A5000349727- Allergic Rhinitis and Sensitization
- Plant Reproductive Biology
- Food Allergy and Anaphylaxis Research
- Bone health and treatments
- Bone health and osteoporosis research
- Botanical Research and Chemistry
- Plant and soil sciences
- Plant and fungal interactions
- Botanical Research and Applications
- Mycorrhizal Fungi and Plant Interactions
- Parathyroid Disorders and Treatments
- Proteins in Food Systems
- Garlic and Onion Studies
- Edible Oils Quality and Analysis
- Genetic and Environmental Crop Studies
- Genetic Syndromes and Imprinting
- Diatoms and Algae Research
- Adipokines, Inflammation, and Metabolic Diseases
- Bacteriophages and microbial interactions
- Circadian rhythm and melatonin
- Horticultural and Viticultural Research
- Cocoa and Sweet Potato Agronomy
- Digestive system and related health
- Wnt/β-catenin signaling in development and cancer
- Cardiac Fibrosis and Remodeling
Instituto de Investigación Biosanitaria de Granada
2014-2023
Instituto de Salud Carlos III
2015-2022
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2017-2020
Universidad de Los Andes
2000-2018
University of the Andes
2007-2018
Endocrinology Research Center
2018
Biomedical Research Institute
2018
University of Quindío
2013
Estación Experimental del Zaidín
2012-2013
Consejo Superior de Investigaciones Científicas
2005-2013
Diabetes mellitus is a risk factor for osteoporotic fractures. Sclerostin an inhibitor of bone formation. However, there are no data about sclerostin levels in type 2 diabetes (T2DM).The aims were to evaluate serum T2DM patients and analyze its relationship with metabolism.This was cross-sectional study. We compared the group (n = 74) control 50), we analyzed calciotropic hormones, turnover markers, mineral density (BMD), morphometric vertebral fractures.Sclerostin significantly higher than...
Laying hens were inoculated orally, intracloacally (IC), or intravenously (IV) with Salmonella enteritidis phage type 8 isolates from a human (E700-87) eggs (Y-8P2), the ovary of hen (27A). Oral IV inoculation 2 x 10(8) to 4 colony-forming units (CFU) E700-87 caused depression, anorexia, reduced egg production, diarrhea, and some mortality. Lower doses resulted in milder clinical signs. S. was cultured shells few but not contents. Fecal shedding persisted for up 6 weeks birds. Isolate Y-8P2...
OBJECTIVE Wnt/β-catenin signaling is related to the pathogenesis of several diseases. Sclerostin an inhibitor signaling. However, there are few data regarding sclerostin levels and vascular disease. Our aim was examine relationship between serum atherosclerotic disease (AD) in type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS We performed a cross-sectional study including 78 T2DM patients (45.3% females, mean age 59 ± 5.7 years; 54.7% males, 57.4 6.7 years). RESULTS Serum...
Cardiovascular diseases are a health problem throughout the world, especially in people with diabetes. The identification of cardiovascular disease biomarkers can improve risk stratification. Sclerostin is modulator Wnt/β-catenin signalling pathway different tissues, and it has recently been linked to vascular biology. current study aimed evaluate relationship between circulating sclerostin levels non-cardiovascular mortality individuals without type 2 We followed up cohort 130 participants...
Profilin, a multigene family involved in actin dynamics, is multiple partners-interacting protein, as regard of the presence at least three binding domains encompassing actin, phosphoinositide lipids, and poly-L-proline interacting patches. In addition, pollen profilins are important allergens several species like Olea europaea L. (Ole e 2), Betula pendula (Bet v Phleum pratense (Phl p 12), Zea mays (Zea m 12) Corylus avellana (Cor 2). spite biological clinical importance these molecules,...
Objectives Dickkopf-1 (DKK1) is a potent inhibitor of Wnt signalling, which exerts anabolic effects on bone and also takes part in the regulation vascular cells. Our aims were to evaluate serum DKK1 type 2 diabetes (T2DM) patients analyze its relationships with cardiovascular disease (CVD). We evaluated relationship between metabolism. Design conducted cross-sectional study we measured (ELISA, Biomedica) 126 subjects: 72 T2DM 54 non-diabetic subjects. analysed clinical CVD, preclinical CVD...
(1) Background: Inflammation molecular cues and insulin resistance development are some of the main contributors for advance pathogenesis inflammatory-related diseases; (2) Methods: We isolated purified γ-conglutin protein from narrow-leafed lupin (NLL or blue lupin) mature seeds using affinity-chromatography to evaluate its anti-inflammatory activities at level both, a bacterial lipopolysaccharide (LPS)-induced inflammation an pancreatic cell models; (3) Results: NLL achieved plethora...
Type 2 diabetes mellitus patients are at significant risk of cardiovascular disease, however, the pathophysiology these complications is complex and incompletely known in this population. The aim study was to compare serum proteome with type presenting or not disease non-diabetic subjects find essential proteins related complications. This cross-sectional compares by a combination protein depletion 2D-DIGE (2-dimension Difference Gel Electrophoresis) methodology. differentially expressed...
Summary Pollen allergens offer a dual perspective of study: some them are considered key proteins for pollen physiology, but they also able to trigger allergy symptoms in susceptible humans after coming contact with their tissues. Profilin (Ole e 2 allergen) has been characterized, extent, as one the major from Olea europaea L. pollen, highly allergenic species Mediterranean countries. In order obtain clues regarding biological role this protein, we have analyzed both its cellular...
There are wide interindividual differences in the risk of developing alcoholic cirrhosis. Transforming growth factor beta(1) (TGF-beta(1)) is main cytokine involved liver fibrogenesis. The TGF-beta(1) gene polymorphic at several sites and these polymorphisms probably related to rate synthesis. Our aim has been analyse influence predisposition advanced disease (ALD) ethanol abusers.TGF-beta(1) single nucleotide positions -509 (C or T), +869 T, codon 10), +915 G, 25) were examined 165...
Seventy‐six Salmonella enteritidis, three virchow and one braedenrup strains were screened for enterotoxigenicity by using the Chinese hamster ovary (CHO), Y1 adrenal, Vero HeLa cell tests. All gave positive reactions enterotoxin production, except one, relative sensitivity to toxin exhibited different lines was evaluated. An enterotoxic activity has been identified in sonicated extracts of Salm. enteritidis: This purified on Agarose A‐5m (Bio‐Rad) Superose 12 HR 10/30 column. The eluted...