A5014935322- Bacterial Identification and Susceptibility Testing
- Trypanosoma species research and implications
- Streptococcal Infections and Treatments
- Research on Leishmaniasis Studies
- Gut microbiota and health
- Oral microbiology and periodontitis research
- Clostridium difficile and Clostridium perfringens research
- DNA and Nucleic Acid Chemistry
- Infective Endocarditis Diagnosis and Management
- Calcium signaling and nucleotide metabolism
- Biochemical and Molecular Research
- Advanced biosensing and bioanalysis techniques
- Bone health and osteoporosis research
- Diphtheria, Corynebacterium, and Tetanus
- Glycosylation and Glycoproteins Research
- Iron Metabolism and Disorders
- Soil Carbon and Nitrogen Dynamics
- Microbial Community Ecology and Physiology
- RNA Interference and Gene Delivery
- Synthesis and Biological Evaluation
- Biocrusts and Microbial Ecology
- Bone health and treatments
- Endodontics and Root Canal Treatments
- Dental Radiography and Imaging
- Bone Metabolism and Diseases
Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research
2015-2025
Instituto de Investigación Biosanitaria de Granada
2015-2025
Hospital Universitario Virgen de las Nieves
2022-2025
Universidad de Granada
2014-2017
Instituto de Parasitología y Biomedicina "López - Neyra"
1994-2015
Complejo Hospitalario Universitario de Granada
2015
Consejo Superior de Investigaciones Científicas
2007-2011
Complexo Hospitalario Universitario A Coruña
2010
Institute of Pathology and Genetics
2002-2004
Université Libre de Bruxelles
2003
Diabetes mellitus is a risk factor for osteoporotic fractures. Sclerostin an inhibitor of bone formation. However, there are no data about sclerostin levels in type 2 diabetes (T2DM).The aims were to evaluate serum T2DM patients and analyze its relationship with metabolism.This was cross-sectional study. We compared the group (n = 74) control 50), we analyzed calciotropic hormones, turnover markers, mineral density (BMD), morphometric vertebral fractures.Sclerostin significantly higher than...
OBJECTIVE Wnt/β-catenin signaling is related to the pathogenesis of several diseases. Sclerostin an inhibitor signaling. However, there are few data regarding sclerostin levels and vascular disease. Our aim was examine relationship between serum atherosclerotic disease (AD) in type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS We performed a cross-sectional study including 78 T2DM patients (45.3% females, mean age 59 ± 5.7 years; 54.7% males, 57.4 6.7 years). RESULTS Serum...
Scriptaid is a chemical compound with anti-tumoural effects due to its role as histone deacetylase inhibitor. Despite sharing part of the structure other ligands G-quadruplexes (G4s), interaction G4s has not been explored before. We synthesized and screened cytotoxic activity in cellular models colorectal cancer (CRC). extensively evaluated biological by cell cycle, immunofluorescence, qRT-PCR Western blot experiments. To identify G4 targets Scriptaid, we conducted panel binding assays....
African trypanosomiasis is a deadly neglected disease caused by the extracellular parasite Trypanosoma brucei. Current therapies are characterized high drug toxicity and increasing resistance mainly associated with loss-of-function mutations in transporters involved import. The introduction of new antiparasitic drugs into therapeutic use slow expensive process. In contrast, specific targeting existing could represent more rapid cost-effective approach for treatment, impacting through reduced...
Current research on the influence of environmental and physicochemical factors in shaping soil bacterial structure has seldom been approached from a pedological perspective. We studied communities eight soils selected along pedogenic gradient at local scale Mediterranean calcareous mountain (Sierra de María, SE Spain). The results showed that relative abundance Acidobacteria, Canditate division WPS-1, Armatimonadetes decreased whereas Actinobacteria, Bacteroidetes, Proteobacteria increased...
Abstract Next generation sequencing methods are widely used in evaluating the structure and functioning of microbial communities, especially those centered on 16S rRNA subunit. Since Illumina Miseq, most platform, does not allow full gene, this study aims to evaluate whether choice different target regions might affect outcome microbiome studies regarding soil saliva samples. V1V3, V3V4, V4V5 V6V8 domains were studied, finding that while some showed differences detection certain bacterial...
The activation of inflammasomes is thought to induce the inflammatory process around dental implants. No information available on correlation between microbiota and in clinical samples from patients suffering peri-implantitis. For this cross-sectional study, 30 biofilm were obtained 19 undergoing surgical treatment for peri-implantitis because presence bleeding probing, probing depth higher than 6 mm, radiographic bone loss 3 mm. Then, soft tissue implant also collected. relative abundance...
Abstract Aim The aim of this study was to analyse and compare the microbiome present in root canals periapical lesions teeth with post‐treatment infections, identify presence keystone taxa both habitats using next‐generation sequencing analysis. Methodology Apices patients apical periodontitis were surgically extracted. Specimens cryo‐pulverized, bacterial DNA extracted, V3–V4 hypervariable regions 16S rRNA gene sequenced Illumina Miseq platform. Bioinformatic analysis carried out Mothur...
Iron deficiency is the top leading cause of anaemia, whose treatment has been shown to deteriorate gut health. However, a comprehensive analysis intestinal barrier and microbiome during IDA have not performed date. This study aims delve further into these two aspects, which will mean step forward minimising negative impact iron supplements on was experimentally induced in an animal model. Shotgun sequencing used analyse colonic region, while studied through histological analyses, mRNA...
The adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification different liposome prototypes had been developed in our group for targeted delivery drugs Plasmodium-infected red blood cells (pRBCs). These models include: (i) immunoliposome-mediated release lipid-based antimalarials; (ii)...
To assess and compare the microbiome of paired root apices periapical lesions from cases with failed endodontic treatment to associate bacterial metabolic pathways in both sites asymptomatic apical periodontitis (AAP) symptomatic (SAP), using next-generation sequencing (NGS).Matched patients canal treatments were surgically extracted. Specimens cryopulverized, DNA was extracted V3-V4 hypervariable regions 16 S rRNA gene amplified sequenced Illumina Miseq platform. Diversity community...
Natural phenolic compounds have gained momentum for the prevention and treatment of cancer, but their antitumoral mechanism action is not yet well understood. In present study, we screened potential several in a cellular model colorectal cancer (CRC). We selected gallic acid (GA) as candidate terms potency selectivity extensively evaluated its biological activity. report on role GA ligand DNA G-quadruplexes (G4s), explaining effects, including transcriptional inhibition ribosomal CMYC genes....