A5102985012- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Hormonal Regulation and Hypertension
- Neuroendocrine regulation and behavior
- Adrenal Hormones and Disorders
- Sleep and Wakefulness Research
- Heat shock proteins research
- Circadian rhythm and melatonin
- Genetics and Neurodevelopmental Disorders
- Bipolar Disorder and Treatment
- Estrogen and related hormone effects
- Receptor Mechanisms and Signaling
- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Schizophrenia research and treatment
- Genomic variations and chromosomal abnormalities
- Ion channel regulation and function
- Epigenetics and DNA Methylation
- 14-3-3 protein interactions
- Birth, Development, and Health
- Phosphodiesterase function and regulation
- Genomics and Rare Diseases
- Sleep and related disorders
Max Planck Institute of Psychiatry
2010-2025
HolsboerMaschmeyer NeuroChemie (Germany)
2018-2025
Max Planck Society
1998-2012
James Cook University
2009
Ludwig-Maximilians-Universität München
2009
Consejo Nacional de Investigaciones Científicas y Técnicas
2000
National Academies of Sciences, Engineering, and Medicine
2000
University of Freiburg
1988-1989
Johannes Gutenberg University Mainz
1988
Oxidative stress-induced neuronal cell death has been implicated in different neurological disorders and neurodegenerative diseases; one such ailment is Alzheimer's disease. Using the disease-associated amyloid beta protein, glutamate, hydrogen peroxide, buthionine sulfoximine, we investigated neuroprotective potential of estrogen against oxidative death. We show that 17-beta-estradiol, its nonestrogenic stereoisomer, 17-alpha-estradiol, some estradiol derivatives can prevent intracellular...
Context:The efficacy of antidepressant drug treatment in depression is unsatisfactory; 1 3 patients does not fully recover even after several trials.Genetic factors and clinical characteristics contribute to the failure a favorable outcome.Objective: To identify genetic determinants outcome depression.Design: Genomewide pharmacogenetic association study with 2 independent replication samples.Setting: We performed genomewide from Munich Antidepressant Response Signature (MARS) project pooled...
The effects of emotional stressors on the release arginine vasopressin (AVP) and oxytocin (OXT) within rat hypothalamus origin physiological significance AVP released hypothalamic paraventricular nucleus (PVN) were investigated. First, adult male Wistar rats with a microdialysis probe aimed at PVN or supraoptic exposed to either dominant (social defeat) novel cage. Release was significantly increased in response social defeat but not novelty. In contrast an activation...
Results from preclinical studies have validated the participation of neuropeptides in sleep regulation. In recent human and clinical it has been shown that peripheral administration various peptides results specific changes electroencephalogram humans. Furthermore, demonstrated certain are common regulators electrophysiological neuroendocrine components sleep. It is now well established balance between growth hormone-releasing hormone (GHRH) corticotropin-releasing (CRH) plays a key role...
Abstract The P2X7 receptor is an adenosine triphosphate (ATP)-gated ion channel expressed in different cell types of the brain. Polymorphisms P2RX7 gene have repeatedly been associated with psychiatric disorders including major depression. Depression a stress-related disorder which dysregulation immune system has attracted increasing attention as potential disease mechanism. well-documented role inflammatory conditions advocates its involvement and depression genesis. However, understanding...
Abstract The aim of the present study was to investigate physiological significance neuropeptide arginine vasopressin (AVP) released within septum, in behavioural response rats stress. In first experiment, were chronically implanted with a microdialysis probe aimed at mediolateral or ventral septum monitor local release AVP 10 min forced swimming 20 °C warm water. Exposure this stressor caused significant increase both (174 ± 21%, P < 0.01) and (220 33%, 0.01). contrast, microdialysates...
Interactions between the hypothalamic-pituitary-adrenocortical (HPA) system and melatonin secretion have been demonstrated, but only effects of on activity HPA studied in man. Alterations described as low-melatonin syndrome demonstrated patients suffering from a major depressive episode, an inhibitory factor has postulated. We investigated whether corticotropin-releasing hormone (CRH), which is thought to be involved abnormalities depressed patients, can also suppress healthy volunteers. Ten...
Background Although usually thought of as external environmental stressors, a significant heritable component has been reported for measures stressful life events (SLEs) in twin studies. Method We examined the variance SLEs captured by common genetic variants from genome-wide association study (GWAS) 2578 individuals. Genome-wide complex trait analysis (GCTA) was used to estimate phenotypic tagged single nucleotide polymorphisms (SNPs). also performed GWAS on number SLEs, and looked at...
The co-chaperone BAG-1 is involved in the regulation of steroid hormone receptors, including glucocorticoid receptor (GR). More recently, was found nucleus where it decreases GR transactivation. Moreover, nonspecific DNA binding has been reported. We discovered that N-terminal part BAG-1M, first 8 amino acids are sufficient for binding, containing a stretch three lysines and arginines. Changing spacing between these stretches had no effect on binding. Surprisingly, this small,...
Abstract The majority of genetic risk factors for major depressive disorder (MDD) still await identification. Since copy number variants (CNVs) have been implicated in various neuropsychiatric disorders, the question arises as to whether CNVs also play a role MDD. We performed genome‐wide CNV study using Illumina's SNP array data from 604 MDD patients and 1,643 controls. Putative were detected with algorithms QuantiSNP PennCNV. ≥30 consecutive SNPs log Bayes Factor/confidence value...