A5015195908- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Coronary Artery Anomalies
- Ion channel regulation and function
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Receptor Mechanisms and Signaling
- Mitochondrial Function and Pathology
- Protein Tyrosine Phosphatases
- Metabolism and Genetic Disorders
- Muscle Physiology and Disorders
- Medical research and treatments
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Italian Fascism and Post-war Society
- Galectins and Cancer Biology
- Cardiovascular Issues in Pregnancy
- Cardiovascular Conditions and Treatments
- Mechanical Circulatory Support Devices
- Infectious Encephalopathies and Encephalitis
Hospital Universitario Virgen de las Nieves
2013-2023
Instituto de Investigación Biosanitaria de Granada
2020-2023
Hospital Materno-Infantil
2021
Complejo Hospitalario Universitario de Granada
2016-2017
Pediatrics and Genetics
2012
In a family with inappropriate sinus tachycardia (IST), we identified mutation (p.V240M) of the hyperpolarization-activated cyclic nucleotide–gated type 4 (HCN4) channel, which contributes to pacemaker current (I f ) in human sinoatrial node cells. Here, clinically study fifteen members and functionally analyze p.V240M variant. Macroscopic HCN4 single-channel currents were recorded using patch-clamp cells expressing native (WT) and/or channels. All carriers exhibited IST that was accompanied...
Background: CaM (calmodulin) mutations are associated with congenital arrhythmia susceptibility (calmodulinopathy) and most often de novo. In this report, we sought to broaden the genotype-phenotype spectrum of calmodulinopathies 2 novel calmodulin investigate mosaicism in affected families. Methods: were identified 4 independent cases by DNA sequencing. Biochemical electrophysiological studies performed determine functional consequences each mutation. Results: Genetic variants ( CALM3...
Takayasu arteritis (TA) in the child remains a therapeutic challenge because corticosteroids and conventional immunosuppressive agents are not always safe or efficacious. The complex formed by interleukin-6 (IL-6) soluble IL-6 receptor appears to play pivotal role pathogenesis of TA. We describe favorable response anti-IL-6 antibody tocilizumab (TCZ) with aggressive refractory TA including an assessment proinflammatory cytokine profile. A 3-year-old girl consisting thickening aortic arch...
Background Calmodulin 1, 2 and 3 (CALM) mutations have been found to cause cardiac arrest in children at a very early age. The underlying aetiology described is long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT) idiopathic fibrillation (IVF). Little phenotypical data about CALM2 available. Objectives aim of this paper describe the clinical manifestations Asn98Ser mutation two unrelated southern Spain with apparently unexplained arrest/death. Methods Two...
The aim was to test the hypothesis that preoperative infusion of levosimendan would decrease patients' cardiac biomarker profiles during immediate postoperative stage (troponin I and B-type natriuretic peptide levels) more efficiently than placebo after cardiopulmonary bypass. In a randomised, placebo-controlled, double-blinded study, 30 paediatric patients were scheduled for congenital heart disease surgery. 15 (50%) received prophylactic from 12 h before bypass 24 Troponin levels higher in...
Abstract The use of conventional implantable cardioverter-defibrillators (ICDs) in children presents important technical challenges. We present the surgical technique necessary to adapt subcutaneous ICD (S-ICD) implantation designed for adults, children, including patients weighing less than 20 kg. implant procedure implies a two-incision and interfascial serratus anterior–latissimus dorsi dissection accommodate device. S-ICD was successfully performed three 19, 28, 24 kg, respectively, two...
El impacto negativo del sobrepeso y la obesidad es potencialmente mayor en niños con cardiopatía congénita (CC). objetivo estudio determinar proporción de intervenidos CC valorar existencia hipertensión arterial sistólica como posible complicación precoz. Estudio descriptivo retrospectivo, incluyendo pacientes controles sanos entre 6 17 años seguimiento una consulta Cardiología Pediátrica. Se calcularon los percentiles índice masa corporal según las tablas OMS se analizaron variables...
The negative impact of overweight and obesity is potentially greater in children affected by a congenital heart disease (CHD). aim this study to calculate the proportion who underwent an intervention for CHD, investigate systolic arterial hypertension as possible early cardiovascular complication. A retrospective was conducted on patients aged 6–17 years treated healthy control subjects, followed-up Paediatric Cardiology Clinic. Body mass index percentiles were calculated according criteria...
We present a case of sarcomeric hypertrophy cardiomyopathy diagnosed in child who had degree regression during adolescence, with no left ventricular dysfunction and increase the diameters. (Level Difficulty: Intermediate.)