A5011856721- Rheumatoid Arthritis Research and Therapies
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Vasculitis and related conditions
- Histiocytic Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- Ion channel regulation and function
- Eosinophilic Disorders and Syndromes
- Rabies epidemiology and control
- Atherosclerosis and Cardiovascular Diseases
- Ion Channels and Receptors
- Autoimmune and Inflammatory Disorders Research
- Dermatological and COVID-19 studies
- Pain Mechanisms and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Neurogenesis and neuroplasticity mechanisms
- Venomous Animal Envenomation and Studies
- Autoimmune Bullous Skin Diseases
- Sepsis Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Parvovirus B19 Infection Studies
- Cardiac tumors and thrombi
Hamilton Medical Center
2024
Instituto de Investigación Biosanitaria de Granada
2011-2023
Hospital Universitario Reina Sofía
2001-2019
Johns Hopkins Medicine
2013-2018
Johns Hopkins University
2013-2018
Czech Academy of Sciences, Institute of Physiology
2018
Rathenau Instituut
2017
Center for Rheumatology
2013
Hospital Universitario Virgen de las Nieves
2006-2011
Universidad de Granada
1999-2011
The hypothalamus is the central regulator of a broad range homeostatic and instinctive physiological processes, such as sleep-wake cycle, food intake, sexually dimorphic behaviors. These behaviors can be modified by various environmental cues, although molecular cellular mechanisms that mediate these effects remain poorly understood. Recently, it has become clear both juvenile adult exhibit ongoing neurogenesis, which serve to modify neural circuitry. In this report, we share new findings on...
Hypothalamic tanycytes, a radial glial-like ependymal cell population that expresses numerous genes selectively enriched in embryonic hypothalamic progenitors and adult neural stem cells, have recently been observed to serve as source of adult-born neurons the mammalian brain. The genetic mechanisms regulate specification maintenance tanycyte identity are unknown, but critical for understanding how these cells can act progenitor cells. We observe LIM (Lin-11, Isl-1, Mec-3)-homeodomain gene...
Itch (pruritis) and pain represent two distinct sensory modalities; yet both have evolved to alert us potentially harmful external stimuli. Compared with pain, our understanding of itch is still nascent. Here, we report a new clinical case debilitating altered perception resulting from the heterozygous de novo p.L811P gain-of-function mutation in NaV1.9, voltage-gated sodium (NaV) channel subtype that relays information periphery spine. To investigate role NaV1.9 itch, developed mouse line...
Este estudio investiga el impacto del comercio informal en crecimiento económico de la ciudad Quevedo 2024, abordando un fenómeno significativo que ha sido tradicionalmente marginado los análisis económicos convencionales. La investigación se basa una muestra representativa 348 trabajadores informales, empleando enfoque metodológico mixto combina métodos cuantitativos y cualitativos. Los hallazgos revelan no solo actúa como estrategia supervivencia para las comunidades con escasas...
Functional bowel disorder patients can suffer from chronic abdominal pain, likely due to visceral hypersensitivity mechanical stimuli. As there is only a limited understanding of the basis (CVH), drug-based management strategies are ill defined, vary considerably, and include NSAIDs, opioids, even anticonvulsants. We previously reported that 1.1 subtype voltage-gated sodium (NaV; NaV1.1) channel family regulates excitability sensory nerve fibers transmit pain message spinal cord. Herein, we...
AA (secondary) amyloidosis is one of the most severe and uncommon complications several rheumatic disorders chronic infections such as tuberculosis (TB). Successful treatment depends on control underlying inflammatory process, what can lead to an improvement or a regression in organ dysfunction. If disorder persists, it has been reported some cases secondary diseases, that use biologic therapy so far only opportunity reduce development reverse established deposits. We report herein case...
Background Biological therapies against tumor necrosis factor α have revolutionized the treatment of several inflammatory rheumatic diseases. However, 30% responders will present a clinical failure after having controlled disease for at least 6 months (secondary failure). may induce an unwanted immune response, which alter bioavailability drug causing loss response. Objective The objective this study was to assess correlation between secondary (based on Disease Activity Score in 28 Joints or...
Cellulosimicrobium cellulans has been reported as a rare cause of human pathogenesis. Infections mainly occur in immunocompromised patients and very often are associated with foreign body. We report the first case septic arthritis caused by C. an immunocompetent patient. Our patient suffered penetrating palm tree thorn injury to his left knee 8 weeks before admission. Although no objects were found, they suspected because previous reports suggest frequent association this microorganism, open...
Objective: To assess the efficacy and safety of tocilizumab (TCZ) in Caucasian patients with refractory Takayasu’s arteritis (TAK) clinical practice. Methods: A multicenter study TAK who received TCZ. The outcome variables were remission, glucocorticoid-sparing effect, improvement imaging techniques, adverse events. comparative between TCZ as monotherapy (TCZ MONO ) combined conventional disease modifying anti-rheumatic drugs (cDMARDs) COMBO was performed. Results: comprised 54 (46 women/8...
Medial ganglionic eminence-derived inhibitory GABAergic pallial interneurons (MGE-pINs) are essential regulators of cortical circuits; their dysfunction is associated with numerous neurological disorders. We developed human (h) MGE-pINs from pluripotent stem cells for the treatment drug-resistant epilepsy. Here, we analyzed xenografted hMGE-pINs over lifespan host mice using single nuclei RNA sequencing. Comparative transcriptomics against endogenous brain datasets revealed that 97% grafted...