A5056059126- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Urticaria and Related Conditions
- Immunodeficiency and Autoimmune Disorders
- Autoimmune Bullous Skin Diseases
- Renal Transplantation Outcomes and Treatments
- Platelet Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Cell Adhesion Molecules Research
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genetic and Kidney Cyst Diseases
- Complement system in diseases
- Cardiovascular Health and Disease Prevention
- Pregnancy and preeclampsia studies
- Systemic Sclerosis and Related Diseases
- Biomedical Research and Pathophysiology
- Ion Transport and Channel Regulation
- Organ Transplantation Techniques and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Otitis Media and Relapsing Polychondritis
- Infectious Disease Case Reports and Treatments
Marqués de Valdecilla University Hospital
2015-2024
Instituto de Investigación Marqués de Valdecilla
2016-2024
Hospital Universitari Germans Trias i Pujol
2023
Universidad de Cantabria
2015-2019
Pediatric Nephrology of Alabama
2009
C3 glomerulopathy is a complement-mediated disease arising from abnormalities in complement genes and/or antibodies against components. Previous studies showed that treatment with corticosteroids plus mycophenolate mofetil (MMF) was associated improved outcomes, although the genetic profile of these patients not systematically analyzed. This study aims to analyze main determinants progression and response this therapeutic regimen.We conducted retrospective, multicenter, observational cohort...
ABSTRACT Background The role of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in the management glomerular/systemic autoimmune diseases with proteinuria real-world clinical settings is unclear. Methods This a retrospective, observational, international cohort study. Adult patients biopsy-proven glomerular were included. main outcome was percentage reduction 24-h from SGLT2i initiation to 3, 6, 9 and 12 months. Secondary outcomes included change estimated filtration rate (eGFR), by type...
The association between a change in proteinuria over time and its impact on kidney prognosis has not been analysed complement component 3 (C3) glomerulopathy. This study aims to investigate the longitudinal risk of failure.This was retrospective, multicentre observational cohort 35 nephrology departments belonging Spanish Group for Study Glomerular Diseases. Patients diagnosed with C3 glomerulopathy 1995 2020 were enrolled. A joint modelling linear mixed-effects models applied assess...
Abstract Background IgA nephropathy (IgAN) may recur in kidney transplant recipients. B‐cell‐activating factor (BAFF), a proliferation‐inducing ligand (APRIL), and α‐defensins are involved the pathogenesis of native IgAN; however, their role on IgAN recurrence has not been previously analyzed. Methods Thirty‐five patients with who received our center between January 1, 1993, December 31, 2015, were included. Recurrence was diagnosed ruled out 14 11 patients, respectively, by indication...
Background: C3 glomerulopathy (C3G) is a rare kidney disease, which makes it difficult to collect large cohorts of patients better understand its variability. The aims this study were describe the clinical profiles and patterns progression disease. Methods: Retrospective, observational cohort study. Patients diagnosed with C3G between 1995–2020 enrolled. Study population was divided into by combining following predictors: eGFR under/above 30 ml/min/1.73m 2 fn2, proteinuria 3.5 g/day,...
Cytokines signalling pathway genes are crucial factors of the genetic network underlying pathogenesis Immunoglobulin-A vasculitis (IgAV), an inflammatory vascular condition. An influence interleukin (IL)33- IL1 receptor like (IL1RL)1 on increased risk several immune-mediated diseases has been described. Accordingly, we assessed whether IL33-IL1RL1 represents a novel factor for IgAV. Three tag polymorphisms within IL33 (rs3939286, rs7025417 and rs7044343) three IL1RL1 (rs2310173, rs13015714...
BACKGROUND:High blood pressure (BP) after kidney transplantation decreases graft and patient survival. There is a causal relationship between high salt intake increased BP in the general population, but role of on post-transplant hypertension remains controversial. The aims our study were to determine pattern first year post-transplantation its influence transplant population. MATERIAL AND METHODS:We selected 270 deceased-donor recipients with survival longer than 1 at least adequate 24-h...
BAFF, APRIL and BAFF-R are key proteins involved in the development of B-lymphocytes autoimmunity. Additionally, BAFFR polymorphisms were associated with immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion genetic variant for several autoimmune diseases. Accordingly, we assessed whether represent novel risk factors Immunoglobulin-A vasculitis (IgAV), predominantly B-lymphocyte inflammatory condition. rs374039502, which colocalizes GCTGT>A, two tag variants within...
Mycobacterium xenopi is an unusual pathogen and few such cases have been reported in the literature. We report case of a patient with sirolimus-based immunosuppressive regimen, who developed lung cavitation. M. was isolated from sputum. The treated initially rifampicin, isoniazid, pyrazinamide; levofloxacin added to treatment regimen after demonstrated. A possible relationship between sirolimus infection has postulated, probably due combination pulmonary toxicity cellular immunosuppression rapamycin.
C3 glomerulopathy is a rare and heterogeneous complement-driven disease. It often challenging to accurately predict in clinical practice the individual kidney prognosis at baseline. We herein sought develop validate prognostic nomogram long-term survival.We conducted retrospective, multicenter observational cohort study 35 nephrology departments belonging Spanish Group for Study of Glomerular Diseases. The dataset was randomly divided into training group (n = 87) validation 28). least...
About 25% of patients with IgA nephropathy (IgAN) progress to stage 5 chronic kidney disease (CKD) after years evolution. Various tools have been developed in recent designed predict which the will had poorer outcomes. The value circulating galactosyl-deficient IgA1 (Gd-IgA1) has related a worse evolution IgAN several studies. There are also some publications that relate higher APRIL values Recently, new method allows measuring Gd-IgA1 simpler way than those previously available. objective...
Abstract ANCA-associated vasculitis (AAV) comprises a group of necrotizing that mainly affects small- and medium-sized vessels. Serum anti-neutrophil cytoplasmic antibodies (ANCA), anti-myeloperoxidase (anti-MPO) anti-proteinase 3 (anti-PR3), levels may correlate to severity, prognosis, recurrence the disease. A retrospective analysis 101 patients with MPO-positive 54 PR3-positive was performed, using laboratory established cut-off value, measured by chemiluminescence. Furthermore, data...
IgA nephropathy (IgAN) is the most common and heterogeneous glomerular nephropathy. Several strategies have been used to determine risk of progression ESRD. We evaluate prognostic significance correlate IgAN calculator (IgANPC) Oxford/MEST-C score in our population.We performed a retrospective study biopsied patients with diagnosis from 1990 2015. classified biopsies using MEST-C we correlated clinical evolution. also calculated online IgANPC at time biopsy.We analysed 48 biopsies, 83% which...
IgA nephropathy (IgAN) is the most common and heterogeneous glomerular nephropathy. Several strategies have been used to determine risk of progression ESRD. We evaluate prognostic significance correlate IgAN calculator (IgANPC) Oxford/MEST-C score in our population. performed a retrospective study biopsied patients with diagnosis from 1990 2015. classified biopsies using MEST-C we correlated clinical evolution. also calculated online IgANPC at time biopsy. analyzed 48 biopsies, 83% which...
<h3>Background:</h3> Immunoglobulin-A vasculitis (IgAV) is an inflammatory vascular disease [1, 2]. The defining pathophysiologic feature of this the elevated levels aberrantly glycosylated galactose-deficient IgA (gd-IgA1) in circulation [3]. These gd-IgA1 lead to glycan-specific IgG antibody development [4], which forms circulating <i>IgA1-IgG anti-IgA1</i> immune complexes that ultimately deposit different tissues, causing inflammation [1]. Consequently, B-cells are proposed as crucial...
<h3>Background:</h3> Immunoglobulin A Vasculitis (IgAV) is an inflammatory disease caused by the accumulation of immune complexes IgA in walls small blood vessels skin, joints, gut, and kidney [1,2]. Likewise, Nephropathy (IgAN) characterized deposition complexes, although IgAN limited to kidney. Interestingly, nephritis IgAV (IgAVN) indistinguishable from IgAN. One factor that many nephropathies share, including IgAN, activation NLR family pyrin domain-containing 3 (NLRP3) protein, one...
<h3>Background:</h3> Immunoglobin A (IgA) vasculitis (IgAV) and anti-neutrophil cytoplasmic antibody (ANCA)-associated (AAV) are small vessel vasculitis. IgAV is characterized by IgA1-dominant immune complexes deposition at walls (Type III hypersensitivity reaction). By contrast, AAV mediated ANCA II Therefore, immunological pathogenesis very different. Renal involvement a common potentially severe manifestation in both diseases. <h3>Objectives:</h3> To compare a) analytical findings b)...
Background: Cytokines signaling pathway genes represent a key component of the genetic network implicated in pathogenesis Immunoglobulin-A vasculitis (IgAV) [1], an inflammatory vascular pathology. Interleukin (IL)17A is risk locus for autoimmune diseases, such as giant cell arteritis [2] and spondyloarthritis [3]. Objectives: To determine potential influence IL17A on IgAV. Methods: Five tag polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 rs7747909) were genotyped 360 Caucasian...
ITGAM–ITGAX (rs11150612, rs11574637), VAV3 rs17019602, CARD9 rs4077515, DEFA (rs2738048, rs10086568), and HORMAD2 rs2412971 are mucosal immune defence polymorphisms, that have an impact on IgA production, described as risk loci for nephropathy (IgAN). Since IgAN Immunoglobulin-A vasculitis (IgAV) share molecular mechanisms, with the aberrant deposit of IgA1 being main pathophysiologic feature both entities, we assessed potential influence seven abovementioned polymorphisms IgAV pathogenesis....
Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with high maternal and fetal morbidity mortality increased future risk cardiovascular complications. To analyze whether women who have had PE severe features in their higher arterial stiffness (AS) parameters than those whose course was without signs severity. Sixty-five developed during gestation were evaluated, divided into two groups: group or non-severe (n = 30) 35). Carotid-femoral pulse wave velocity (cfPWV), central...
About 25% of patients with IgA nephropathy (IgAN) progress to stage 5 chronic kidney disease (CKD) after years evolution. Various tools have been developed in recent designed predict which the will had poorer outcomes. The value circulating galactosyl-deficient IgA1 (Gd-IgA1) has related a worse evolution IgAN several studies. There are also some publications that relate higher APRIL values Recently, new method allows measuring Gd-IgA1 simpler way than those previously available. objective...