A5047740542- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Renal and Vascular Pathologies
- Complement system in diseases
- Organ Transplantation Techniques and Outcomes
- Vasculitis and related conditions
- Transplantation: Methods and Outcomes
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Pregnancy and Medication Impact
- Hormonal Regulation and Hypertension
- Organ Donation and Transplantation
- Systemic Sclerosis and Related Diseases
- Advanced Proteomics Techniques and Applications
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Platelet Disorders and Treatments
- Renin-Angiotensin System Studies
- Diabetes and associated disorders
- Genetic Associations and Epidemiology
- Metabolism, Diabetes, and Cancer
- Neurological Complications and Syndromes
- Metabolism and Genetic Disorders
Hospital de Sant Joan Despí Moisès Broggi
2019-2024
Vall d'Hebron Hospital Universitari
2014-2018
Universitat Autònoma de Barcelona
2009-2017
Hospital Universitari Germans Trias i Pujol
2009-2017
Hospital Valle del Nalón
2015
University of Bari Aldo Moro
2012
Inserm
2012
Nagoya University
2012
Bellvitge University Hospital
2003-2011
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2011
The long-term clinical evolution of prediabetes and post-transplant diabetes mellitus (PTDM) is unknown. We analysed, in this cohort study, the reversibility, stability progression PTDM 672 patients using repeated oral glucose tolerance tests (OGTTs) for ≤5 years. Most were on tacrolimus, steroids mycophenolate. About half developed either or prediabetes. incidence was 32% bimodal: early (≤3 months) late PTDM. Early reverted 31%; with use OGTTs necessary to detect around Pretransplant...
ABSTRACT Background The role of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in the management glomerular/systemic autoimmune diseases with proteinuria real-world clinical settings is unclear. Methods This a retrospective, observational, international cohort study. Adult patients biopsy-proven glomerular were included. main outcome was percentage reduction 24-h from SGLT2i initiation to 3, 6, 9 and 12 months. Secondary outcomes included change estimated filtration rate (eGFR), by type...
Background. Tacrolimus-based immunosuppression, the most widely used regimen in kidney transplantation, increases risk of new onset diabetes after transplantation (NODAT). However, prevalence, evolution and factors different prediabetic alterations: impaired fasting glucose, glucose tolerance, provisional diabetes, have not been established. Methods. In this multicenter prospective study we evaluated 154 nondiabetic transplant recipients receiving tacrolimus, mycophenolate mofetil low dose...
Abstract The survival after renal transplantation of patients with antineutrophil cytoplasmic antibody ( ANCA )‐associated to systemic vasculitis is as good in other diseases, although most the reports are based on small numbers patients. Furthermore, it not known whether comorbidities (cardiovascular [ CV ] disease and cancer) more frequent than general population. We report our experience analysis published data this topic. outcome 49 ‐associated vessel was compared a control group....
Cardiovascular disease is the major cause of morbidity and mortality after renal transplantation. It has been shown that both traditional transplant-specific risk factors contribute to high cardiovascular burden transplantation The aim evaluate association among ambulatory blood pressure monitoring (ABPM) at 3 months, inflammation graft outcome.ABPM months was performed in 126 consecutive transplants. According nocturnal reduction systolic (SBP), dipper (ΔSBP ≥ 10%), non-dipper (0 < ΔSBP...
Abstract Background Diabetic patients with kidney disease have a high prevalence of non-diabetic renal (NDRD). Renal and patient survival regarding the diagnosis diabetic nephropathy (DN) or NDRD not been widely studied. The aim our study is to evaluate in diabetes determine capacity clinical analytical data prediction NDRD. In addition, we will prognosis according biopsy findings diabetes. Methods Retrospective multicentre observational biopsies performed from 2002 2014. Results total, 832...
Background. Protocol biopsies performed in stable renal allografts show different degrees of acute and chronic lesions that have been related with graft outcome. However, the utility protocol to manage baseline immunosuppression has not well characterized. Methods. We a case-control study compare histological observed 49 patients treated tacrolimus (TAC), mycophenolate mofetil (MMF), prednisone cyclosporine Neoral (CsA), MMF, prednisone. Histological were graded according 1997 Banff...
Patients with a protocol renal allograft biopsy simultaneously displaying interstitial fibrosis/tubular atrophy (IF/TA) and subclinical rejection (SCR) have shortened graft survival than patients normal biopsy, or only IF/TA SCR. The poor outcome of these could be related more severe inflammation. We evaluate the immunophenotype infiltrating cells in diagnostic categories. Nonexhausted paraffin blocks from biopsies done during first year were stained anti-CD45, CD3, CD20, CD68 CD15...
Background. There is a lack of new therapeutic strategies for IgA nephropathy. Low-dose sirolimus inhibits mesangial cell proliferation and renal fibrosis in animal models. Methods. We performed pilot, randomized controlled trial to evaluate the efficacy safety low-dose patients with high-risk Twenty-three glomerular filtration rate (GFR) within 30–60 mL/min and/or proteinuria >1 g/day were randomly assigned plus enalapril atorvastatin (SRL group, n = 14) or (CONTROL 9). Primary composite...
Minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) are glomerular diseases characterized by nephrotic syndrome. Their diagnosis requires a renal biopsy, but it is an invasive procedure with potential complications. In small biopsy sample, where only normal glomeruli observed, FSGS cannot be differentiated from MCD. The correct crucial to effective treatment, as MCD normally responsive steroid therapy, whereas usually resistant. purpose of our study was...
<i>Background/Aims:</i> Glomerular kidney disease (GKD) is suspected in patients based on proteinuria, but its diagnosis relies primarily renal biopsy. We used urine peptide profiling as a noninvasive means to link GKD-associated changes each glomerular entity. <i>Methods:</i> Urinary profiles of 60 biopsy-proven and 14 controls were analyzed by combining magnetic bead enrichment, MALDI-TOF MS analysis, ClinProTools v2.0 select differential peptides. Tentative...
Background. Podocyte proteins are involved in the pathogenesis of glomerular kidney disease (GKD). However, there is little information on messenger RNA (mRNA) expression patterns B7-1 and NPHS1 urinary sediment patients with GKD. The objective this study was to analyse gene correlate it podocyte-specific genes Methods. Adult proliferative non-proliferative GKD, proteinuria stable renal function, were included. A group healthy subjects used determine normal levels markers obtain reference...
Complement alternative pathway dysregulation seems to be the pathophysiological basis of Dense Deposit Disease (DDD). Here, we describe a monoclonal anti-factor H (FH) autoantibody in woman diagnosed with DDD gammapathy. Enzyme-linked immunosorbent assays evidenced presence anti-FH antibodies patient's serum and showed that they were associated IgG-λ fraction. These autoantibodies recognize N-terminal region FH interfere its regulatory function. In summary, patient described here, activation...
Background Minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) are the main causes of idiopathic nephrotic syndrome in children adults, with diagnosis being essential for appropriate choice therapy requiring renal biopsy. However, presence only normal glomeruli on biopsy FSGS patients may lead to misclassification these as having MCD. The aim this study was (i) compare peptide profile MCD that a group healthy subjects, (ii) generate validate class prediction...
Abstract Background IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, leading to renal failure in 15% 40% of cases. IgAN diagnosed by biopsy, an invasive method that not risk-free. We used blood and urine peptide profiles as a noninvasive linking IgAN-associated changes with histological lesions Oxford classification. Methods prospectively studied 19 patients biopsy-proven 14 healthy subjects from 2006 2009, excluding crescentic collecting clinical biochemical...
Introduction. Infections and new onset diabetes mellitus after transplantation (NODAT) are frequent complications renal may be related to innate immunity alterations. We evaluate the relationship among serum mannose-binding lectin (MBL), chronic inflammation, NODAT, infection. Patients Methods. Between March 2005 October 2006, consecutive nondiabetic transplant recipients were recruited. MBL, soluble tumor necrosis factor receptor 2, neutrophil gelatinase-associated lipocalin determined...
Background Hypertension is one of the most prevalent cardiovascular risk factors in chronic kidney disease (CKD) and transplants. The contribution transplantation to hypertension comparison patients with CKD similar renal function has not been characterized. Methods Ninety-two transplants 97 an estimated glomerular filtration rate less than 60 mL/min/1.73 m2 receiving dialysis were enrolled. At entry, office blood pressure (BP) 24-hr ambulatory monitoring (ABPM) obtained. Results Office BP...
The clinical-histologic correlation in diabetic nephropathy is not completely known.We analyzed nephrectomy specimens from 90 patients with diabetes and diverse degrees of proteinuria glomerular filtration rate (GFR).Thirty-six (40%) subjects had normoalbuminuria, 33 (37%) microalbuminuria, 21 (23%) non-nephrotic proteinuria. Mean estimated GFR (eGFR) was 65±23 (40% <60 ml/min per 1.73 m2). About 170 glomeruli patient were analyzed, all samples included vascular tissue. Six (7%) classified...
Emerging information indicates that glucose metabolism alterations are common after renal transplantation and associated with carotid atheromatosis. The aims of this study were to investigate the prevalence different in stable recipients as well factors related condition.A multicenter, cross-sectional was conducted 374 transplant without pre- or posttransplantation diabetes. A standard 75-g oral tolerance test performed.Glucose present 119 (31.8%) recipients: 92 (24.6%) an abnormal 27 (7.2%)...
Up to 50-60% of patients with diabetes have non-diabetic kidney disease (NDKD) on biopsy. Diabetic retinopathy (DR) is a microvascular complication frequently associated diabetic nephropathy (DN). The objective the current study was investigate outcomes and survival in biopsy diagnoses DN NDKD according presence DR.We conducted an observational, multicentre retrospective pathological findings renal biopsies from 832 consecutive 2002 2014 18 nephrology departments. association DR replacement...