A5102905636- Psoriasis: Treatment and Pathogenesis
- Migraine and Headache Studies
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Cardiac electrophysiology and arrhythmias
- Psychosomatic Disorders and Their Treatments
- Ion channel regulation and function
- Health Systems, Economic Evaluations, Quality of Life
- Rheumatoid Arthritis Research and Therapies
- Genetic and Kidney Cyst Diseases
- Patient-Provider Communication in Healthcare
- Trigeminal Neuralgia and Treatments
- Renal and related cancers
- Dermatology and Skin Diseases
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Renal cell carcinoma treatment
- Neurotransmitter Receptor Influence on Behavior
- Pharmaceutical studies and practices
- Receptor Mechanisms and Signaling
- Educational Practices and Policies
- Vascular Malformations and Hemangiomas
- Neuroendocrine Tumor Research Advances
- Spanish History and Politics
- Cardiac Fibrosis and Remodeling
Eli Lilly (Spain)
2018-2024
Eli Lilly (United States)
2024
GEICAM – Spanish Breast Cancer Group
2022-2024
Ecological Society of America
2021
Instituto Nacional de Cancerología
2018
Universidad Complutense de Madrid
2013-2016
Hospital General Universitario Gregorio Marañón
2013-2016
Institut d'Investigacions Biomèdiques de Barcelona
2016
Consejo Superior de Investigaciones Científicas
2016
Universidad de Salamanca
2010-2013
Background— Atrial fibrillation is characterized by progressive atrial structural and electrical changes (atrial remodeling) that favor arrhythmia recurrence maintenance. Reduction of L-type Ca 2+ current ( I Ca,L ) density a hallmark the remodeling. Alterations in microRNAs could contribute to protein underlying fibrillation–induced This study was undertaken compare miR-21 levels isolated myocytes from appendages obtained patients sinus rhythm with chronic (CAF) determine whether channel...
Cardiac excitability and refractoriness are largely determined by the function number of inward rectifier K+ channels (Kir2.1–2.3), which differentially expressed in atria ventricles, Nav1.5 channels. We have focused on how Kir2.x within a macromolecular complex elucidating molecular determinants that govern Nav1.5/Kir2.x reciprocal modulation. The results demonstrate there is an unexpected 'internal' PDZ-like binding domain located at N-terminus channel mediates its to α1-syntrophin....
<b><i>Background:</i></b> The role of autosomal dominant polycystic kidney disease (ADPKD) as a risk factor for renal cell carcinoma (RCC) is still under discussion. Data on prevalence RCC in ADPKD are limited, especially large population scale. aim this study was to analyze the kidneys and characterize clinical features coincidence. <b><i>Methods:</i></b> Based our histopathological registry Else Kröner-Fresenius Registry, we retrospectively...
Atrial fibrillation (AF) produces rapid changes in the electrical properties of atria (electrical remodelling) that promote its own recurrence. In chronic AF (CAF) patients, up-regulation slow delayed rectifier K+ current (IKs) and down-regulation voltage-gated Ca2+ (ICa,L) are hallmarks remodelling critically contribute to abbreviation action potential duration atrial refractory period. Recent evidences suggested Pitx2c, a bicoid-related homeodomain transcription factor involved directing...
Abstract Background Migraine represents a serious burden for national health systems. However, preventive treatment is not optimally applied to reduce the severity and frequency of headache attacks related expenses. Our aim was assess persistence traditional migraine prophylaxis available in Spain its relationship with healthcare resource use (HRU) costs. Methods Retrospective observational study retrospective cohort design individuals treated oral medication first time from 01/01/2016...
Pancreatic islet cell tumors (ICTs) occur as sporadic neoplasias or a manifestation of multiple endocrine neoplasia type 1 (MEN1) and von Hippel–Lindau disease (VHL). Molecular classification ICTs is mandatory for timely diagnosis surveillance. Systematic comparison VHL-ICTs has been lacking. Our registry-based approaches used the German NET-Registry with 259 patients neuroendocrine (NETs), who were primarily diagnosed NETs, VHL-Registry 485 molecular genetically confirmed had undergone...
We hypothesize that some drugs, besides flecainide, increase the inward rectifier current (IK1) generated by Kir2.1 homotetramers (IKir2.1) and thus, exhibit pro- and/or antiarrhythmic effects particularly at ventricular level. To test this hypothesis, we analysed of propafenone, atenolol, dronedarone, timolol on Kir2.x channels. Currents were recorded with patch-clamp technique using whole-cell, inside-out, cell-attached configurations. Propafenone (0.1 nM–1 µM) did not modify either IK1 in...
This analysis aimed to evaluate demographics, migraine-related disability, symptoms, diagnosis and healthcare consultation, work productivity, treatment patterns according headache frequency in adults with migraine the OVERCOME (ObserVational survey of Epidemiology, tReatment Care Of MigrainE) (Spain) study.Data were obtained from an observational, cross-sectional, web-based conducted between October 2020-February 2021 Spain. Eligible participants adult members online panels living Spain who...
Baricitinib is an oral Janus kinase (JAK)1/JAK2 inhibitor approved to treat rheumatoid arthritis (RA). This study aimed investigate patients' characteristics, prescription patterns, effectiveness, and treatment persistence in patients receiving baricitinib real-world practice Spain.This retrospective longitudinal cohort conducted five rheumatology units included adults with RA initiating (Sep-2017-May-19) at least a 6-month-follow-up. Demographic/clinical changes disease activity pain level...
IntroductionWe functionally analyzed a frameshift mutation in the SCN5A gene encoding cardiac Na+ channels (Nav1.5) found proband with repeated episodes of ventricular fibrillation who presented bradycardia and paroxysmal atrial fibrillation. Seven relatives also carry showed Brugada syndrome an incomplete variable expression. The (p.D1816VfsX7) resulted severe truncation (201 residues) Nav1.5 C-terminus. Methods ResultsWild-type (WT) mutated together hNavβ1 were expressed CHO cells currents...
Ixekizumab (IXE) is an IgG4-type monoclonal antibody targeting IL-17A indicated alone or in combination with methotrexate, for the treatment of active psoriatic arthritis (PsA) adult patients insufficient response intolerance to one more disease-modifying anti-rheumatic drug (DMARD) therapy. The PRO-STIP study aimed describe persistence, patient characteristics, patterns, and effectiveness PsA receiving IXE a real-world clinical setting Spain. This was observational, multicentric,...
Psoriatic arthritis (PsA) is considered a multifaceted disease, with patients reporting low health-related quality of life (HRQoL). Data on disease burden are substantial and there exists need for properly designed studies to learn more about the evolution HRQoL in this condition. This study aims identify factors associated PsA followed-up real-world setting Spain. We conducted retrospective longitudinal observational including incident from rheumatology outpatient clinic Hospital Clínico...
Epidemiological, clinical and economic burden of alopecia areata in Spain: a real-world retrospective study. The PETALO studyBackground: Alopecia (AA) is chronic autoimmune disease that causes non-scarring hair loss.Data are lacking on the epidemiology AA Spain.Objectives: To estimate prevalence incidence Spain describe sociodemographic characteristics, treatment patterns, healthcare resource utilization (HCRU) associated costs.Materials & Methods: This was an observational, retrospective,...
Despite the abundance of data concerning biologic treatments for patients with psoriasis, clinicians are often challenged discerning optimal treatment each patient. To inform this selection, study explored whether a patient’s baseline characteristics or disease profile could predict likelihood achieving complete skin clearance treatment. Machine-learning and other statistical methods were applied to substantial collected from moderate-to-severe psoriasis in ongoing, international,...
The efficacy of galcanezumab has been demonstrated in randomized controlled trials, but evidence about its use under clinical practice conditions is still limited. This study aimed to describe the characteristics patients treated with routine Spain as well treatment patterns, persistence, and effectiveness. A retrospective chart review was carried out six hospitals. Information adults migraine, who started between November 2019 September 2021, analyzed until end or loss follow-up. Continuous...
We aimed to validate the Spanish version of Decisional Conflict Scale (DCS) and analyze its psychometric properties in people with migraine.The DCS validation comprised two phases. First, a translation cross-cultural adaptation following International Society for Pharmacoeconomics Outcomes Research (ISPOR) Good Practices: 1-preparation, 2-independent forward translation, 3-reconciliation, 4-back-translation, 5-harmonization, 6-clinical review, 7-content group migraine patients. Second,...
Currently, several biologic agents are available for the treatment of moderate-to-severe plaque psoriasis, including newer with similar mechanisms action and efficacy; therefore, there is a need to evaluate their efficiency in terms cost effectiveness.This study evaluates effectiveness recently approved interleukin (IL)-17A antagonists, ixekizumab secukinumab, psoriasis from perspective Spanish National Health System (NHS).A Markov model lifetime horizon was developed compare vs. secukinumab...
Psoriasis is a chronic inflammatory skin disease with an estimated prevalence in Spain of 2.3% the population. Approximately 30% patients have moderate-to-severe forms. Treatment biologic agents proving to be step forward management disease, although these treatments are very expensive. The objective this study was determine efficiency, terms cost per number needed treat (NNT), drugs available for treatment moderate severe plaque psoriasis. NNT data were obtained from network meta-analysis...