A5017890175- Renal Transplantation Outcomes and Treatments
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Renal and Vascular Pathologies
- Organ Donation and Transplantation
- Artificial Intelligence in Healthcare and Education
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Transplantation: Methods and Outcomes
- Dialysis and Renal Disease Management
- Service-Oriented Architecture and Web Services
- Machine Learning in Healthcare
- Electronic Health Records Systems
- Biomedical Text Mining and Ontologies
- Polyomavirus and related diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Natural Language Processing Techniques
- Topic Modeling
- Plant Pathogens and Fungal Diseases
- Neurological Complications and Syndromes
- Renal Diseases and Glomerulopathies
- SARS-CoV-2 detection and testing
- Pregnancy and Medication Impact
- Neutropenia and Cancer Infections
Charité - Universitätsmedizin Berlin
2020-2024
Freie Universität Berlin
2020-2024
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2021-2024
Humboldt-Universität zu Berlin
2020-2024
Leibniz University Hannover
2023
German Society of Medical Intensive Care and Emergency Medicine
2022
Humboldt State University
2020
Medical University of Graz
2012-2018
Universitätsklinikum Erlangen
2014
ABSTRACT Galactomannan detection in bronchoalveolar lavage (BAL) fluid samples (GM test) is currently considered the gold standard test for diagnosing invasive pulmonary aspergillosis (IPA). The limitations, however, are various turnaround times and availability of testing. We compared performance GM testing with that conventional culture, an Aspergillus lateral-flow-device (LFD) test, a beta- d -glucan (BDG) PCR assay by using BAL from immunocompromised patients. A total 78 patients at risk...
Few studies have thoroughly investigated the causes of kidney graft loss (GL), despite its importance.A novel approach assigns each persistent and relevant decline in renal function over lifetime a allograft to standardized category, hypothesizing that singular or multiple events finally lead GL. An adjudication committee three physicians retrospectively evaluated indication biopsies, laboratory testing, medical history all 303 GLs among 1642 recipients transplants between January 1, 1997...
ABSTRACT Voriconazole plasma concentrations (VPCs) vary widely, and outside the therapeutic range are associated with either worse outcome in invasive aspergillosis (IA) or increased toxicity. The primary goal of this cohort study conducted a real-life setting was to identify potential factors inadequate VPCs ICU patients hematological malignancies. Within period 12 months, trough were obtained analyzed high-performance liquid chromatography, adequate defined as 1.5 5.5 mg/liter. <1.5...
The study evaluated the newly formatted Aspergillus-specific lateral-flow-device (LFD), and compared its performance to original prototype "old" LFD test using BALF samples from 28 patients (14 with probable/proven invasive pulmonary aspergillosis [IPA] 14 no evidence for IPA). A total of 10/14 (71%) IPA resulted positive new LFD, including 8/9 true-positive 2/5 false-negative results old LFD. All without negative LFD; specificity was significantly improved
TBase is an electronic health record (EHR) for kidney transplant recipients (KTR) combining automated data entry of key clinical (e.g., laboratory values, medical reports, radiology and pathology data) via standardized interfaces with manual during routine treatment notes, medication list, transplantation data). By this means, a comprehensive database KTR created benefits care research. It enables both easy everyday use quick access research questions highest quality. This achieved by the...
Early diagnosis of invasive aspergillosis (IA) remains challenging, with available diagnostics being limited by inadequate sensitivities and specificities. Triacetylfusarinine C, a fungal siderophore that has been shown to accumulate in urine animal models, is potential new biomarker for IA.
Summary Data on diagnostic performance of Galactomannan ( GM ) testing in patients under mould‐active regimens are limited. Whether sensitivity for diagnosing breakthrough invasive aspergillosis (IA) is decreased antifungal prophylaxis/therapy remains therefore a point discussion. We retrospectively analysed test results who were admitted with underlying haematological malignancies to two Divisions the Medical University Hospital Graz, Austria, between 2009 and 2012. Only cases probable...
Summary Combination of mannan antigen and anti‐mannan antibody (Mn/A‐Mn) testing has been reported a useful specific strategy for diagnosis invasive Candida infections ( ICI s). We evaluated Mn/A‐Mn as screening tool in patients with haematological malignancies. This clinical prospective study was performed at the Division Hematology, Medical University Graz, Austria between July December 2012. Patients risk fungal infection were included into twice weekly screened by testing, yielding 650...
Patient care after kidney transplantation requires integration of complex information to make informed decisions on risk constellations. Many machine learning models have been developed for detecting patient outcomes in the past years. However, performance metrics alone do not determine practical utility. We present a newly clinical decision support system (CDSS) detection patients at rejection and death-censored graft failure. The CDSS is based routine data including 1,516 transplant...
Artificial intelligence-driven decision support systems (AI-DSS) have the potential to help physicians analyze data and facilitate search for a correct diagnosis or suitable intervention. The of such is often emphasized. However, implementation in clinical practice deserves continuous attention. This article aims shed light on needs challenges arising from use AI-DSS physicians' perspectives.The basis this study qualitative content analysis expert interviews with experienced nephrologists...
ABSTRACT Low posaconazole plasma concentrations (PPCs) have been associated with breakthrough invasive fungal infections. We assessed the correlation between pre-steady-state PPCs (obtained days 3 and 5) obtained during steady state in 48 patients underlying hematological malignancies receiving oral-solution prophylaxis. Pre-steady-state correlated significantly at (Spearman r = 0.754; P < 0.001). Receiver operating characteristic (ROC) curve analysis of revealed an area under (AUC) 0.884...
Testing for serum galactomannan (GM) has been established as an important method diagnosing invasive aspergillosis (IA); however, limited data exist regarding the application of urine GM testing. The objective this study was to evaluate performance screening specimens and compare results with GM. performed between July 2012 March 2013 in adult patients underlying hematological malignancies who were hospitalized at Medical University Graz, Austria. Serum samples collected tested twice weekly...
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 denotes a global health issue. Data regarding COVID-19 incidence in kidney transplant recipients (KTR) are sparse. From 19 March to May 2020, we performed systematic screening for KTR. Tests included serum analysis antibodies using S protein-based immunofluorescence, anti-SARS-CoV-2 S1 immunoglobulin G (IgG) and A (IgA) enzyme-linked immunosorbent assays (ELISA), and/or quantitative reverse transcription polymerase chain...
High numbers of unknown classifications and inconsistent methodologies in previous studies make the interpretation causes leading to graft loss difficult. In addition, data on a holistic view looking at both death with functioning (DWFG) death-censored failure (DCGF) are sparse.In this single-centre study we included 1477 adult kidney transplants performed between 1997 2017, which all 286 DWFGs until end observation were analysed for assigned. Additionally, results compared 303 DCGFs same...
Summary Serum 1,3‐beta‐ d ‐glucan ( BDG ) testing is an established diagnostic marker for invasive fungal infections IFI among patients with haematological malignancies. In contrast limited data exist regarding the application of urine testing. Same‐day midstream and serum screening samples were collected in adult underlying A total 80 from 46 investigated: Twenty‐six had positive corresponding >120 pg ml −1 , 27 intermediate (60–80 ), negative (<25 ). significant correlation between...
Catheter-related bloodstream infections (CRBSIs) are currently detected in patients with clinically suspicion. The aim of our study was to evaluate whether CRBSIs could be anticipated and a subclinical stage by peptide nucleic acid fluorescence situ hybridization (PNA FISH) using universal probes or acridine orange leucocyte cytospin (AOLC) tests haematooncological central venous catheters (CVCs) situ.Peptide AOLC blood samples from one CVC lumen/port chamber were continuously performed....
The number of patients returning to dialysis after graft failure increases. Surprisingly, little is known about the clinical and immunological outcomes this cohort. We retrospectively analyzed 254 kidney allograft loss between 1997 2017 report such as mortality, relisting, retransplantations, transplant nephrectomies, immunization status. Of patients, 49% had died 5 years loss, while 27% were relisted, 14% on not only 11% retransplanted loss. In complete observational period, 111/254 (43.7%)...
The MACCS (Medical Assistant for Chronic Care Service) platform enables secure sharing of key medical information between patients after kidney transplantation and physicians. Patients provide such as vital signs, well-being, medication intake via smartphone apps. is transferred directly into a database electronic health record at the transplant center, which used routine patient care research. Physicians can send an updated plan laboratory data to app this platform. Other features are...
Scientific publications about the application of machine learning models in healthcare often focus on improving performance metrics. However, beyond short-lived improvements, many additional aspects need to be taken into consideration make sustainable progress. What does it take implement a clinical decision support system, what makes usable for domain experts, and brings eventually practical usage? So far, there has been little research answer these questions. This work presents...
Kidney transplant recipients (KTRs) show higher morbidity and mortality from COVID-19 than the general population have an impaired response to vaccination. We analyzed incidence clinical outcomes in a single-center cohort of approximately 2500 KTRs. Between 1 February 2020 July 2022, 578 KTRs were infected with SARS-CoV-2, 25 (4%) recurrent infections. In total, 208 (36%) hospitalized, 39 (7%) died. Among vaccinated patients, infection Omicron variant had 2%. Unvaccinated patients showed (9%...