A5062119204- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Calcium signaling and nucleotide metabolism
- Cardiomyopathy and Myosin Studies
- Research on Leishmaniasis Studies
- Pluripotent Stem Cells Research
- Trypanosoma species research and implications
- Cancer Cells and Metastasis
- CRISPR and Genetic Engineering
- Spinal Dysraphism and Malformations
- 3D Printing in Biomedical Research
- Spinal Cord Injury Research
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Ion Channels and Receptors
- Adenosine and Purinergic Signaling
- Virus-based gene therapy research
- Lipid Membrane Structure and Behavior
- Traumatic Brain Injury Research
- Extracellular vesicles in disease
- Neuroscience and Neural Engineering
- Congenital heart defects research
Max Delbrück Center
2023
Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research
2013-2016
Instituto de Parasitología y Biomedicina "López - Neyra"
2008-2013
Instituto de Investigación Biosanitaria de Granada
2013
Consejo Superior de Investigaciones Científicas
2008-2012
Mexican Social Security Institute
2010
Centro Medico Nacional Siglo XXI
2010
Hospital de Especialidades
2010
Administration of in vitro expanded mesenchymal stromal cells (MSCs) represents a promising therapy for regenerative medicine and autoimmunity. Both mouse human MSCs ameliorate autoimmune disease syn-, allo- xenogeneic settings. However, MSC preparations are heterogeneous which impairs their therapeutic efficacy endorses variability between experiments. This heterogeneity has also been main hurdle translating experimental data from models to patients. The objective the present manuscript...
Abstract The complex neuromuscular network that controls body movements is the target of severe diseases result in paralysis and death. Here, we report development a robust efficient self-organizing junction (soNMJ) model from human pluripotent stem cells can be maintained long-term simple adherent conditions. timely application specific patterning signals instructs simultaneous differentiation position-specific brachial spinal neurons, skeletal muscles, terminal Schwann cells. High-content...
Mesenchymal stromal cells (MSCs) represent a promising tool for therapy in regenerative medicine, transplantation, and autoimmune disease due to their trophic immunomodulatory activities. However, we are still far from understanding the mechanisms of action MSCs these processes. Transforming growth factor (TGF)-β1 is pleiotropic cytokine involved MSC migration, differentiation, immunomodulation. Recently, glycoprotein A repetitions predominant (GARP) was shown bind latency-associated peptide...
Regulation of RNA polymerase II transcription initiation is apparently absent in trypanosomes. Instead, these eukaryotes control gene expression mainly at the post-transcriptional level. exerted through action numerous RNA-binding proteins that modulate mRNA processing, turnover, translation and localization. In this work we show protein DRBD3 resides cytoplasm, but localizes to nucleus upon oxidative challenge stress granules under starvation conditions. associates with other form a...
Multiple sclerosis (MS) is a severe debilitating disorder characterized by progressive demyelination and axonal damage of the central nervous system (CNS). Current therapies for MS inhibit immune response demonstrate reasonable benefits if applied during early phase relapsing–remitting (RRMS) while there are no treatments patients that progress neither to chronic nor primary form disease. In this manuscript, we have studied therapeutic efficacy cell gene therapy strategy treatment mouse...
Abstract Conditional transgene expression in human stem cells has been difficult to achieve due the low efficiency of existing delivery methods, strong silencing transgenes and toxicity regulators. Most technologies are based on clones expressing appropriate levels tTA or rtTA transactivators (based TetR-VP16 chimeras). In present study, we aim generation Tet-On all-in-one lentiviral vectors (LVs) that tightly regulate using original TetR repressor. By promoter combinations shielding LVs...