A5057535648- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Autoimmune Bullous Skin Diseases
- Chronic Kidney Disease and Diabetes
- Mechanical Circulatory Support Devices
- Dermatological and COVID-19 studies
- Advanced Radiotherapy Techniques
- Renal Diseases and Glomerulopathies
- Advances in Oncology and Radiotherapy
- Transplantation: Methods and Outcomes
- Cancer Genomics and Diagnostics
- Corneal Surgery and Treatments
- Immunotherapy and Immune Responses
- Urinary and Genital Oncology Studies
- Cardiac Structural Anomalies and Repair
- Streptococcal Infections and Treatments
- Medical Imaging and Pathology Studies
- Pressure Ulcer Prevention and Management
- Neutropenia and Cancer Infections
- Microscopic Colitis
- Inflammatory Biomarkers in Disease Prognosis
- Fibroblast Growth Factor Research
- Ultrasound and Hyperthermia Applications
Hospital Universitario Puerta de Hierro Majadahonda
2010-2024
Institut Català d'Oncologia
2023
Hospital Universitario La Paz
2023
Centro de Investigación del Cáncer
2023
Instituto Oncológico Dr. Rosell
2023
Hospital Clínico Universitario de Valladolid
2023
Instituto de Investigación Biomédica de Málaga
2023
Universidad de Alcalá
2019-2021
Hospital Universitario de La Princesa
2020
Marqués de Valdecilla University Hospital
2019
Approximately 20% of patients with non-small-cell lung cancer (NSCLC) receive a diagnosis stage III disease. There is no current consensus regarding the most appropriate treatment for these patients.In this open-label, phase 2 trial, we randomly assigned resectable IIIA or IIIB NSCLC to neoadjuvant nivolumab plus platinum-based chemotherapy (experimental group) alone (control group), followed by surgery. Patients in experimental group who had R0 resections received adjuvant 6 months. The...
Neoadjuvant chemotherapy plus nivolumab has been shown to be effective in resectable non-small-cell lung cancer (NSCLC) the NADIM trial (ClinicalTrials.gov identifier: NCT03081689). The 3-year overall survival (OS) and circulating tumor DNA (ctDNA) analysis have not reported.This was an open-label, multicenter, single-arm, phase II which patients with stage IIIA NSCLC, who were deemed surgically resectable, treated neoadjuvant paclitaxel (200 mg/m2 once a day) carboplatin (area under curve...
Pulmonary megakaryocytes participate in the pathogenesis of lung damage, particularly acute injury. Although are not mentioned as a characteristic histologic finding associated to pulmonary injury, few studies reveal that their number is increased diffuse alveolar damage (DAD). In this autopsy study, we have observed relevant COVID-19 patients dying with injury (7.61 ± 5.59 per 25 high-power fields vs. 1.14 0.86 for control group, p < 0.05). We analyzed samples 18 patients, most whom died...
The aim of this study was to describe the testing rate and frequency molecular alterations observed in Lung Cancer Biomarker Testing Registry (LungPath).
Pressure ulcers are a prevalent health problem in today's society. The shortage of suitable animal models limits our understanding and ability to develop new therapies. This study aims report on the development novel reproducible human skin pressure ulcer model mice.Male non-obese, diabetic, severe combined immunodeficiency mice (n = 22) were engrafted with skin. A full-thickness graft was placed onto 4×3 cm wounds created dorsal mice. Two groups permanent grafts studied after 60 days....
Background Loss of human leukocyte antigen (HLA) class I expression and loss heterozygosity (LOH) are common events implicated in the primary resistance non-small cell lung cancer (NSCLC) to immunotherapy. However, there is no data on perioperative chemoimmunotherapy (ChIO) efficacy or response mechanisms context HLA defects. Methods Baseline tumor status (HLA-deficient (HLA-DEF) HLA-proficient (HLA-PRO)) was determined by DNA LOH combined with immunohistochemistry for protein levels tissue...
Pterygium is a conjunctival fibrovascular tissue growth on the cornea. The pathogenesis of pterygium involves several factors such as presence active angiogenic factors. Expansion lymphatic microvasculature has also been hypothesized. This study examines activity angiogenic/lymphangiogenic factor VEGF and expression vascular endothelial proteins in pterygia normal tissues.Primary grade 2 (n=20) conjunctiva biopsies were obtained during surgery after written informed consent. mRNA for CD31,...
Abstract Megakaryocytes are normally present in the lung where they play a role platelet homeostasis. The latter well known to participate pathogenesis of damage, particularly acute injury. Although megakaryocytes usually not mentioned as characteristic histopathologic finding associated pulmonary injury, few studies point out that their number is increased lungs patients with diffuse alveolar damage. In this autopsy study we have observed relevant COVID-19 dying respiratory distress...
Chronic complications of acute appendicitis managed in a conservative manner are not frequent. We present case lower gastrointestinal hemorrhage young patient with previous without surgical intervention. The colonoscopy detected an appendicular bleeding which was surgically treated. anatomopathological diagnosis granulomatous appendicitis. clinical evolution the favorable recurrence. Appendicular can be unusual complication-however potentially severe-of treated surgically.
IgA nephropathy (IgAN) is the most common and heterogeneous glomerular nephropathy. Several strategies have been used to determine risk of progression ESRD. We evaluate prognostic significance correlate IgAN calculator (IgANPC) Oxford/MEST-C score in our population.We performed a retrospective study biopsied patients with diagnosis from 1990 2015. classified biopsies using MEST-C we correlated clinical evolution. also calculated online IgANPC at time biopsy.We analysed 48 biopsies, 83% which...
IgA nephropathy (IgAN) is the most common and heterogeneous glomerular nephropathy. Several strategies have been used to determine risk of progression ESRD. We evaluate prognostic significance correlate IgAN calculator (IgANPC) Oxford/MEST-C score in our population. performed a retrospective study biopsied patients with diagnosis from 1990 2015. classified biopsies using MEST-C we correlated clinical evolution. also calculated online IgANPC at time biopsy. analyzed 48 biopsies, 83% which...
Abstract Introduction: The balance and composition of the gut microbiome play a pivotal role in modulating host immune system, they have been associated with survival outcomes patients undergoing immunotherapy-based treatments immune-related adverse events. In this study, our objective was to analyze fecal microbiota non-small-cell lung cancer (NSCLC) locally advanced disease neoadjuvant chemo-immunotherapy (IO-CT). Methods patients: Baseline stool samples were collected from 86 resectable...
The aim of this study is to extend the analysis Lung Cancer Biomarker Testing Registry (LungPath), by analysing techniques used in determination epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1) and programmed death ligand-1 (PD-L1) for diagnostic patients with advanced non-small-cell lung cancer (NSCLC).Information technique EGFR, ALK, ROS1 PD-L1 was recorded from March 2018 January 2019 44 centres, but only 34 centres matched 38 previously...
En la historia del trasplante cardíaco siempre ha estado inmerso el fallo primario injerto. Curiosamente, a medida que han ido pasando los años sido una entidad en aumento debido cambios receptores y donantes. Se definió como injerto (FPI) disfunción sistólica grave uni o biventricular con compromiso hemodinámico las primeras horas tras trasplante. Vamos intentar analizar características de pacientes sufrido FPI nuestro centro 783 trasplantes realizados hasta este momento Resultados (Tabla...