A5021551603- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Cardiac Arrest and Resuscitation
- Immune Cell Function and Interaction
- Chemotherapy-induced organ toxicity mitigation
- Emergency and Acute Care Studies
- Respiratory Support and Mechanisms
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Hepatitis C virus research
- Drug Transport and Resistance Mechanisms
- Neuroendocrine Tumor Research Advances
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer therapeutics and mechanisms
- Infective Endocarditis Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Craniofacial Disorders and Treatments
- Metabolism and Genetic Disorders
- Diverse Education Studies and Reforms
- Hepatitis B Virus Studies
- Cleft Lip and Palate Research
- Complementary and Alternative Medicine Studies
- Systemic Lupus Erythematosus Research
- Pregnancy and preeclampsia studies
- Cerebrospinal fluid and hydrocephalus
Hospital Universitario Virgen de las Nieves
2013-2024
Instituto de Investigación Biosanitaria de Granada
2011-2024
Universidad de Granada
2015-2024
Hospital Materno-Infantil
2019
Complejo Hospitalario Universitario de Granada
2015-2017
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2013
Stratford University
2005
University of Udine
2005
Brisbane School of Theology
2005
The vertical transmission of hepatitis C virus (HCV-VT) is a major route HCV infection in children, but the risk factors remain incompletely understood. This study analyzed role interleukin 28B (IL28B) HCV-VT and spontaneous clearance among infected infants. Between 1991 2009, 145 mothers were recruited for this study: 100 HCV-RNA+ve / human immunodeficiency negative (HIV-ve), with 128 33 HCV-RNA-ve/HCV antibody+ve, 43 children. infants tested HCV-RNA at birth regular intervals until age 6...
This study analyses the evolution of liver disease in women with chronic hepatitis C during third trimester pregnancy and post-partum period, as a natural model immune modulation reconstitution. Of 122 mothers recruited to this study, 89 were HCV-RNA+ve/HIV-ve 33 HCV-RNA-ve/HIV-ve/HCVantibody+ve all tested pregnancy, at delivery post-delivery. The HCV-RNA+ve categorized either Type-A (66%), an increase ALT levels period (>40 U/L; P<0.001) or Type-B (34%), no variation values. also presented...
ABSTRACT Objectives: Idiosyncratic drug‐induced liver injury is a multifactorial complex disease, in which the toxic potential of drug, together with genetic and acquired factors deficiencies adaptive processes, limit extent damage, can determine susceptibility, make individuals unique their development hepatotoxicity. The aim present study to analyse (human leukocyte antigen [HLA], cytokine polymorphisms, killer cell immunoglobulin‐like receptor [KIR] genotype) children who experience an...
Hepatotoxicity, a common adverse drug effect, has been extensively studied in adult patients. However, it is equally important to investigate this condition pediatric patients develop personalized treatment strategies for children. This study aimed identify plasma biomarkers that characterize hepatotoxicity through an observational case-control study. Metabolomic analysis was conducted on 55 with xenobiotic liver toxicity and 88 healthy controls. The results revealed clear differences...
The aim was to test the hypothesis that preoperative infusion of levosimendan would decrease patients' cardiac biomarker profiles during immediate postoperative stage (troponin I and B-type natriuretic peptide levels) more efficiently than placebo after cardiopulmonary bypass. In a randomised, placebo-controlled, double-blinded study, 30 paediatric patients were scheduled for congenital heart disease surgery. 15 (50%) received prophylactic from 12 h before bypass 24 Troponin levels higher in...
La unidad de cuidados intensivos pediátricos (UCIP) es una física asistencial hospitalaria independiente especialmente diseñada para el tratamiento pacientes quienes debido su gravedad o condiciones potencialmente letales requieren observación y asistencia médica intensiva integral continua por un equipo médico que haya obtenido competencia especial en medicina pediátrica. aplicación oportuna terapia a los críticos reduce la mortalidad, tiempo estancia costes asistenciales. Con objetivos...
Drug-induced liver injury due to chemotherapy is an important cause of morbidity in cancer patients, although its clinical manifestations are poorly understood. The objective the present study was determine characteristics (forms presentation, severity, and type injury) hepatotoxicity children treated for cancer. A total 22 oncological patients were included study, after ruling out other causes increased transaminases (infectious, metabolic, autoimmune, or hereditary), according CIOMS...
Idiosyncratic drug-induced liver injury (DILI) is a complex multifactorial disease in which the toxic potential of drug, together with genetic and acquired factors deficiencies adaptive processes, limit extent damage, may determine susceptibility make individuals unique their development hepatotoxicity. In our study, we sequenced exomes 43 pediatric patients diagnosed DILI to identify important gene variations associated this pathology. The result showed presence two NAT2 gene: c.590G>A...
A paediatric intensive care unit (PICU) is a separate physical facility or specifically designed for the treatment of patients who, because severity illness other life-threatening conditions, require comprehensive and continuous by medical team with special skills in medicine. Timely personal intervention reduces mortality, length stay, decreases cost care. With aim defending right child to receive highest attainable standard health facilities rehabilitation, as well ensuring quality safety...
La lesión hepática inducida por fármacos debida a quimioterapia es una causa importante de morbilidad en enfermos oncológicos aunque sus manifestaciones clínicas son poco conocidas. El objetivo del presente estudio fue determinar las características (formas presentación, gravedad y tipo lesión) la hepatotoxicidad niños tratados cáncer. Se incluyó el un total 22 oncológico los que, tras descartar otras causas aumento transaminasas (infecciosa, metabólica, autoinmune o hereditaria), se...
The consumption of herbal products is mainly due to the perception that being "natural" can only be beneficial and without risk health. However properties thereof are poorly studied proven. Four episodes presented hepatotoxicity from products, by three children. We analyse epidemiological clinical characteristics these stress importance proper anamnesis for accurate diagnosis. El consumo de productos herboristería es debido principalmente a la percepción que al ser “naturales”, solo pueden...
La distracción osteogénica mandibular es una relativamente nueva técnica quirúrgica de alargamiento para aliviar la obstrucción vía aérea en pacientes con hipoplasia mandibular. Ha revolucionado el manejo defectos campo cirugía craneofacial, y procedimiento se ha convertido ampliamente aceptado hospitales todo mundo. Describir evolución tasa complicaciones postoperatorio inmediato Hospital Materno-Infantil Granada, hospital referencia andaluz dicha técnica. Estudio observacional descriptivo...
Research findings in pharmacogenetics have shown that the response to chemotherapy is largely determined by genetic polymorphisms.Thus, children with same type of tumour given treatment may present different responses, terms not only effectiveness but also toxicity.We analyse recent studies polymorphisms associated use and development hepatotoxicity, highlighting importance generalised methotrexate.
The molecular interactions between killer-cell immunoglobulin-like receptors (KIRs) and their related HLA class I ligands play a central role in regulating the responses of natural killer (NK) cells. Our study aim was to determine played by KIR genes genetic predisposition for development hepatotoxicity children treated with chemotherapy an oncological process.The group composed 22 cancer, being at Unit Pediatric Oncology Maternity Hospital Virgen de las Nieves (Granada, Spain) presenting...
Natural killer (NK) cells play an important role in defense against tumor cells. The development and function of NK is governed by a dynamic balance between inhibition activation cell surface receptors, including KIR receptors.A case-control study carried out that compares group 46 children diagnosed with malignant diseases, the control made up 82 healthy children. KIRs genes, haplotypes ligands were determined compared groups.There are no differences or gene groups. However, when KIRS...
BACKGROUND: The molecular interactions between killer-cell immunoglobulin-like receptors (KIRs) and their related HLA class I ligands play a central role in regulating the responses of natural killer (NK) cells. Our study aim was to determine played by KIR genes genetic predisposition for development hepatotoxicity children treated with chemotherapy an oncological process.METHODS: group composed 22 cancer, being at Unit Pediatric Oncology Maternity Hospital Virgen de las Nieves (Granada,...
La endocarditis infecciosa (EI) es una patología que conlleva elevada morbimortalidad y representa un problema creciente de salud pública. El tratamiento quirúrgico necesario en más la mitad los casos, su principal finalidad eliminar totalmente el tejido infectado reconstruir anatomía cardiaca normal, incluyendo reparación o sustitución la/s válvula/s afectada/s. presente estudio se centra describir procedimiento apropiado para cirugía mitral casos EI, atendiendo a literatura amplia...
Arachnoid cysts are central nervous system lesions that infrequently occur in childhood. They can be mobile and produce partial or complete obstruction the Cerebrospinal Fluid (CSF) circulation. usually present at birth asymptomatic, although sometimes symptoms appear adolescence adulthood due to growth acceleration [1,2].
Natural killer (NK) cells play an important role in defense against tumor cells. The development and function of NK is governed by a dynamic balance between inhibition activation cell surface receptors, including KIR receptors.