A5100784358- graph theory and CDMA systems
- Finite Group Theory Research
- Coding theory and cryptography
- Religious and Theological Studies
- Protein Structure and Dynamics
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Photoreceptor and optogenetics research
- Cuban History and Society
- Monoclonal and Polyclonal Antibodies Research
- Nonlinear Dynamics and Pattern Formation
- Theology and Canon Law Studies
- Gene Regulatory Network Analysis
- Algebraic structures and combinatorial models
- Plant and Biological Electrophysiology Studies
- Slime Mold and Myxomycetes Research
- Advanced Topics in Algebra
- Advanced Algebra and Logic
- Bacterial biofilms and quorum sensing
- Immunodeficiency and Autoimmune Disorders
- Epigenetics and DNA Methylation
- Spanish Literature and Culture Studies
- Graph theory and applications
- Hepatitis C virus research
- Chaos control and synchronization
University of the Basque Country
2016-2025
Basque Center for Applied Mathematics
2019-2023
Universidad Nacional Autónoma de México
2014-2023
Harvey Mudd College
2020
BioCruces Health research Institute
2014-2019
Stony Brook School
2016
TCM-Intigrated Cancer Center of Southern Medical University
2016
NOVO Cellular Medicine Institute
2016
Cellular Therapeutics (United Kingdom)
2016
University of Trinidad and Tobago
2016
Biochemical energy is the fundamental element that maintains both adequate turnover of biomolecular structures and functional metabolic viability unicellular organisms. The levels ATP, ADP AMP reflect roughly energetic status cell, a precise ratio relating them was proposed by Atkinson as adenylate charge (AEC). Under growth-phase conditions, cells maintain AEC within narrow physiological values, despite extremely large fluctuations in adenine nucleotides concentration. Intensive...
Associative memory is the main type of learning by which complex organisms endowed with evolved nervous systems respond efficiently to certain environmental stimuli. It has been found in different multicellular species, from cephalopods humans, but never individual cells. Here we describe a motility pattern consistent associative conditioned behavior microorganism Amoeba proteus. We use controlled direct-current electric field as stimulus, and specific chemotactic peptide unconditioned...
Biological membranes are composed of lipid bilayers that often asymmetric with regards to the composition and/or aqueous solvent they separate. Studying asymmetry both experimentally and computationally is challenging. Molecular dynamics simulations difficult due finite system sizes time scales accessible simulations. Due very slow flip-flop rate for phospholipids, one must first choose how many lipids on each side bilayer, but resulting bilayer may be unstable (or metastable) differing...
p53 and Notch-1 play important roles in breast cancer biology. inhibits activity cervical cells. Conversely, Notch T-cells but stimulates it human keratinocytes. co-activator MAML1 binds functions as a co-activator. We studied the regulation of signaling by MCF-7 cells normal mammary epithelial (HMEC). Results show that overexpression or activation endogenous with Nutlin-3 Notch-dependent transcriptional target expression dose-dependent manner. This effect could be partially rescued...
The capacity to learn new efficient systemic behavior is a fundamental issue of contemporary biology. We have recently observed, in preliminary analysis, the emergence conditioned some individual amoebae cells. In these experiments, cells were able acquire migratory patterns and remember them for long periods their cellular cycle, forgetting later on. Here, following similar conceptual framework Pavlov's we exhaustively studied migration trajectories more than 2000 belonging three different...
Background Over many years, it has been assumed that enzymes work either in an isolated way, or organized small catalytic groups. Several studies performed using “metabolic networks models” are helping to understand the degree of functional complexity characterizes enzymatic dynamic systems. In a previous work, we used “dissipative metabolic networks” (DMNs) show can present self-organized global structure, which several sets always active state, whereas rest molecular exhibit dynamics...
Chemotaxis (i.e., directed migration) of hepatic stellate cells to areas inflammation is a requisite event in the liver's response injury. Previous studies signaling pathways that regulate cell migration suggest key role for focal adhesions, but exact function these protein complexes motility remains unclear. Focal adhesions attach its substrate and therefore must be regulated highly coordinated manner during migration. To test hypothesis adhesion turnover an essential early chemotaxis...
The first part of this paper is a survey about strongly regular graphs and digraphs admitting semiregular cyclic group automorphisms. In the second part, some new types such digraphs, called uniform almost uniform, are studied. By using partial sum families, form parameters determined directed derived from these families with previously unknown obtained.
The aim of this study was to determine the predictive capacity response at treatment week (TW) 4 for achievement sustained virological 12 weeks after scheduled end therapy date (SVR12) against hepatitis C virus (HCV) genotype 3 (GT3) infection with all-oral direct-acting antiviral (DAA) -based regimens.From a prospective multicohort study, HCV GT3-infected patients who completed course currently recommended DAA-based 33 Spanish hospitals and had reached SVR12 evaluation time-point were...
We introduce a new class of graphs, called quasi <TEX>$m$</TEX>-Cayley having good symmetry properties, in the sense that they admit group automorphisms G fixes vertex graph and acts semiregularly on other vertices. determine when these graphs are strongly regular, this leads us to define algebro-combinatorial structure, quasi-partial difference family, or QPDF for short. give several infinite families sporadic examples QPDFs. also study properties QPDFs determine, under conditions, form...
Abstract Coronavirus disease 2019 (COVID-19) is the greatest threat to global health at present time, and considerable public private effort being devoted fighting this recently emerged disease. Despite undoubted advances in development of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative agent COVID-19, uncertainty remains about their future efficacy duration immunity induced. It therefore prudent continue designing testing pathogen. In article we...
A method to estimate the persistent behavior from a chaotic time series is proposed. Persistency means that here each value depends some extent on previous values and not only recent ones. The data were analyzed by of Hurst's rescaled range method, i.e., R/S analysis (which was introduced Mandelbrot Wallis). relation Hurst exponent self-affine self-simialr fractal dimension discussed.
We generalize the notion of λ-superstrings, presented in a previous paper, to weighted λ-superstrings. This generalization entails an important improvement applications vaccine designs, as it allows epitopes be by their immunogenicities. Motivated these potential constructing short λ-superstrings design, we approach this problem two ways. First, formalize combinatorial optimization (in fact, polynomially equivalent problems) and develop integer programming (IP) formulation for solving...
Chloride is the most abundant permeable anion in cell, and numerous studies last two decades highlight great importance broad physiological role of chloride currents mediated transport. They participate a multiplicity key processes, as for instance, regulation electrical excitability, apoptosis, cell cycle, epithelial secretion neuronal excitability. In addition, dysfunction Cl- channels involved variety human diseases such epilepsy, osteoporosis different cancer types. Historically, have...