Estéban Rubio
A5019951649- Vasculitis and related conditions
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Spondyloarthritis Studies and Treatments
- Urticaria and Related Conditions
- Otitis Media and Relapsing Polychondritis
- Renal Diseases and Glomerulopathies
- Platelet Disorders and Treatments
- Pregnancy and Medication Impact
- Systemic Sclerosis and Related Diseases
- Autoimmune Bullous Skin Diseases
- Cell Adhesion Molecules Research
- Reproductive System and Pregnancy
- Biosimilars and Bioanalytical Methods
- Inflammasome and immune disorders
- Plant and soil sciences
- Eosinophilic Esophagitis
- Abdominal vascular conditions and treatments
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Atherosclerosis and Cardiovascular Diseases
- Soil Science and Environmental Management
- Acute Lymphoblastic Leukemia research
Instituto Nacional de Tecnologia
2023-2024
National Agricultural Technology Institute
2023-2024
Hospital Universitario Virgen del Rocío
2014-2023
Universidad Complutense de Madrid
1998
Psoriatic arthritis (PsA) is a chronic inflammatory affecting up to 30% of patients with psoriasis (Ps). To date, most the known risk loci for PsA are shared Ps, and identifying disease-specific variation has proven very challenging. The objective present study was identify genetic specific PsA.We performed genome-wide association in cohort 835 1558 controls from Spain. Genetic tested at single marker level pathway level. Meta-analysis case-control 2847 individuals North America. confirm...
The genetic component of Immunoglobulin-A (IgA) vasculitis is still far to be elucidated. To increase the current knowledge on this we performed first genome-wide association study (GWAS) condition. 308 IgA patients and 1,018 healthy controls from Spain were genotyped by Illumina HumanCore BeadChips. Imputation GWAS data was using 1000 Genomes Project Phase III dataset as reference panel. After quality control filters imputation, 285 1,006 remained in datasets included further analysis....
Objective IgA vasculitis (Henoch‐Schönlein) (IgAV), formerly called Henoch‐Schönlein purpura, is the most common in children, but it not rare adults. Increased familial occurrence supports a genetic predisposition to IgAV. In this context, an association with HLA–DRB1*01 phenotype has been suggested Caucasian individuals However, data on potential of IgAV were based small case series. We undertook study further investigate by performing HLA–DRB1 genotyping largest series patients ever...
Very few data are available on predictors of minimal disease activity (MDA) in patients with recent-onset psoriatic arthritis (PsA). Such crucial, since the therapeutic measures used to change adverse course PsA more likely succeed if we intervene early. In present study, predictive models based machine learning detect variables associated achieving MDA PsA.We performed a multicenter observational prospective study (2-year follow-up, regular annual visits). The population comprised aged ≥18...
<h3>Objective</h3> Copy number variants (CNVs) have been associated with the risk to develop multiple autoimmune diseases. Our objective was identify CNVs psoriatic arthritis (PsA) using a genome-wide analysis approach. <h3>Methods</h3> A total of 835 patients PsA and 1498 healthy controls were genotyped for Illumina HumanHap610 BeadChip genotyping platform. Genomic characterised CNstream software analysed association χ<sup>2</sup> test. The most significant genomic CNV associations...
Ixekizumab (IXE) is an IgG4-type monoclonal antibody targeting IL-17A indicated alone or in combination with methotrexate, for the treatment of active psoriatic arthritis (PsA) adult patients insufficient response intolerance to one more disease-modifying anti-rheumatic drug (DMARD) therapy. The PRO-STIP study aimed describe persistence, patient characteristics, patterns, and effectiveness PsA receiving IXE a real-world clinical setting Spain. This was observational, multicentric,...
Objective: To assess the efficacy and safety of tocilizumab (TCZ) in Caucasian patients with refractory Takayasu’s arteritis (TAK) clinical practice. Methods: A multicenter study TAK who received TCZ. The outcome variables were remission, glucocorticoid-sparing effect, improvement imaging techniques, adverse events. comparative between TCZ as monotherapy (TCZ MONO ) combined conventional disease modifying anti-rheumatic drugs (cDMARDs) COMBO was performed. Results: comprised 54 (46 women/8...
Introduction: To determine whether the PTPN22 (protein tyrosine phosphatase nonreceptor 22)/CSK (c-src kinase) pathway is implicated in susceptibility and clinical heterogeneity of Henoch-Schönlein purpura (HSP) largest series Caucasian HSP patients ever assessed for genetic studies.Methods: A set 329 Spanish diagnosed with fulfilling American College Rheumatology Michel et al. classification criteria 515 sex ethnically matched controls were recruited this study.Two well-known CSK (CSK...
Cytokines signalling pathway genes are crucial factors of the genetic network underlying pathogenesis Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence interleukin (IL)33- IL1 receptor like (IL1RL)1 on increased risk several immune-mediated diseases has been described. Accordingly, we assessed whether IL33-IL1RL1 represents a novel factor for IgAV. Three tag polymorphisms within IL33 (rs3939286, rs7025417 and rs7044343) three IL1RL1 (rs2310173, rs13015714...
BAFF, APRIL and BAFF-R are key proteins involved in the development of B-lymphocytes autoimmunity. Additionally, BAFFR polymorphisms were associated with immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion genetic variant for several autoimmune diseases. Accordingly, we assessed whether represent novel risk factors Immunoglobulin-A vasculitis (IgAV), predominantly B-lymphocyte inflammatory condition. rs374039502, which colocalizes GCTGT>A, two tag variants within...
<h3>Background</h3> Non-infectious aortitis is often refractory to standard immunosuppressive therapy. IL-6 has been implicated in the pathogenesis of aortitis. <h3>Objectives</h3> Our aim was assess efficacy anti-IL6 receptor monoconal antibody tocilizumab (TCZ) a series patients with non-infectious <h3>Methods</h3> We reviewed 16 (14 women/2 men) diagnosed by imaging (CT angiography, MR and/or PET) that were treated TCZ. <h3>Results</h3> The mean age ± SD 51.4±20.1 years. underlying...
We aimed to develop recommendations for the management of methotrexate (MTX) when considering combination with biological (b) or targeted synthetic (ts) disease modifying drugs (DMARDs) in rheumatoid arthritis (RA).
El sustrato a base de compost corteza pino (SCCP) generalmente posee un pH inferior al rango adecuado para las plantas cultivadas en contenedor (5,3 6,5). En Misiones (Argentina), existen explotaciones rocas cuyo principal residuo es el polvo roca basáltica (PRB). objetivo del trabajo fue evaluar la capacidad PRB ajustar SCCP versus dolomita y valorar su respuesta solubilidad nutrientes. Se conformaron siete tratamientos: SCCP, con 1, 2 o 3 g L-1 0,74, 48 2,22 PRB. analizó porcentaje CaO,...