A5062471771- Antibiotics Pharmacokinetics and Efficacy
- Effects and risks of endocrine disrupting chemicals
- Gut microbiota and health
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Genomics, phytochemicals, and oxidative stress
- Drug Transport and Resistance Mechanisms
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Ultrasound Imaging and Elastography
- Cancer Diagnosis and Treatment
- Probiotics and Fermented Foods
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Natural Antidiabetic Agents Studies
- Cancer-related gene regulation
- Polysaccharides and Plant Cell Walls
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Diet, Metabolism, and Disease
- Breast Lesions and Carcinomas
- Barrier Structure and Function Studies
- Trigeminal Neuralgia and Treatments
Chinese Center For Disease Control and Prevention
2023-2024
National University of Singapore
2024
National University Health System
2024
University of Science and Technology of China
2024
Beijing University of Chinese Medicine
2022-2023
Hebei Agricultural University
2018-2022
Xiang Yang No.1 People's Hospital
2022
Zhejiang Shuren University
2022
Ministry of Education of the People's Republic of China
2022
Nanjing Medical University
2021-2022
Glioblastoma is the most destructive type of brain cancer. The blood–brain barrier (BBB) a tremendous obstacle that hinders therapeutic agents, such as chemical drugs and antibodies, from reaching glioblastoma tissues. Meanwhile, abnormal microenvironment extremely restricts expected effects accumulated drugs. Therefore, in present study, BBB-regulating nanovesicles (BRN) are developed to achieve targeted controlled BBB regulation, carrying adenosine 2A receptor (A2AR) agonists...
This study investigated the effects of Salvia miltiorrhiza polysaccharides (SMPs) on injury chicken hepatocytes in vitro and vivo. In studies primary cultured were isolated by 2-step collagenase perfusion. Carbon tetrachloride (CCL4) was added to establish a hepatocyte model. Hepatocytes treated with different concentrations SMPs detect protective CCL4-induced injury. The results control group showed that grew well their morphology normal. After CCL4 treatment, activity alanine transaminase...
This study aimed to investigate the structure characteristics Lonicera flos polysaccharides (LP) and protective effects of LP on cyclophosphamide-induced immunosuppression in mice. The results showed yield purity was 1.41% 94.15%, molecular weight 53 kDa, composed arabinose, rhamnose, ribose, xylose, mannose, fructose, galactose glucose; had typical polysaccharide structural via ultraviolet Fourier transform infrared (FTIR) spectroscopy, 1H NMR 13C spectra, scanning electron microscopy (SEM)...
Florfenicol (FFC) is a common antibiotic for animals. The nonstandard and excessive use of FFC can cause veterinary drug residues in animals, pollute soil marine environment, even threaten human health. Therefore, it necessary to study the toxicity side effects on Our previous studies have proved that liver injury chicks, but there are few in-depth mechanism causing at level signaling pathway chicks. transcriptome proteome sequencing were performed combined analysis was performed. Sequencing...
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of cirrhosis and cancer. Lonicerae flos polysaccharides (LPs) have been shown to be effective in treating metabolic diseases; however, therapeutic effects underlying molecular mechanisms LPs NAFLD remain unclear.The objective this study was investigate morphological characterization mechanism relieving NAFLD.The morphology observed using atomic force microscopy (AFM), X-ray diffraction (XRD), thermal weight (TG), derivative...
The pursuit of drugs and methods to safeguard dopaminergic neurons holds paramount importance in Parkinson’s disease (PD) research. Benfotiamine (BFT) has demonstrated neuroprotective properties, yet its precise mechanisms PD remain elusive. This study investigated BFT’s potential protective effects against dopamine neuron damage a animal model the underlying mechanisms. mouse was induced by 5 consecutive MPTP injections, followed BFT intervention for 28 days. Motor deficits were assessed...
This study investigated the anti-inflammatory effects and possible underlying mechanisms of Salvia miltiorrhiza polysaccharides (SMP) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The cytotoxicity SMP was detected by MTT method. morphological change observed Diff-Quik staining. Enzyme-linked immunosorbent assay used to evaluate production cytokines LPS-induced nitric oxide (NO) kit NO release from Real-time polymerase chain reaction detect transcriptions tumor necrosis factor-alpha...
Ulcerative colitis (UC) is a modern, refractory disease, and studies have shown that UC closely associated with the gut microbiota intestinal immune barrier. This study evaluated protective effects regulatory mechanism of Chinese dwarf cherry [Cerasus humilis (Bge.) Sok.] fermentation juice (CFJ) on induced by dextran sulfate sodium (DSS). The results indicated CFJ could significantly modulate oxidative stress index in serum colon, observably reduce MPO NO activity, increase SOD level....
In order to study the effects and mechanism of florfenicol (FFC) on kidney function broilers, 180 1-day-old broilers were randomly divided into 6 groups, 30 in each group. Except for control group, different doses FFC added drinking water other 5 groups (0.15 g/L, 0.3 0.6 1.2 g/L 1.8 g/L). After continuous administration days, renal histopathological changes, serum indicators, peroxidation products antioxidant factors, apoptotic factors detected aged 21 42 days. The results showed that...
Exposure to the emerging contaminant bisphenol A (BPA) is ubiquitous and associated with reproductive disorders.
To explore the effect of florfenicol (FFC) combined with Salvia miltiorrhiza polysaccharide (SMPs) on immune function Broilers. One hundred and twenty-one-day-old chicks were chosen divided into 6 groups. The group A received standard basal diet only, B a FFC (0.15 g/L diet), C, D, E diet) SMPs (1.25 g/L, 2.5 5 diet),the F (5 diet). can significantly inhibit growth performance broilers, but has no significant damage to broilers. combination improve increase number leukocyte subtypes in blood...
The study was conducted to investigate the protective effects of Salvia miltiorrhiza polysaccharides (SMPs) on lipopolysaccharides (LPS)/d-galactosamine (d-GalN)-induced liver injury in mice and its mechanism. Seventy-two were allocated 6 groups 12 each, that is, untreated control group, model Bifendate group (Bifendate 200 mg/kg/day), 3 SMP-treated at low (250 medium (500 high doses (750 mg/kg/day). After days oral treatment, induced with LPS/d-GalN, 1 h later sacrificed for a series...
Purpose: The incidence of nonsuicidal self-injury (NSSI) behavior among adolescents increases year by year. Patients with a history both depression and NSSI behaviors tend to have greater risk suicide. At present, the mechanism adolescent depressive disorder patients is not clear, epigenetic may be involved. Proopiomelanocortin ( POMC ) gene associated disorder. purpose this study was investigate DNA methylation promoter region behaviors. Methods: Bisulfite Sequencing PCR (BSP) used test...
The objective of this study was to determine the effects compound small peptides Chinese medicine (CSPCM) on intestinal microbiota broilers. A total thirty-six 1-day-old Arbor Acres broilers were assigned 6 dietary treatments that include 250, 500, and 750 g/T CSPCM in feed, 100 Bacillus subtilis Clostridium butyricum 50,000 IU xylanase feed. Each treatment had 2 replicates with cages (3 birds per cage). jejunal digesta samples collected from chickens at 42 d. Operational taxonomic unit...
Hyperlipidemia is regarded as a public health matter, and its effective prevention treatment are urgently required. However, the of hyperlipidemia still relatively scarce.Fermented Cerasus humilis fruit (FCHF) had higher total flavonoid, phenolic, procyanidin, organic free amino acid content, lower sugar than non-fermented C. (NFCHF). Both FCHF NFCHF significantly prevent putting on weight. Furthermore, administration ameliorated cholesterol over-accumulation. In addition, activated...
Pruni Semen, the seed of several unique Prunus plants, is a traditional purgative herbal material. To determine authentic sources 46 samples from four species were collected and analyzed. Ten compounds including multiflorin A (Mul A), notable purative compound, isolated identified by chemical separation nuclear magnetic resonance spectroscopy. Seventy-six communal components ultra-high performance liquid chromatography with linear ion trap-quadrupole Orbitrap mass spectrometry, acetyl...