A5037987675- Spinal Cord Injury Research
- Spinal Dysraphism and Malformations
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Cardiac Arrest and Resuscitation
- Nitric Oxide and Endothelin Effects
- Antibiotics Pharmacokinetics and Efficacy
- Cerebrospinal fluid and hydrocephalus
- Neuroscience of respiration and sleep
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurogenetic and Muscular Disorders Research
- Cardiac Ischemia and Reperfusion
- Neurogenesis and neuroplasticity mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Peroxisome Proliferator-Activated Receptors
- Mesenchymal stem cell research
- Cardiovascular Issues in Pregnancy
- Pharmacological Effects and Toxicity Studies
- Pain Mechanisms and Treatments
- Spinal Hematomas and Complications
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Bone and Joint Diseases
- NF-κB Signaling Pathways
- Stroke Rehabilitation and Recovery
Hospital de Especialidades
2006-2024
Centro Medico Nacional Siglo XXI
2006-2024
Mexican Social Security Institute
2013-2023
National Medical Center
2009
Instituto Politécnico Nacional
2006
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
1994-1998
Center for Research and Advanced Studies of the National Polytechnic Institute
1992-1998
Universidad Nacional Autónoma de México
1994
Fetal ventral mesencephalon and fetal adrenal tissue grafted to the caudate nucleus of four three parkinsonian patients, respectively, have been shown be an alternative treatment for amelioration signs disease. The patients had a significant rigidity, bradykinesia, postural imbalance, gait disturbance, facial expression. Three these returned work. fatal group only showed rigidity bradykinesia. Though are now able perform their basic daily living activities, one them has renewed her household...
Spinal cord injury (SCI) is an incapacitating condition that affects motor, sensory, and autonomic functions. Since 1990, the only treatment administered in acute phase of SCI has been methylprednisolone (MP), a synthetic corticosteroid anti-inflammatory effects; however, its efficacy remains controversial. Although MP thought to help resolution edema, there are no scientific grounds support this assertion. Aquaporin 4 (AQP4), most abundant component water channels CNS, participates...
Individuals with Parkinson’s disease (PD) suffer from motor and mental disturbances due to degeneration of dopaminergic non-dopaminergic neuronal systems. Although they provide temporary symptom relief, current treatments fail control non-motor alterations or arrest progression. Aiming explore safety possible neuropsychological benefits a novel strategy improve the PD condition, case series study was designed for brain grafting human neural progenitor cells (NPCs) group eight patients...
To compare the effectiveness of cyclosporin-A (CsA) with methylprednisolone (MP) or a combination both upon inhibition lipid peroxidation (LP) after spinal cord (SC) injury, rats were treated either CsA, MP, CSA+MP vehicle starting 1 h SC contusion at T9 level. LP was assessed 24 injury by fluorescent product formation method. The survival rate also evaluated in other series Kaplan–Meier curves. Lipid similarly inhibited (p >0.05). Animals receiving MP (alone combined CsA) showed poorest...
Objectives. To study the efficacy and safety of 4‐aminopyridine (4‐AP), to document sensorimotor changes after discontinuation drug in patients with long‐term spinal cord injury. Design. Randomized, double‐blind, placebo‐controlled trial. Setting. Clinical research unit. Patients. Twenty‐seven Intervention. Patients were randomized receive either oral 4‐AP 5 mg/day, which was increased by mg/week a maximum dosage 30 or placebo for 12 weeks. They switched opposite treatment next Measurements...
Abstract After damage to the central nervous system (CNS) body is protected by an adaptive immune response which directed against myelin‐associated proteins. Active immunization with nonpathogenic derivatives of CNS‐associated peptides (DCAP) reduces degeneration neurons and promotes motor recovery after spinal cord injury (SCI) in rats. In order improve even more neurological outcome obtained this therapy, either a combination DCAP plus glutathione monoethyl ester (GSHE) or double were...
After spinal cord injury (SCI), a complex cascade of pathophysiological processes increases the primary damage. The inflammatory response plays key role in this pathology. Recent evidence suggests that myeloperoxidase (MPO), an enzyme produced and released by neutrophils, is special importance spreading tissue Dapsone (4,4′-diaminodiphenylsulfone) irreversible inhibitor MPO. Recently, we demonstrated, model brain ischemia/reperfusion, dapsone has antioxidant, antiinflammatory, antiapoptotic...
Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, communities; the financial costs can be challenging families health institutions. Treatments aimed at restoring spinal after injury, which have been tested animal models or clinical trials, generally seek to counteract one...
Spinal cord injury (SCI) produces multiple systemic and metabolic alterations. Although some alterations could be associated with ischemic organ damage, little is known about microvascular blood flow (MVBF) in organs other than the spinal after acute SCI. We used laser Doppler flowmetry anesthetized rats to assess MVBF several tissues before complete T-2 T-9 SCI at 1 h on days 1, 3, 7 post-SCI. Mean arterial pressure (MAP), heart rate hematologic variables also were recorded. MAP changes not...
Disability after traumatic spinal cord injury (TSCI) results from physical trauma and "secondary mechanisms of injury" such as low metabolic energy levels, oxidative damage lipid peroxidation. In order to prove if early reactivation is a better therapeutic option than antioxidant therapy in the acute phase TSCI, contusions were performed adult rats using well-characterized weight drop technique at thoracic 9 level. After pyrophosphate thiamine or non-degradable cocarboxylase (NDC) enzyme was...
The pharmacokinetics of the immunosuppressive agent cyclosporin-A (CsA) were studied in rats submitted to spinal cord (SC) injury. A single CsA 10 mg/kg dose was given either intraperitoneally (ip) or orally experimental SC injury at T8 level. Twenty four hours after lesion (acute stage injury) ip bioavailability increased, while t½ prolonged. However, oral reduced. Seven weeks (chronic bioavailability, by route, not significantly different from control values. Results indicate that...