A5013625722- Respiratory viral infections research
- Influenza Virus Research Studies
- Transportation Planning and Optimization
- Suicide and Self-Harm Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Library Science and Administration
- Genetic Associations and Epidemiology
- Tryptophan and brain disorders
- Web and Library Services
- Child and Adolescent Psychosocial and Emotional Development
- Ubiquitin and proteasome pathways
- Viral Infections and Vectors
- Cancer-related gene regulation
- Optimization and Mathematical Programming
- Urban and Freight Transport Logistics
- Apelin-related biomedical research
- Traffic control and management
- Mental Health Treatment and Access
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health and Well-being Studies
- Mental Health Research Topics
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
Hebei Provincial Center for Disease Control and Prevention
2025
Shandong Mental Health Center
2011-2023
Lanzhou Jiaotong University
2011-2022
Shandong University
2013-2022
Anhui University
2013
GTx (United States)
2013
Guangdong Ocean University
2010-2012
Hengyang Academy of Agricultural Sciences
2011
Beihang University
2010
Hebei University
2010
Adversity, particularly in early life, can cause illness. Clues to the responsible mechanisms may lie with discovery of molecular signatures stress, some which include alterations an individual's somatic genome. Here, using genome sequences from 11,670 women, we observed a highly significant association between stress-related disease, major depression, and amount mtDNA (p = 9.00 × 10(-42), odds ratio 1.33 [95% confidence interval [CI] 1.29-1.37]) telomere length 2.84 10(-14), 0.85 CI...
The objective of our study was to compare the ablation zones two cooled-shaft microwave antennae-one operating at 915 MHz and one 2,450 MHz-in in vivo porcine livers.The 915-MHz antenna can lead deeper penetration liver tissue yield a significantly larger zone than 2,450-MHz livers. In light result, microwaves may be more effective for tumor ablation, especially large tumors.
Human respiratory syncytial virus (HRSV) is the predominant pathogen causing acute tract infection (ARTI). Globally, HRSV represents leading cause of morbidity and hospitalization in children under 2 years age. continues to pose a significant public health challenge worldwide. Through epidemiological surveillance with ARTI, we can elucidate its incidence patterns epidemic characteristics inform evidence-based prevention control strategies. We collected upper lower specimens clinical data...
Although several lines of evidences suggest that the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism may be involved in pathophysiology schizophrenia, this association remains controversial. Here, we aim to investigate genetic between BDNF and schizophrenia explore whether could influence severity clinical symptoms schizophrenic patients a Chinese Han population.Genotyping was carried out 456 483 controls using fluorescence resonance energy transfer method. The patients'...
Reducing energy consumption and promoting sustainable mobility solutions, including public transport (PT), are increasingly becoming key objectives for policymakers worldwide. Energy saving dispatching optimization bus rapid transit (BRT) is one of the most efficient strategies reducing traffic congestion conservation. The purpose this paper to address BRT problem while taking into account association between vehicle type, waiting time passengers vehicles. This presents a mechanical model...
The relationship between suicidality and major depression is complex. Socio- demography, clinical features, comorbidity, symptoms, stressful life events are important factors influencing suicide in depression, but these not well defined. Thus, the aim of present study was to assess associations above-mentioned ideation, plan, attempt 6008 Han Chinese women with recurrent (MD). Patients any had significantly more MD a greater number events, positive family history MD, episodes, significant...
Purpose: The incidence of nonsuicidal self-injury (NSSI) behavior among adolescents increases year by year. Patients with a history both depression and NSSI behaviors tend to have greater risk suicide. At present, the mechanism adolescent depressive disorder patients is not clear, epigenetic may be involved. Proopiomelanocortin ( POMC ) gene associated disorder. purpose this study was investigate DNA methylation promoter region behaviors. Methods: Bisulfite Sequencing PCR (BSP) used test...
The incidence of non-suicidal self-injury (NSSI) behavior in adolescents is increasing year by year. Patients with a history both depression and NSSI tend to be at greater risk for suicide. At present, the mechanism adolescent depressive disorder not clear still research exploration. expression Silent Information Regulator 2 Related Enzyme 1 (SIRT1) gene closely related level serotonin molecular mechanisms, may occurrence development disorder. This study aimed explore relationship between...
Abstract The diversity of products and fierce competition make the stability production cost manufacturing industry more important. So, purpose this paper is to deal with multi-product aggregate planning (APP) problem considering in workforce total costs, propose an efficient algorithm. Taking into account relationship raw materials, inventory product demand, a multi-objective programming model for APP established minimize costs instability work force. To improve efficiency algorithm,...
Abstract Analyzing of the energy consumption (EC) in bus operation is important for reducing operating costs, improving sustainable solutions and creating environmentally friendly cities. The purpose this paper to identify factors, such as passenger load, speed acceleration, that affect significantly EC operation. This builds a simulation framework describing level based on vehicle-engine combined (VEC) model. On basis relationship between engine torque, power, traction EC, mainly includes...
Abstract Background Schizophrenia is a complex psychiatric disorder with unknown etiology. A number of recent studies have shown that the polymorphism neural precursor cell expressed developmentally down-regulated 4 ( NEDD4 ) gene associated variety neuropsychiatric disorders, such as schizophrenia, and may also be cognitive dysfunction in these diseases. Methods case-control study was carried out, alleles genotypes distributions five loci (rs3088077, rs2303579, rs7162435, rs11550869,...
Abstract Background Recent studies have shown that the excitatory amino acid transporters (EAATs) are associated with schizophrenia. The aim of this study was to investigate relationship between polymorphism EAAT1 and EAAT2 genes schizophrenia in Chinese Han population. Methods A total 233 patients 342 healthy controls were enrolled. Two SNPs gene (rs2269272, rs2731880) four (rs12360706, rs3088168, rs12294045, rs10836387) genotyped by SNaPshot. Clinical features collected using a self-made...
The gene – environment (G × E) interaction effect is involved in severe mental disorders. However, whether the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism participates childhood-abuse influenced schizophrenic symptoms remains unclear. We examined between BDNF Val66Met, and childhood trauma (ChT) on psychotic a Chinese Han population. To estimate G E interaction, psychiatric interviews, self-report questionnaires for ChT, genotyping were carried out 201 patients....
Background Diagnostic information for psychiatric research often depends on both clinical interviews and medical records. Although discrepancies between these two sources are well known, there have been few studies into the degree origins of inconsistencies. Principal findings We compared data from structured records 1,970 Han Chinese women with recurrent DSM-IV major depression (MD). Correlations were high age at onset MD (0.93) number episodes (0.70), intermediate family history (+0.62)...
Due to the influence of insufficient production capacity or shortage materials, enterprises may produce products in advance be backordered. In order improve adaptability and reduce costs, impacts early delivery delayed are analyzed, method determine loss threshold is put forward. Moreover, maximum allowable customers with different tardiness calculated, cost sales determined. Considering cost, raw material inventory staff stockout, lost an early/delay multi-objective optimization model...
Purpose – Critical links in traffic networks are those who should be better protected because their removal has a significant impact on the whole network. So, purpose of this paper is to identify critical networks. Design/methodology/approach This proposes definition link for an urban network and establishes mathematical model determining considering travellers’ heterogeneous risk-taking behavior. Moreover, order improve computational efficiency, area quantified, partial scan algorithm...
To assess the association of neural precursor cell expressed developmentally down-regulated 4 (NEDD4) with schizophrenia.Five single nucleotide polymorphisms (SNPs) NEDD4 gene were genotyped by TaqMan SNP genotyping assay in an independent sample 464 individuals schizophrenia and 487 healthy controls from eastern Han Chinese population. Clinical data collected a general information questionnaire Positive Negative Syndrome Scale (PANSS).Frequencies rs3088077 (allelic: χ2=18.024, P=0.000;...
Background Dysthymia is a form of chronic mild depression that has complex relationship with major depressive disorder (MDD). Here we investigate the role environmental risk factors, including stressful life events and parenting style, in patients both MDD dysthymia. We ask whether these factors act same way without Results examined clinical features 5,950 Han Chinese women between 30–60 years age across China. confirmed earlier results by replicating prior analyses 3,950 new cases. There...
To assess the association between brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism and clinical characteristics of first episode schizophrenia in a Chinese Han population.Genotyping BDNF was carried out for 135 schizophrenic patients 483 healthy controls with TaqMan probe technology. The patients' psychotic symptoms were assessed using positive negative syndrome scale (PANSS).A significant difference found genotype distribution allelic frequency two groups (P< 0.01). In...