Margarita Rivera
A5017041542- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Bipolar Disorder and Treatment
- Birth, Development, and Health
- Genomic variations and chromosomal abnormalities
- Cardiovascular Disease and Adiposity
- Autism Spectrum Disorder Research
- Genetic Syndromes and Imprinting
- Diet and metabolism studies
- Genomics and Rare Diseases
- Schizophrenia research and treatment
- Epigenetics and DNA Methylation
- Cognitive Abilities and Testing
- Eating Disorders and Behaviors
- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Suicide and Self-Harm Studies
- Adolescent and Pediatric Healthcare
- Nutrition, Genetics, and Disease
- Mental Health Treatment and Access
- Nerve injury and regeneration
- Attention Deficit Hyperactivity Disorder
- Biosimilars and Bioanalytical Methods
- Rheumatoid Arthritis Research and Therapies
Universidad de Granada
2016-2025
Instituto de Investigación Biosanitaria de Granada
2015-2025
University of Utah
2023
Virginia Commonwealth University
2023
Huntsman (United States)
2023
El Colegio de México
2020-2022
King's College London
2012-2021
Medical Research Council
2014-2021
Lesbian, Gay, Bisexual and Transgender Community Center
2021
Massachusetts General Hospital
2019
Adversity, particularly in early life, can cause illness. Clues to the responsible mechanisms may lie with discovery of molecular signatures stress, some which include alterations an individual's somatic genome. Here, using genome sequences from 11,670 women, we observed a highly significant association between stress-related disease, major depression, and amount mtDNA (p = 9.00 × 10(-42), odds ratio 1.33 [95% confidence interval [CI] 1.29-1.37]) telomere length 2.84 10(-14), 0.85 CI...
Background Major depressive disorder (MDD) is a common and disabling condition with well-established heritability environmental risk factors. Gene–environment interaction studies in MDD have typically investigated candidate genes, though the known to be highly polygenic. This study aims test for between polygenic stressful life events (SLEs) or childhood trauma (CT) aetiology of MDD. Method The RADIANT UK sample consists 1605 cases 1064 controls SLE data, subset 240 272 CT data. Polygenic...
The association between major depressive disorder (MDD) and obesity may stem from shared immunometabolic mechanisms particularly evident in MDD with atypical features, characterized by increased appetite and/or weight (A/W) during an active episode.To determine whether subgroups of patients stratified according to the A/W criterion had a different degree genetic overlap obesity-related traits (body mass index [BMI] levels C-reactive protein [CRP] leptin).This multicenter study assembled...
Studies of major depression in twins and families have shown moderate to high heritability, but extensive molecular studies failed identify susceptibility genes convincingly. To detect genetic variants contributing depression, the authors performed a genome-wide association study using 1,636 cases ascertained U.K. 1,594 comparison subjects screened negative for psychiatric disorders.Cases were collected from 1) case-control recurrent (the Depression Case Control [DeCC] study; N=1346), 2) an...
Background Individuals with a mental health disorder appear to be at increased risk of medical illness. Aims To examine rates illnesses in patients bipolar ( n = 1720) and the clinical course illness according lifetime burden. Method Participants recruited within UK were asked about occurrence 20 illnesses, interviewed using Schedules for Clinical Assessment Neuropsychiatry (SCAN) diagnosed DSM-IV criteria. Results We found significantly several our sample. A high burden was associated...
A detailed understanding of the genome-wide variability single-nucleotide germline mutation rates is essential to studying human genome evolution. Here, we use ~36 million singleton variants from 3560 whole-genome sequences infer fine-scale patterns rate heterogeneity. Mutability jointly affected by adjacent nucleotide context and diverse genomic features surrounding region, including histone modifications, replication timing, recombination rate, sometimes suggesting specific mutagenic...
Epidemiological studies have recognized a genetic diathesis for suicidal behavior, which is independent of other psychiatric disorders. Genome-wide association (GWAS) on suicide attempt (SA) and ideation failed to identify specific variants. Here, we conduct further GWAS the first time, use polygenic score analysis in cohorts patients with mood disorders, test common variants disorders phenotypes. SA were conducted RADIANT GSK-Munich recurrent depression samples London Bipolar Affective...
Abstract Major depressive disorder (MDD) is a common, complex psychiatric and leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity genetic architecture have complicated efforts to detect associated risk variants. We combined single-nucleotide polymorphism (SNP) summary statistics from the CONVERGE PGC MDD, representing 10 502 Chinese (5282 cases 5220 controls) 18 663 European (9447 9215 subjects. determined fraction...
Obesity has been shown to be associated with depression and it suggested that higher body mass index (BMI) increases the risk of other common mental disorders. However, causal relationship remains unclear Mendelian randomisation, a form instrumental variable analysis, recently employed attempt resolve this issue.To investigate whether BMI major depression.Two analyses were conducted test between obesity in RADIANT, large case-control study depression. We used single nucleotide polymorphism...
Obesity is strongly associated with major depressive disorder (MDD) and various other diseases. Genome-wide association studies have identified multiple risk loci robustly body mass index (BMI). In this study, we aimed to investigate whether a genetic score (GRS) combining BMI might utility in prediction of obesity patients MDD. Linear logistic regression models were conducted predict obesity, respectively, three independent large case–control depression (Radiant, GSK-Munich, PsyCoLaus). The...
Abstract Previous reports and meta‐analyses have yielded inconclusive results as to whether the s/s genotype at 5‐HTTLPR serotonin transporter polymorphism confers increased risk for depression. We tested association between depression in a large cohort (n = 737) of Spanish primary care consecutive attendees participating European study on predictors (PREDICT study). Participants were administered Composite International Diagnostic Interview (CIDI) subscale allowing diagnoses using ICD‐10...
The presence of a genetic component to depression has been established by family, twin and, lesser extent, adoption studies. Family studies have shown that first-degree relatives patients with on average three times the risk those without family history disorder 1, but at least one study clinically ascertained narrowly defined estimated in siblings be nearly ten controls' 2. A systematic meta-analysis including data from five reported an heritability estimate 37% based provided over 70% 3....
Background Serotonin 1-A receptors are key regulators of serotonin activity and their dysregulation might be implicated in the emergence both major depression (MD) generalized anxiety disorder (GAD). Previous studies have yielded inconclusive results as to whether 5-HT1A receptor gene (HTR1A) has a role aetiology MD no study up date analysed this polymorphism on either pure or comorbid with GAD. Methods In study, 1059 patients taking part PREDICT-Gene were ascertained for Diagnostic...