A5083250797- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Health Systems, Economic Evaluations, Quality of Life
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Sarcoidosis and Beryllium Toxicity Research
- Urticaria and Related Conditions
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Cell Adhesion Molecules Research
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Hematological disorders and diagnostics
- Vitamin D Research Studies
- Clinical Reasoning and Diagnostic Skills
- Innovations in Medical Education
- Vitamin C and Antioxidants Research
- COVID-19 Clinical Research Studies
- Cinema History and Criticism
- Chronic Lymphocytic Leukemia Research
- Infectious Diseases and Tuberculosis
- Platelet Disorders and Treatments
- Inflammasome and immune disorders
- Health and Medical Education
- Nosocomial Infections in ICU
- Pharmaceutical studies and practices
Universitat Autònoma de Barcelona
2004-2021
Corporació Sanitària Parc Taulí
2001-2021
Institute of Research and Innovation Parc Tauli
2020-2021
Deleted Institution
1998-2019
Universitat de Barcelona
1999-2001
Bellvitge University Hospital
2001
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
1999
University Hospital Ulm
1996
Hospital Clínic de Barcelona
1996
Hospital Virgen del Valle
1987
<h3>Background</h3> Much clinical research of relevance to elderly patients examines individuals who are younger than those have the disease in question. A good example is heart failure. Therefore, we investigated extent exclusion older ongoing trials regarding <h3>Methods</h3> In context Increasing PaRticipation ElDerly Clinical Trials (PREDICT) study, data from failure were extracted World Health Organization Registry Platform on December 1, 2008. Main outcome measures proportion excluding...
Objective To identify clinical and biochemical parameters that have good predictive value for identifying giant cell (temporal) arteritis (GCA) patients who are at high or low risk of developing cranial ischemic events. Methods In this multicenter study, records 3 university hospitals in Barcelona were reviewed retrospectively. Two hundred consecutive with biopsy-proven GCA studied. Results Thirty-two developed irreversible complications. The duration symptoms before diagnosis was similar...
The aim of this study was to describe the clinical characteristics ANCA-associated vasculitides (AAV) at presentation, in a wide cohort Spanish patients, and analyze impact vasculitis type, ANCA specificity, prognostic factors, treatments administered diagnosis, outcome. A total 450 patients diagnosed between January 1990 2014 20 Hospitals from Spain were included. Altogether, 40.9% had granulomatosis with polyangiitis (GPA), 37.1% microscopic (MPA), 22% eosinophilic (EGPA). mean age...
Abstract Introduction The purpose of this observational study was to analyze the rates, characteristics and associated risk factors severe infections in patients with systemic autoimmune diseases (SAD) who were treated off-label biological agents daily practice. Methods BIOGEAS registry is an ongoing Spanish prospective cohort investigating long-term safety efficacy use adult severe, refractory SAD. Severe defined according previous studies as those that required intravenous treatment or led...
Objectives Rituximab (RTX) is a biological treatment used off-label in patients with systemic lupus erythematosus (SLE). This survey aimed to investigate the use of RTX Europe and compare characteristics receiving those conventional therapy. Methods Data on SLE were taken from International Registry for Biologics retrospective registry complemented data treated For nationwide estimates SLE, investigators asked provide through case report forms (CRFs). Countries which no submitted CRFs,...
Objective To compare the accuracy of Birmingham Vasculitis Activity Score ( BVAS ), version 3, and Five Factor FFS 1996 2009, to assess survival in antineutrophil cytoplasmic antibody–associated vasculitis AAV ). Methods A total 550 patients with (41.1% granulomatosis polyangiitis, 37.3% microscopic 21.6% eosinophilic polyangiitis), diagnosed between 1990 2016, were analyzed. Receiver operating characteristic ROC ) curves multivariable Cox analysis used relationships outcome different...
Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in experimental models acute lung injury. In this study, we aimed to analyze associations between calcitriol supplementation and risk SARS-CoV2 infection or COVID-19 mortality. Individuals ≥18 years old living Catalonia supplemented from April 2019 February 2020 were compared propensity score matched controls. Outcome variables infection, severe Associations outcome analyzed using multivariable Cox...
Background There is an urgent need to reduce mortality of COVID-19. We examined if corticosteroids and tocilizumab risk for death in patients with severe pneumonia caused by SARS-CoV-2.
<h3>OBJECTIVE</h3> To evaluate whether changes in concentrations of circulating adhesion molecules are related to disease activity patients with giant cell arteritis (GCA). <h3>METHODS</h3> A sandwich ELISA was used measure soluble intercellular molecule-1 (sICAM-1), sICAM-3, vascular (sVCAM-1), E-selectin (sE-selectin), and L-selectin (sL-selectin) serum plasma samples from GCA. cross sectional study performed on 64 GCA at different stages 35 age sex matched healthy donors. Thirteen these...
Two patients with Hodgkin's disease developed a condition that has been termed “reactive perforating collagenosis.” In both cases, pruritus was severe and seemed to be responsible for the vigorous rubbing scratching caused skin lesions. one patient, lesions disappeared upon remission of disease. Perforating collagenosis described in children as hereditary disease, also adults diabetes on hemodialysis. On basis changes seen our two we suggest is simply consequence intense scratching.
We analyse the safety and effectiveness of self-outpatient parenteral antimicrobial therapy (s-OPAT) in older patients.We prospectively evaluated all adults admitted to our home hospitalization unit (HHU) for s-OPAT period 2008-12 whom bacteria responsible infection were identified. divided patients into three age groups: <65, 65-79 ≥80 years. was administered by or their caregivers using elastomeric infusion devices. Effectiveness assessed analysing readmissions hospital inadequate control...
OBJECTIVE: To determine fluctuation in circulating von Willebrand factor (vWF) the outcome of patients with temporal arteritis. METHODS: Plasma vWF antigen concentrations were measured 65 biopsy proven arteritis at different disease activity stages, 12 isolated polymyalgia rheumatica, and 16 controls. Fourteen underwent serial determinations during course their disease. RESULTS: significantly raised (mean 220 [arbitrary units], range 96 to 720) rheumatica 196, 103 266) compared healthy...
Treatment with calcitriol, the hormonal form of vitamin D, has shown beneficial effects in ex-perimental models acute lung injury. In this study we aimed to analyze associations be-tween calcitriol supplementation and risk SARS-CoV2 infection or COVID-19 mortality. Individuals &ge;18 years old living Catalonia supplemented from April 2019 February 2020 were compared propensity score matched controls. Outcome variables infection, severe Associations between outcome analyzed using...
Long-term observation of patients with ANCA-associated vasculitis (AAV) allows the identification different longitudinal patterns ANCA levels during follow-up. This study aimed to characterize these and determine their prognostic significance. All determinations performed in two university hospitals a 2-year period were retrospectively reviewed. Patients included analysis if they had high titers anti-myeloperoxidase (anti-MPO) or anti-proteinase 3 (anti-PR3) antibodies at least once, ≥ 5...
The objective was to evaluate whether changes in circulating soluble adhesion molecule levels reflect disease activity patients with systemic polyarteritis nodosa (PAN). A sandwich ELISA used measure (s) intercellular 1 (sICAM-1), vascular cell (sVCAM-1), E-selectin, L-selectin and P-selectin sera plasma from 22 active PAN, 13 of these taken serially during follow-up, healthy controls. At the time diagnosis, sICAM-1, sVCAM-1 sE-selectin (488.5 +/- 201.3, 1176.5 514.1 60.6 27 ng/ml,...
We hereby describe the satisfactory evolution of rituximab treatment in two patients with Wegener's granulomatosis (WG). Rituximab was indicated for refractoriness to standard one case and life-threatening myelotoxicity due alkylating agents other. A brief review previous experience use WG is presented.
Tumor necrosis factor alpha (TNF) is a key cytokine in the defense against many intracellular pathogens, including Rickettsia conorii, causative agent of Mediterranean spotted fever (MSF). The levels two soluble TNF receptors (sTNFR-p55 and sTNFR-p75), extracellular domains cell surface for TNF, were elevated acute-stage plasma samples from 20 patients with serologically confirmed MSF. median values 3.1 7.8 ng/ml sTNFR-p55 sTNFR-p75, respectively. sTNFR correlated significantly...