A5031516359- Bone health and osteoporosis research
- Alkaline Phosphatase Research Studies
- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Heterotopic Ossification and Related Conditions
- Bone health and treatments
- Vitamin K Research Studies
- Biochemical and Molecular Research
- Bone Metabolism and Diseases
- Pharmacogenetics and Drug Metabolism
- Lipoproteins and Cardiovascular Health
- Drug-Induced Hepatotoxicity and Protection
- Metabolism, Diabetes, and Cancer
- Bone and Joint Diseases
- Cardiac Fibrosis and Remodeling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Alzheimer's disease research and treatments
- Bone and Dental Protein Studies
- Clusterin in disease pathology
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Selenium in Biological Systems
- Protein Kinase Regulation and GTPase Signaling
Instituto de Investigación Biosanitaria de Granada
2018-2024
Universidad de Granada
2022-2024
Instituto Andaluz de Ciencias de la Tierra
2022-2024
Instituto de Salud Carlos III
2023
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2023
Cardiovascular diseases are a health problem throughout the world, especially in people with diabetes. The identification of cardiovascular disease biomarkers can improve risk stratification. Sclerostin is modulator Wnt/β-catenin signalling pathway different tissues, and it has recently been linked to vascular biology. current study aimed evaluate relationship between circulating sclerostin levels non-cardiovascular mortality individuals without type 2 We followed up cohort 130 participants...
Abstract Hypophosphatasia (HPP) is a genetic disease caused by one or several mutations in ALPL gene encoding the tissue-nonspecific alkaline phosphatase affecting mineralization process. Due to its low prevalence and lack of recognition, this metabolic disorder generally confused with other more frequent bone disorders. An assessment serum total (ALP) levels was performed 78,590 subjects. Pyridoxal-5′-phosphate (PLP) concentrations were determined sequenced patients potentially affected...
Abstract Undercarboxylated osteocalcin (ucOC) could be a biomarker of glucose disturbances and cardiovascular risk. Our study aimed to determine the association between serum levels ucOC risk in metabolic syndrome (MetS) patients analyse its potential role as estimator type 2 diabetes (T2D) this population. This cross-sectional included 235 with MetS, 53.2% women, aged 55–75 years. Circulating were measured by ELISA. Cardiovascular was determined Z-score diagnostic criteria for MetS (CV-ZS)....
Since the prevalence of hypophosphatasia (HPP), a rare genetic disease, seems to be underestimated in clinical practice, this study, new diagnostic algorithm identify missed cases HPP was developed and implemented.
Sclerostin is an inhibitor of the Wnt/b-catenin pathway, which regulates bone formation, and can be expressed in vascular smooth muscle cells (VSMCs). Type 2 diabetes (T2D) associated with increased risk cardiovascular disease (CVD) serum tissue expression sclerostin. However, whether role sclerostin detrimental or protective development CVD unknown. Therefore, our aims are to determine level T2D patients with/without controls, both at tissue, analyze VSMCs under calcified environments.
Hypophosphatasia (HPP) is an inborn metabolic error caused by mutations in the ALPL gene encoding tissue non-specific alkaline phosphatase (TNSALP) and leading to decreased (ALP) activity. Although main characteristic of this disease bone involvement, it presents a great genetic clinical variability, which makes systemic disease. Patients were recruited based on biochemical assessments. Diagnosis was made measuring serum ALP pyridoxal 5-phosphate levels finally Sanger sequencing from...
Non-alcoholic fatty liver disease (NAFLD) seems to have some molecular links with atherosclerosis (ATH); however, the pathways which connect both pathologies remain unexplored date. The identification of common factors is great interest explore therapeutic strategies improve outcomes for those affected patients. Differentially expressed genes (DEGs) NAFLD and ATH were extracted from GSE89632 GSE100927 datasets, up- downregulated DEGs identified. Subsequently, a protein-protein interaction...
Hepatotoxicity, a common adverse drug effect, has been extensively studied in adult patients. However, it is equally important to investigate this condition pediatric patients develop personalized treatment strategies for children. This study aimed identify plasma biomarkers that characterize hepatotoxicity through an observational case-control study. Metabolomic analysis was conducted on 55 with xenobiotic liver toxicity and 88 healthy controls. The results revealed clear differences...
Osteoglycin (OGN) could be a biomarker of mild kidney function impairment in type 2 diabetes (T2D). Our study aimed to determine the association between serum OGN and impaired risk T2D patients analyze its potential role as an estimator disturbances this population. This cross-sectional included 147 (65 ± 8 years, 58.5% males), 75 healthy controls (63 10 36% males). Circulating levels were determined by ELISA. Linear regression modeling was performed variables influencing circulating OGN,...
Lifestyle changes are causing an exponential increase in the prevalence of obesity and metabolic syndrome (MetS) worldwide. The most frequent complications these development diabetes (T2D) cardiovascular disease (CVD). Accurate tools needed to classify risk (CVR) MetS population. In recent years, numerous biomarkers bone metabolism have been associated with CVR. aim this study was determine levels undercarboxylated osteocalcin (ucOC) a cohort patients analyse its association parameters CVR...
The identification of common targets in Alzheimer's disease (AD) and cardiovascular (CVD) recent years makes the study CVD/AD axis a research topic great interest. Besides aging, other links between CVD AD have been described, suggesting existence molecular mechanisms. Our aimed to identify axis. For this purpose, genomic data from calcified healthy femoral artery samples were used differentially expressed genes (DEGs), which generate protein-protein interaction network, where module related...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Idiosyncratic drug-induced liver injury (DILI) is a complex multifactorial disease in which the toxic potential of drug, together with genetic and acquired factors deficiencies adaptive processes, limit extent damage, may determine susceptibility make individuals unique their development hepatotoxicity. In our study, we sequenced exomes 43 pediatric patients diagnosed DILI to identify important gene variations associated this pathology. The result showed presence two NAT2 gene: c.590G>A...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Hypophosphatasia (HPP) a rare disease caused by mutations in the ALPL gene encoding for tissue-nonspecific alkaline phosphatase protein (TNSALP), has been identified as potentially under-diagnosed condition worldwide which may have higher prevalence than currently established. This is largely due to overlapping of its symptomatology with that other more frequent pathologies. Although HPP usually associated deficient bone mineralization, high genetic variability results clinical...
Osteoglycin, a fundamental proteoglycan within the vascular extracellular matrix, is expressed in smooth muscle cells (VSMCs). Type 2 diabetes (T2D) associated with cardiovascular disease (CVD) but role of osteoglycin development CVD controversial to date. Therefore, our aims are determine and compare level T2D patients with/without versus control subjects both at serum tissue analyze vitro VSMCs under calcified conditions. For this, levels were determined by enzyme-linked immunosorbent...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)