported the persistence of HCV RNA in liver and/or peripheral blood mononuclear cells (PBMCs) spite undetectable viremia patients who achieved sustained virological response (SVR). This event, defined as occult infection, remains controversial and low titers persistent virus may be underestimated because it has not yet been analyzed by a highly sensitive test such droplet digital PCR (ddPCR). method provides an alternate ultra-sensitive detection technique for...
Abstract Objectives to undertake a multidisciplinary follow-up at 12 weeks after an acute episode of COVID-19 assess the functional status, persistence symptoms and immunoserological situation. Methods this prospective, observational, single-centre study included outpatients reviewed infection with SARS-CoV-2. The clinical evaluation data about epidemiological variables. patients were classified as symptomatic or asymptomatic depending on otherwise symptoms. All underwent full blood test...
To evaluate the effect of interleukin 28B (IL-28B) genotype on hepatitis C virus (HCV) viral kinetics in first 4 weeks from start treatment with pegylated interferon plus ribavirin (PEG-IFN/RBV) HIV/HCV co-infected patients.HIV/HCV patients naive to PEG-IFN/RBV were enrolled a prospective study. HCV RNA plasma loads measured at baseline and 1, 2 after commencement treatment. Patients grouped by (genotype 1/4 versus 3) IL-28B (CC non-CC). Differences load reduction evaluated between baseline,...
Objective To assess the current frequency of ART-associated grade 3–4 transaminase elevations (TE) and 4 total bilirubin (TBE) in HIV-infected patients with chronic hepatitis B and/or C, who start a new regimen ART. Patients Methods A 192 pre-treated or treatment-naive HIV infected HBV HCV-coinfection started ART eight Southern Spanish centers from July/2011-December/2013, were followed for 12 months this prospective study. Results Forty-one (21.4%) subjects had been naïve to ART, median...
Abstract Background Klebsiella aerogenes has been reclassified from Enterobacter to genus due its phenotypic and genotypic similarities with pneumoniae . It is unclear if clinical outcomes are also more similar. This study aims assess of bloodstreams infections (BSI) caused by K. aerogenes, cloacae , through secondary data analysis, nested in PRO-BAC cohort study. Methods Hospitalized patients between October 2016 March 2017 monomicrobial BSI or E. were included. Primary outcome was a...
To evaluate the effect of low-density lipoprotein receptor (LDLr) and IL28B genotypes on hepatitis C virus (HCV) viral kinetics in first 4 weeks treatment with pegylated-interferon (PEG-IFN)/ribavirin (RBV) HIV patients co-infected HCV genotype 1.HIV 1 naïve to PEG-IFN/RBV were enrolled a prospective study. RNA loads measured at baseline 1, 2 after start therapy. Differences load decline evaluated for (CC versus non-CC) LDLr between 4. Additionally, CC (CC/CC CC/non-CC) was...
The aim of this study was to evaluate whether the assessment hepatitis C virus (HCV) RNA serum at 12 weeks after end treatment (W12) as informative 24 (W24) for determining sustained virological response (SVR) in HIV/HCV co-infected patients who received a combination pegylated interferon (PEG-INF) plus ribavirin (PEG-INF/RBV) and had treatment. Treatment-naive were included prospective if they completed full course therapy with PEG-INF/RBV, an undetectable HCV complied W12 W24 schedule RNA....
The aim of this study was to determine the predictive capacity response at treatment week (TW) 4 for achievement sustained virological 12 weeks after scheduled end therapy date (SVR12) against hepatitis C virus (HCV) genotype 3 (GT3) infection with all-oral direct-acting antiviral (DAA) -based regimens.From a prospective multicohort study, HCV GT3-infected patients who completed course currently recommended DAA-based 33 Spanish hospitals and had reached SVR12 evaluation time-point were...