A5053789268- Subterranean biodiversity and taxonomy
- Genetic Associations and Epidemiology
- Bone health and osteoporosis research
- RNA and protein synthesis mechanisms
- Marine Ecology and Invasive Species
- RNA modifications and cancer
- Ichthyology and Marine Biology
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Genomics and Chromatin Dynamics
- Aquatic Invertebrate Ecology and Behavior
- Bone Metabolism and Diseases
- Genetics and Neurodevelopmental Disorders
- Parasite Biology and Host Interactions
- Vitamin D Research Studies
- Cognitive Abilities and Testing
- Suicide and Self-Harm Studies
- Genetic Mapping and Diversity in Plants and Animals
- Treatment of Major Depression
- Estrogen and related hormone effects
- Genetic factors in colorectal cancer
- Marine Biology and Ecology Research
- Genetic Neurodegenerative Diseases
- Fish Biology and Ecology Studies
- Diabetes and associated disorders
Hong Kong Polytechnic University
2025
University of Maryland, College Park
2019-2024
Memorial Hermann–Texas Medical Center
2022
American University
2013-2020
King's College London
2007-2013
The University of Queensland
2012
Royal Brisbane and Women's Hospital
2012
AstraZeneca (United Kingdom)
2011
University of Hong Kong
2005-2009
St Thomas' Hospital
2005-2007
Objective The purpose of this study was to identify genetic variants underlying the considerable individual differences in response antidepressant treatment. authors performed a genome-wide association analysis improvement depression severity with two drugs. Method High-quality Illumina Human610-quad chip genotyping data were available for 706 unrelated participants European ancestry treated major escitalopram (N=394) or nortriptyline (N=312) over 12-week period Genome-Based Therapeutic...
Studies of major depression in twins and families have shown moderate to high heritability, but extensive molecular studies failed identify susceptibility genes convincingly. To detect genetic variants contributing depression, the authors performed a genome-wide association study using 1,636 cases ascertained U.K. 1,594 comparison subjects screened negative for psychiatric disorders.Cases were collected from 1) case-control recurrent (the Depression Case Control [DeCC] study; N=1346), 2) an...
Background Suicidal behaviour can be conceptualised as a continuum from suicidal ideation, to attempts completed suicide. In this study we identify genes contributing in the depression RADIANT. Methodology/Principal Findings A quantitative suicidality score was composed of two items SCAN interview. addition, 251 cases with history serious suicide were classified form discrete trait. The trait correlated younger onset and number episodes depression, but not gender. genome-wide association...
A widely accepted model for the evolution of cave animals posits colonization by surface ancestors followed acquisition adaptations over many generations. However, speed adaptation in some species suggests mechanisms operating shorter timescales. To address these mechanisms, we used Astyanax mexicanus, a teleost with ancestral morphs (surface fish, SF) and derived (cavefish, CF). We exposed SF to completely dark conditions identified numerous altered traits at both gene expression phenotypic...
Objective: The purpose of this study was to find loci for major depression via linkage analysis a large sibling pair sample. Method: authors conducted genome-wide 839 families consisting 971 affected pairs with severe recurrent depression, comprising waves I and II the Depression Network Study cohort. In addition examining status, analyses in full data set were performed using diagnoses restricted by impairment severity, association mapping hits case-control attempted. Results: identified...
Summary Bone mineral density (BMD), a risk factor for osteoporosis, is believed to be under genetic control. The effect of environmental factors and gender on the heritability BMD bone size ill‐defined. In this study, estimates ( h 2 ) were determined in 3,320 southern Chinese subjects from 1,019 families using variance components model. age, weight height‐adjusted was 0.63–0.71 females, 0.74–0.79 males; size, 0.44–0.64 females 0.32–0.86 males. Adjustment lifestyle including calcium...
<b>Background:</b> The <i>FOXC2</i> gene on 16q24 is mutated in lymphoedema distichiasis (LD), which varicose veins (VV) are a common feature. We hypothesised that this might be implicated the development of VV normal population, therefore, after performing classical twin study, we tested for linkage and association white women. also with haemorrhoids (H), as separate venous anomaly at same locus. <b>Methods:</b> A total 2060 complete female pairs aged 18–80 years from St Thomas' Adult UK...
Abstract Vestigial structures are key indicators of evolutionary descent, but the mechanisms underlying their development poorly understood. This study examines vestigial eye formation in teleost Astyanax mexicanus , which consists a sighted surface-dwelling morph and multiple populations blind cave morphs. Cavefish embryos initially develop eyes, they subsequently degenerate become embedded head. The mutated genes involved cavefish have not been characterized. Here we identify cystathionine...
Abstract Loss of DNA copy number at the short arm chromosome 3 is one most common genetic changes in human lung cancer, suggesting existence or more tumor suppressor genes (TSG) 3p. To identify frequently deleted regions and candidate TSGs within these regions, a recently developed single-nucleotide polymorphism (SNP)-mass spectrometry-genotyping (SMSG) technology was applied to investigate loss heterozygosity (LOH) 30 primary non–small-cell cancers. A total 386 SNP markers that spanned...
Abstract Genome‐wide studies in major depression have identified few replicated associations, potentially due to heterogeneity within the disorder. Several suggested that age at onset (AAO) can distinguish sub‐types of with specific heritable components. This paper investigates role AAO genetic susceptibility for using genome‐wide association data on 2,746 cases and 1,594 screened controls from RADIANT studies, replication performed 1,471 1,403 two Munich studies. Three methods were used...
Abstract Early detection is a key step for effective intervention of hepatocellular carcinoma (HCC), the lack sensitive and specific biomarkers major reason high rate HCC‐related mortality. This report described an integrated strategy by combining SELDI‐ProteinChip, sophisticated algorithm analysis, acetonitrile (ACN) pre‐treatment two‐dimensional electrophoresis (2DE)–peptide mass fingerprinting (PMF) techniques to identify serological markers prediction HBV‐related HCC. Proteomic profiling...
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of hospital- and community-associated infections. The formation adherent clusters cells known as biofilms an important virulence factor in MRSA pathogenesis. Previous studies showed that subminimal inhibitory (sub-MIC) concentrations methicillin induce biofilm the strain LAC. In this study we measured ability sub-MIC eight other β-lactam antibiotics six non-β-lactam to LAC biofilm. All antibiotics, but none induced...
Chromosome 3p was reported by previous studies as one of the regions showing strong evidence linkage with schizophrenia. We performed a fine-mapping association study 6-Mb high-LD and gene-rich region on in Southern Chinese sample 489 schizophrenia patients 519 controls to search for susceptibility genes. In initial screen, 4 SNPs out 144 tag genotyped were nominally significant (P < 0.05). One most (rs3732530, P = 0.0048) non-synonymous SNP neuroglycan C (NGC, also known CSPG5) gene, which...
Combining left ventricular assist device (LVAD) implantation and longitudinal sleeve gastrectomy may enable patients with morbid obesity to lose enough weight for heart transplant eligibility. In a retrospective study, we evaluated long-term outcomes of body mass indexes ≥35 who underwent LVAD during the same hospitalization (from January 2013 through July 2018) then adhered dietary protocol. We included 22 (mean age, 49.9 ± 12.5 yr; mean preoperative index, 43.3 6.2). Eighteen months after...