A5004432810- Genetic Associations and Epidemiology
- Phosphodiesterase function and regulation
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Bipolar Disorder and Treatment
- Cognitive Abilities and Testing
- Epigenetics and DNA Methylation
- Renin-Angiotensin System Studies
- Birth, Development, and Health
- Genomic variations and chromosomal abnormalities
- Child and Adolescent Psychosocial and Emotional Development
- Livestock and Poultry Management
- Autism Spectrum Disorder Research
- Asthma and respiratory diseases
- Genomics and Rare Diseases
- Genetic Syndromes and Imprinting
- Adolescent and Pediatric Healthcare
- Genetic Mapping and Diversity in Plants and Animals
- Neuroscience and Neuropharmacology Research
- Congenital heart defects research
- Animal Nutrition and Physiology
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Cell Adhesion Molecules Research
- Nuclear Receptors and Signaling
Edinburgh Cancer Research
2022-2023
R&G Associates
2022
University of Edinburgh
2012-2021
Institute of Genetics and Cancer
2012-2020
Western General Hospital
2009-2019
University of Windsor
2019
Institute of Molecular Genetics
2019
University of California, San Diego
2019
Alzheimer Scotland
2016
Medical Research Council
2012-2014
The disrupted in schizophrenia 1 ( DISC1 ) gene is a candidate susceptibility factor for schizophrenia, but its mechanistic role the disorder unknown. Here we report that encoding phosphodiesterase 4B PDE4B by balanced translocation subject diagnosed with and relative chronic psychiatric illness. PDEs inactivate adenosine 3′,5′-monophosphate (cAMP), second messenger implicated learning, memory, mood. We show interacts UCR2 domain of elevation cellular cAMP leads to dissociation from an...
Cognitive impairment is common among individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit hyperactivity (ADHD). It has been suggested that some aspects of intelligence are preserved or even superior in people ASD compared controls, but consistent evidence lacking. Few studies have examined the genetic overlap between cognitive ability ASD/ADHD. The aim this study was to examine polygenic ASD/ADHD from general population. Polygenic risk for ADHD calculated...
In a project on the biodiversity of chickens funded by European Commission (EC), eight laboratories collaborated to assess genetic variation within and between 52 populations from wide range chicken types. Twenty-two di-nucleotide microsatellite markers were used genotype DNA pools 50 birds each population. The polymorphism measures for average, least polymorphic population (inbred C line) most (Gallus gallus spadiceus) were, respectively, as follows: number alleles per locus, population:...
The heritability of Major Depressive Disorder (MDD) has been estimated at 37% based largely on twin studies that rely contested assumptions. More recently, the MDD large populations from registries such as Swedish, Finnish, and Chinese cohorts. Family-based designs utilise a number different relationships provide an alternative means estimating heritability. Generation Scotland: Scottish Family Health Study (GS:SFHS) is (n = 20,198), family-based population study designed to identify genetic...
Stress is associated with poorer physical and mental health. To improve our understanding of this link, we performed genome-wide association studies (GWAS) depressive symptoms by environment interaction (GWEIS) stressful life events (SLE) in two UK population-based cohorts (Generation Scotland Biobank). No SNP was individually significant either GWAS, but gene-based tests identified six genes Biobank (DCC, ACSS3, DRD2, STAG1, FOXP2 KYNU; p < 2.77 × 10-6). Two SNPs GxE effects were GWEIS...
Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These often display co-morbidity low intelligence. Rare chromosomal deletions duplications these so it has suggested that or may be differences Here we investigate...
Depression has well-established influences from genetic and environmental risk factors. This led to the diathesis-stress theory, which assumes a multiplicative gene-by-environment interaction (GxE) effect on risk. Recently, Colodro-Conde et al. empirically tested this using polygenic score for major depressive disorder (PRS, genes) stressful life events (SLE, environment) effects symptoms, identifying significant GxE with an additive contribution liability. We have theory independent sample...