A5013949505- International Arbitration and Investment Law
- Parkinson's Disease Mechanisms and Treatments
- Taxation and Legal Issues
- Mediterranean and Iberian flora and fauna
- Neuropeptides and Animal Physiology
- Human Rights and Immigration
- Renin-Angiotensin System Studies
- Neuroendocrine regulation and behavior
- Neurotransmitter Receptor Influence on Behavior
- Historical and socio-economic studies of Spain and related regions
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- International Law and Aviation
- Marine Biology and Ecology Research
- Comparative constitutional jurisprudence studies
- Stress Responses and Cortisol
- Neurological diseases and metabolism
- Legal processes and jurisprudence
- Peptidase Inhibition and Analysis
- International Law and Human Rights
- RNA regulation and disease
- Marine Ecology and Invasive Species
- Comparative International Legal Studies
- Hormonal Regulation and Hypertension
- Memory and Neural Mechanisms
Universidad de Alcalá
2011-2025
Universidad de Granada
2013-2024
Instituto de Investigación Biosanitaria de Granada
2019-2022
Genomics England
2021
Hospital Universitario Fundación Jiménez Díaz
2020
Universidad Internacional
2017
Consejo Superior de Investigaciones Científicas
2008-2011
University of Alicante
2009
Instituto de Neurociencias
2004-2005
Cecil College
2005
We evaluated the role of melatonin in endotoxemia caused by lipopolysaccharide (LPS) unanesthetized rats. The expression inducible isoform nitric oxide synthase (iNOS) and increase oxidative stress seem to be responsible for failure lungs, liver, kidneys endotoxemia. Bacterial LPS (10 mg/kg b. w) was i.v. injected 6 h before rats were killed (10-60 b.w.) i.p. and/or after LPS. Endotoxemia associated with a significant rise serum levels aspartate alanine aminotransferases,...
Alpha-synuclein (alpha-syn) is an intracellular protein with a high tendency to aggregation. It the major component of Lewy bodies and may play key role in pathogenesis Parkinson's disease (PD). alpha-Syn also released by neurons can be detected biological fluids, such as plasma. The purpose this study was determine whether plasma alpha-syn concentrations are elevated newly diagnosed PD patients before treatment (nontreated group, ntPD; n = 53) compare them at least 1 year specific (tPD; 42)...
The Iberian Peninsula stands out as having variable levels of population admixture and isolation, making Spain an interesting setting for studying the genetic architecture neurodegenerative diseases.
Degeneration of nigrostriatal dopaminergic neurons is the major pathogenic substrate Parkinson's disease (PD). Inhibitors monoamine oxidase B (MAO‐B) have been used in treatment PD and at least one them, i.e., deprenyl, also displays antioxidant activity. Dopamine (DA) autoxidation produces reactive oxygen species implicated loss pathway. In this study we compared effects melatonin with those deprenyl vitamins E C preventing hydroxyl radical (•OH) generation during DA oxidation. The rate...
Reseña de la obra colectiva coordinada por Digno Montalván-Zambrano e Isabel Wences, La justicia detrás Justicia. Ideas y valores políticos en Corte Interamericana Derechos Humanos. Madrid: Marcial Pons, 2023, 302 pp.
Presentación del Anuario IELAT
Tryptophan is mainly metabolized in the brain through methoxyindole and kynurenine pathways. The pathway produces (among other compounds) melatonin, which displays inhibitory effects on human animal central nervous systems, including a significant attenuation of excitatory, glutamate‐mediated responses. kynurenines that interact with Nitric oxide (NO) increases glutamate release, melatonin may act via modification NO synthesis. In present study, four synthetic were studied activity rat...
Abstract: We examined the effect of melatonin on brain levels amino acids and nitric oxide (NO) after pentylenetetrazole (PTZ)‐induced seizures in rats. Animals were treated with (10–160 mg/kg, i.p.) 30 min before PTZ administration (100 s.c.), killed 3 hr later. At dose 80 significantly increased latency (5.7–12.7 min) decreased duration (31.2–18.4 s) first seizure, reducing induced mortality from 87.5 to 25%. After kill, brains removed neurotransmitters nitrite measured prefrontal cortex...
Abstract The effects of melatonin, amlodipine, diltiazem ( l ‐type Ca 2+ channel blockers) and ω‐conotoxin N blocker) on the glutamate‐dependent excitatory response striatal neurones to sensory‐motor cortex stimulation was studied in a total 111 neurones. Iontophoresis melatonin produced significant attenuation 85.2% with latency period 2 min. either ‐ or blocker also more than 50% recorded without latency. simultaneous iontophoresis + amlodipine did not increase by alone. However,...
The excitatory response to motor cortex stimulation of 201 striatal neurones was recorded electrophysiologically test the effects melatonin (aMT) and/or D1 and D2 antagonists. Iontophoresis aMT attenuated in 68.5% neurones, with a latency 2-4 min enhanced 11.9% neurones; 19.6% showed no change response. sulpiride (D2 antagonist) produced an immediate increase 62.8% attenuation 2.3% 34.9%. ejection counteracted aMT-dependent inhibition neurones. SCH-23390 (D1 iontophoresis had significant...