A5086030926- Photoreceptor and optogenetics research
- Slime Mold and Myxomycetes Research
- Plant and Biological Electrophysiology Studies
- vaccines and immunoinformatics approaches
- Hippo pathway signaling and YAP/TAZ
- Polysaccharides and Plant Cell Walls
- Bacterial biofilms and quorum sensing
- Monoclonal and Polyclonal Antibodies Research
- Photosynthetic Processes and Mechanisms
- DNA and Nucleic Acid Chemistry
- Cellular transport and secretion
- Gene Regulatory Network Analysis
- Planarian Biology and Electrostimulation
- Cellular Mechanics and Interactions
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
University of the Basque Country
2019-2025
Basque Center for Applied Mathematics
2023
Ben-Gurion University of the Negev
2020-2021
Associative memory is the main type of learning by which complex organisms endowed with evolved nervous systems respond efficiently to certain environmental stimuli. It has been found in different multicellular species, from cephalopods humans, but never individual cells. Here we describe a motility pattern consistent associative conditioned behavior microorganism Amoeba proteus. We use controlled direct-current electric field as stimulus, and specific chemotactic peptide unconditioned...
Abstract Directional motility is an essential property of cells. Despite its enormous relevance in many fundamental physiological and pathological processes, how cells control their locomotion movements remains unresolved question. Here, we have addressed the systemic processes driving directed Specifically, performed exhaustive study analyzing trajectories 700 individual belonging to three different species (Amoeba proteus, Metamoeba leningradensis, Amoeba borokensis) four scenarios:...
The capacity to learn new efficient systemic behavior is a fundamental issue of contemporary biology. We have recently observed, in preliminary analysis, the emergence conditioned some individual amoebae cells. In these experiments, cells were able acquire migratory patterns and remember them for long periods their cellular cycle, forgetting later on. Here, following similar conceptual framework Pavlov's we exhaustively studied migration trajectories more than 2000 belonging three different...
Summary Modern health care needs preventive vaccines and therapeutic treatments with stability against pathogen mutations to cope current future viral infections. At the beginning of COVID-19 pandemic, our analytic predictive tool identified a set eight short SARS-CoV-2 S-spike protein epitopes that had potential persistently avoid mutation. Here combination genetic, Systems Biology structure analyses confirm mutations. Remarkably, this research spans whole period during which 93.9% peptides...
Abstract Directional motility is an essential property of cells. Despite its enormous relevance in many fundamental physiological and pathological processes, how cells control their locomotion movements remains unresolved question. Here we have addressed the systemic processes driving directed Specifically, performed exhaustive study analyzing trajectories 700 individual belonging to three different species ( Amoeba proteus , Metamoeba leningradensis borokensis ) four scenarios: absence...
Abstract Directional locomotion is a fundamental characteristic of many cells with great relevance in essential physiological and human pathological processes. For decades, research efforts have focused on studying specific individual processes their corresponding biomolecular components involved cellular movements. However, the notion that migratory displacements are functionally integrated regulated at systemic level has never been recognized. Recently, we shown movements correspond to an...
In the last few years, importance of neoantigens in development personalized antitumor vaccines has increased remarkably. order to study whether bioinformatic tools are effective detecting that generate an immune response, DNA samples from patients with cutaneous melanoma different stages were obtained, resulting a total 6048 potential gathered. Thereafter, immunological responses generated by some those ex vivo tested, using vaccine designed new optimization approach and encapsulated...
Abstract The capacity to learn new systemic behaviour is a fundamental issue understand the adaptive mechanisms involved in cellular evolution. We have recently observed, preliminary analysis, emergence of conditioned individual amoebae cells. In these experiments, cells were able acquire migratory conduct and remember it for long periods their cycle, forgetting later on. Here, following similar conceptual framework Pavlov’s we exhaustively studied migration trajectories more than 2000...