A5006855331- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Genetic and Kidney Cyst Diseases
- Renal and Vascular Pathologies
- GDF15 and Related Biomarkers
- Chronic Kidney Disease and Diabetes
- Nutrition and Health in Aging
- Fetal and Pediatric Neurological Disorders
- Autoimmune Bullous Skin Diseases
- Pregnancy and Medication Impact
- Cerebrospinal fluid and hydrocephalus
- SARS-CoV-2 and COVID-19 Research
- Biomedical Research and Pathophysiology
- Advancements in Battery Materials
- Animal Virus Infections Studies
- Nuclear Receptors and Signaling
- COVID-19 Clinical Research Studies
- Kidney Stones and Urolithiasis Treatments
- Potassium and Related Disorders
- Genetic Syndromes and Imprinting
- Ion Transport and Channel Regulation
- Organ and Tissue Transplantation Research
- Abdominal vascular conditions and treatments
Marqués de Valdecilla University Hospital
2018-2025
Instituto de Investigación Marqués de Valdecilla
2019-2025
Universidad de Cantabria
2020-2025
Charité - Universitätsmedizin Berlin
2021-2024
Biomedical Research Institute
2024
Humboldt-Universität zu Berlin
2022-2023
Freie Universität Berlin
2022-2023
German Society of Medical Intensive Care and Emergency Medicine
2023
Transplant recipients exhibit an impaired protective immunity after SARS-CoV-2 vaccination, potentially caused by mycophenolate (MPA) immunosuppression. Recent data from patients with autoimmune disorders suggest that temporary MPA hold might greatly improve booster vaccination outcomes. We applied a fourth dose of vaccine to 29 kidney transplant during (5 weeks) MPA/azathioprine hold, who had not mounted humoral immune response previous vaccinations. Seroconversion until day 32 was observed...
Solid phase immunoassays improved the detection and determination of antigen-specificity donor-specific antibodies (DSA) to human leukocyte antigens (HLA). The widespread use SPI in kidney transplantation also introduced new clinical dilemmas, such as whether patients should be monitored for DSA pre- or post-transplantation. Pretransplant screening through has become standard practice are readily determined case suspected rejection. However, monitoring recipients with stable graft function...
Abstract Background and hypothesis Donor-derived cell-free DNA (dd-cfDNA) shows good diagnostic performance for the detection of antibody-mediated rejection (AMR) in kidney transplant recipients (KTR). However, clinical benefits dd-cfDNA monitoring need to be established. Early diagnosis AMR at potentially reversible stages may increasingly important due emerging treatment options AMR. We hypothesized that KTR with de novo donor-specific anti-HLA antibodies (dnDSA) performing biopsy case...
Background/Objectives: New monitoring methods are being developed to improve the kidney transplant outcome. Among them, measurement of Torque Teno virus load (TTV load) has been associated with overall immunosuppressive status and percentage donor-derived circulating free DNA (dd-cfDNA) molecular graft injury, mainly related antibody-mediated rejection (AbMR). Both provide complementary information, but they have not previously used together for recipients (KTx). Methods: A prospective study...
Background. The aim of our study is to share experience with uncontrolled donation after the circulatory determination death (uDCDD) kidney transplantation and propose updated donor selection criteria for uDCDD programs. Methods. A prospective comparing recipients grafts from local donors standard neurological (DNDD) between 2013 2024. Donor acceptance was determined using a combination 3 factors: age, no-flow period, warm ischemic time (WIT). Normothermic regional perfusion preservation...
Background De novo donor-specific HLA antibodies (dnDSA) are key factors in the diagnosis of antibody-mediated rejection (ABMR) and related to graft loss. Methods This retrospective study was designed evaluate natural course dnDSA function kidney allograft survival assess impact mean fluorescence intensity (MFI) evolution as detected by annual Luminex ® screening. All 400 transplant recipients with 731 against last (01/03/2000-31/05/2021) were included. Results During 8.3 years follow-up,...
Abstract Transplant recipients exhibit an impaired protective immunity after SARS-CoV-2 vaccination, potentially caused by mycophenolate (MPA) immunosuppression. Recent data from autoimmune patients suggest that temporary MPA hold might significantly improve booster vaccination outcomes. We applied a fourth dose of vaccine during (5 weeks) to 29 kidney transplant recipients, who had not mounted humoral immune-response previous vaccinations. Seroconversion until day 32 was observed in 76%...
ABSTRACT Background De novo donor-specific antibodies (dnDSAs) may cause antibody-mediated rejection and graft dysfunction. Little is known about the clinical course after first detection of dnDSAs during screening in asymptomatic patients. We aimed to assess value estimated glomerular filtration rate (eGFR) proteinuria predict failure patients with their potential utility as surrogate endpoints. Methods All 400 kidney transplant recipients at our centre (1 March 2000–31 May 2021) were...
Immunosuppression withdrawal after graft failure seems to favor sensitization. A high percentage of calculated panel-reactive antibody (cPRA) and the development de novo donor specific antibodies (dnDSA) indicate human leukocyte antigen (HLA) sensitization may hinder option retransplantation. There are no established protocols on immunosuppressive treatment that should be maintained transplant failure. retrospective analysis including 77 patients who lost their first renal between 1 January...
Background Transplant glomerulopathy (TG) may indicate different disease entities including chronic AMR (antibody-mediated rejection). However, criteria have been frequently changed, and long-term outcomes of allografts with TG according to Banff 2017 rarely investigated. Methods 282 kidney allograft recipients biopsy-proven were retrospectively investigated diagnosed Banff'17 criteria: (cAMR, n = 72), active (cAAMR, 76) isolated (iTG, 134). Of which 25/72 (34.7%) patients cAMR group 46/76...
The Banff 2017 report permits the diagnosis of pure chronic antibody-mediated rejection (cAMR) in absence microcirculation inflammation. We retrospectively investigated renal allograft function and long-term outcomes 67 patients with cAMR, compared who received antihumoral therapy (cAMR-AHT, n = 21) without treatment (cAMRwo, 46). At baseline, cAMR-AHT group had more concomitant T-cell-mediated (9/46 (19.2%) vs. 10/21 (47.6%); p 0.04), a higher g-lesion score (0.4 ± 0.5 versus 0.1 0.3; 0.01)...
IgA nephropathy (IgAN) is the most common and heterogeneous glomerular nephropathy. Several strategies have been used to determine risk of progression ESRD. We evaluate prognostic significance correlate IgAN calculator (IgANPC) Oxford/MEST-C score in our population.We performed a retrospective study biopsied patients with diagnosis from 1990 2015. classified biopsies using MEST-C we correlated clinical evolution. also calculated online IgANPC at time biopsy.We analysed 48 biopsies, 83% which...
IgA nephropathy (IgAN) is the most common and heterogeneous glomerular nephropathy. Several strategies have been used to determine risk of progression ESRD. We evaluate prognostic significance correlate IgAN calculator (IgANPC) Oxford/MEST-C score in our population. performed a retrospective study biopsied patients with diagnosis from 1990 2015. classified biopsies using MEST-C we correlated clinical evolution. also calculated online IgANPC at time biopsy. analyzed 48 biopsies, 83% which...
Kidney transplantation implies a significant improvement in patient survival. Nevertheless, early mortality after transplant remains high. Growth differentiation factor 15 (GDF-15) is novel biomarker under study as predictor multiple scenarios. The aim of this to assess the utility GDF-15 predict survival kidney candidates. For purpose, 395 recipients with pretransplant stored serum samples were included. median was 5331.3 (50.49–16242.3) pg/mL. After mean 90.6 ± 41.5 months follow-up, 82...
<b><i>Introduction:</i></b> Pretransplant cardiac troponin I (cTNI) has demonstrated its predicting value in survival after kidney transplant. Growth differentiation factor 15 (GDF-15) is a biomarker currently studied as predictor of mortality and cardiovascular events (CVE) different scenarios. The aim this study was to compare the utility these two biomarkers prediction <b><i>Methods:</i></b> We included 359 transplants performed our center...
Proteinuria is the main predictor of kidney graft loss. However, there little information regarding consequences nephrotic proteinuria (NP) and syndrome (NS) after a transplant. We aimed to describe clinical histopathological characteristics recipients with nephrotic-range compare surveillance between those who developed NS did not. A total 204 patients (18.6% transplants in study period) NP, 68.1% them had NS. Of 110 underwent biopsy, 47.3% exhibited ABMR, 21.8% recurrence...
Abstract Background and Aims In 2020, European Kidney Function Consortium (EKFC) proposed a new equation that estimates glomerular filtration rate (GFR) in population. Using creatinine age, as well CKDEPI, EKFC gives an estimation which has been demonstrated to correlate better measured GFR, particularly at extreme ages. CKDEPI is the most common used our clinical practice. Few studies have compared with kidney transplant (KT) recipients. Our objective compare of GFR KT patients. Method We...
Abstract Background and Aims In 2020, European Kidney Function Consortium (EKFC) proposed a new equation that estimates glomerular filtration rate (GFR) in population. Few studies have compared EKFC with CKDEPI, particularly kidney transplant (KT) recipients. Chronic Disease (CKD) classification by KDIGO is used not only nephrologists who evaluate more parameters of function, but also every other specialist are going to be guided mainly this stage. Our objective compare CKDEPI classifying...
Abstract Background and Aims Despite the improvement in renal transplant results, rate of graft loss from first year has improved poorly, antibody-mediated rejection (AbMR) being cause loss. Renal transplantation is usually monitored by measuring creatinine, proteinuria, immunosuppressive blood levels and, recently, donor specific antibodies polyomavirus load. However, currently only way to detect alloimmune damage perform a surveillance o indication biopsy. Non-invasive monitoring response...