A5082196048- Photoreceptor and optogenetics research
- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Assisted Reproductive Technology and Twin Pregnancy
- Plant and Biological Electrophysiology Studies
- Immunotherapy and Immune Responses
- Slime Mold and Myxomycetes Research
- Reproductive Health and Technologies
- Protein Structure and Dynamics
- Reproductive Biology and Fertility
- Ectopic Pregnancy Diagnosis and Management
- Ovarian function and disorders
- SARS-CoV-2 and COVID-19 Research
- Receptor Mechanisms and Signaling
- Preterm Birth and Chorioamnionitis
- Polysaccharides and Plant Cell Walls
- Immunodeficiency and Autoimmune Disorders
- Endometriosis Research and Treatment
- Hippo pathway signaling and YAP/TAZ
- Bacterial biofilms and quorum sensing
- Cellular Mechanics and Interactions
- Planarian Biology and Electrostimulation
- Sperm and Testicular Function
- Breast Cancer Treatment Studies
- Radio, Podcasts, and Digital Media
University of the Basque Country
2014-2025
BioCruces Health research Institute
2014-2024
Bioef - Fundación Vasca de Innovación e Investigación Sanitarias
2021-2024
Hospital de Cruces
2020
Biochemical energy is the fundamental element that maintains both adequate turnover of biomolecular structures and functional metabolic viability unicellular organisms. The levels ATP, ADP AMP reflect roughly energetic status cell, a precise ratio relating them was proposed by Atkinson as adenylate charge (AEC). Under growth-phase conditions, cells maintain AEC within narrow physiological values, despite extremely large fluctuations in adenine nucleotides concentration. Intensive...
Associative memory is the main type of learning by which complex organisms endowed with evolved nervous systems respond efficiently to certain environmental stimuli. It has been found in different multicellular species, from cephalopods humans, but never individual cells. Here we describe a motility pattern consistent associative conditioned behavior microorganism Amoeba proteus. We use controlled direct-current electric field as stimulus, and specific chemotactic peptide unconditioned...
Abstract Directional motility is an essential property of cells. Despite its enormous relevance in many fundamental physiological and pathological processes, how cells control their locomotion movements remains unresolved question. Here, we have addressed the systemic processes driving directed Specifically, performed exhaustive study analyzing trajectories 700 individual belonging to three different species (Amoeba proteus, Metamoeba leningradensis, Amoeba borokensis) four scenarios:...
The capacity to learn new efficient systemic behavior is a fundamental issue of contemporary biology. We have recently observed, in preliminary analysis, the emergence conditioned some individual amoebae cells. In these experiments, cells were able acquire migratory patterns and remember them for long periods their cellular cycle, forgetting later on. Here, following similar conceptual framework Pavlov's we exhaustively studied migration trajectories more than 2000 belonging three different...
To evaluate the influence on sperm parameters and in vitro fertilization (IVF) outcomes of administration 400 mg/day vitamin E for 3 months to men from infertile couples who are undergoing IVF.Double-blind, placebo-controlled, randomized study.Human reproduction unit a university hospital.A total 101 couples, 50 group 51 placebo group, IVF, among whom 64.4% cases had an abnormal spermiogram according World Health Organization (WHO) criteria.Vitamin (α-tocopherol), mg daily by mouth months,...
Abstract Purpose To ascertain whether physical activity (PA) is associated with better sperm quality in donors. Methods A prospective case–control study was designed an IVF center setting. total of 207 donation candidates from a relatively small geographical area were included the no intervention. Donor subjected to conventional analysis according WHO criteria. Moreover, they answered standardized questionnaire regarding their last week PA (IPAQ), expressed metabolic equivalents...
Abstract For a wide range of cells, from bacteria to mammals, locomotion movements are crucial systemic behavior for cellular life. Despite its importance in plethora fundamental physiological processes and human pathologies, how unicellular organisms efficiently regulate their system is an unresolved question. Here, understand the dynamic characteristics quantitatively study role nucleus migration Amoeba proteus we have analyzed movement trajectories enucleated non-enucleated amoebas on...
Abstract Coronavirus disease 2019 (COVID-19) is the greatest threat to global health at present time, and considerable public private effort being devoted fighting this recently emerged disease. Despite undoubted advances in development of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative agent COVID-19, uncertainty remains about their future efficacy duration immunity induced. It therefore prudent continue designing testing pathogen. In article we...
We generalize the notion of λ-superstrings, presented in a previous paper, to weighted λ-superstrings. This generalization entails an important improvement applications vaccine designs, as it allows epitopes be by their immunogenicities. Motivated these potential constructing short λ-superstrings design, we approach this problem two ways. First, formalize combinatorial optimization (in fact, polynomially equivalent problems) and develop integer programming (IP) formulation for solving...
Chloride is the most abundant permeable anion in cell, and numerous studies last two decades highlight great importance broad physiological role of chloride currents mediated transport. They participate a multiplicity key processes, as for instance, regulation electrical excitability, apoptosis, cell cycle, epithelial secretion neuronal excitability. In addition, dysfunction Cl- channels involved variety human diseases such epilepsy, osteoporosis different cancer types. Historically, have...
This paper presents a new procedure for vaccine design against highly variable viruses such as Hepatitis C. The uses an optimization algorithm to vaccines that maximize the coverage of epitopes across different virus variants. Weighted based on success ratio immunological assays are used prioritize selection design. was successfully applied DC loaded with two HCV peptides, STG and DYP, which were shown be safe, immunogenic, able induce significant levels anti-viral cytokines,...
Abstract How motile, free unicellular organisms maximize the rate at which they encounter resources and develop optimal search strategies remains largely unknown. In fact, cell foraging is a very complex activity in integrate diversity of external cues efficient systemic movements to localize nourishment. These are critical when cells face conditions scarce or don’t possess information on where food located. Here, order determine whether nuclear directly involved migration, we placed single,...
Summary Modern health care needs preventive vaccines and therapeutic treatments with stability against pathogen mutations to cope current future viral infections. At the beginning of COVID-19 pandemic, our analytic predictive tool identified a set eight short SARS-CoV-2 S-spike protein epitopes that had potential persistently avoid mutation. Here combination genetic, Systems Biology structure analyses confirm mutations. Remarkably, this research spans whole period during which 93.9% peptides...
In this study, 529 variables extracted from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of 922 breast cancer patients have been evaluated, focusing on distinguishing between recurrent and non-recurrent cases, as well those with without metastasis. Special emphasis is placed the differences among invasive subtypes (Luminal A, Luminal B, HER2 positive, TNBC). The accurate identification subtype crucial it impacts both treatment prognosis. analysis based dataset Saha et al.,...
Abstract Directional motility is an essential property of cells. Despite its enormous relevance in many fundamental physiological and pathological processes, how cells control their locomotion movements remains unresolved question. Here we have addressed the systemic processes driving directed Specifically, performed exhaustive study analyzing trajectories 700 individual belonging to three different species ( Amoeba proteus , Metamoeba leningradensis borokensis ) four scenarios: absence...
Abstract Directional locomotion is a fundamental characteristic of many cells with great relevance in essential physiological and human pathological processes. For decades, research efforts have focused on studying specific individual processes their corresponding biomolecular components involved cellular movements. However, the notion that migratory displacements are functionally integrated regulated at systemic level has never been recognized. Recently, we shown movements correspond to an...