A5021932019- Gut microbiota and health
- Respiratory viral infections research
- Dietary Effects on Health
- Oral microbiology and periodontitis research
- Adipokines, Inflammation, and Metabolic Diseases
- Probiotics and Fermented Foods
- COVID-19 diagnosis using AI
- Diet and metabolism studies
- Mesenchymal stem cell research
- Natural Antidiabetic Agents Studies
- Genomics, phytochemicals, and oxidative stress
- Garlic and Onion Studies
- Cancer Cells and Metastasis
- Antimicrobial Peptides and Activities
- Phytochemicals and Antioxidant Activities
- Microbial Metabolites in Food Biotechnology
- Biochemical Analysis and Sensing Techniques
- Inflammatory Bowel Disease
- Adipose Tissue and Metabolism
- Extracellular vesicles in disease
- Cardiovascular Disease and Adiposity
- Polysaccharides Composition and Applications
- Infant Health and Development
- Gastroesophageal reflux and treatments
- IL-33, ST2, and ILC Pathways
Instituto de Investigación Biosanitaria de Granada
2018-2025
Universidad de Granada
2015-2025
Universitätsklinikum Erlangen
2025
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2021
Inflammatory bowel disease (IBD) is a chronic and idiopathic inflammatory disorder affecting the gastrointestinal tract. The pharmacological treatments used currently for its treatment lack efficacy, so new therapeutic strategies should be developed. In this context, flavonoids loaded in biopolymeric nanoparticles can considered as novel promising candidates. aim of present study was to evaluate intestinal anti-inflammatory effects quercetin when administered silk fibroin (QSFN) dextran...
Inflammatory bowel diseases, mainly ulcerative colitis and Crohn's disease are characterized by chronic inflammation in the intestine. Currently several therapeutic strategies available to treat inflammatory diseases. Though, most treatments can be associated with serious adverse effects what justifies search for new treatments. In this sense, we highlight interest herbal products rich bioactive compounds which immunomodulatory antioxidant properties as is case of Bryophyllum pinnatum...
Abstract Background The small GTPase RhoA controls cytoskeleton dynamics in various cell types, including intestinal epithelial cells (IECs). Accordingly, we have shown that lack of IECs mice increases permeability and inflammation1. However, its role cancer is controversial. While classically recognized as a potential colorectal (CRC) biomarker2, inactivation was found to increase Wnt signalling tumor risk mouse epithelium3. Additionally, proteins the RhoA/Rac1 pathway were identified...
Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by severe acute syndrome coronavirus 2 (SARS-CoV-2) that displays great variability in clinical phenotype. Many factors have been described to be correlated with its severity, and microbiota could play key role the infection, progression, outcome of disease. SARS-CoV-2 infection has associated nasopharyngeal gut dysbiosis higher abundance opportunistic pathogens. To identify new prognostic markers for disease, multicentre...
Immunomodulatory tetracyclines are well-characterized drugs with a pharmacological potential beyond their antibiotic properties. Specifically, minocycline and doxycycline have shown beneficial effects in experimental colitis, although pro-inflammatory actions also been described macrophages. Therefore, we aimed to characterize the mechanism behind effect acute intestinal inflammation.A comparative study was initially used elucidate most relevant of immunomodulatory tetracyclines:...
Increased levels of reactive oxygen species (ROS) and a low-grade chronic inflammation in multiple organs have been demonstrated obesity. Morus alba leaves extracts (MAEs) used traditional medicine as anti-inflammatory agents. In this work, the bioactive compounds different genotypes M. L. (Filipina, Valenciana Temprana, Kokuso, Italia) were analyzed not only by reverse phase high performance liquid chromatography–electrospray ionization-time flight-mass spectrometry (RP-HPLC-ESI-TOF-MS)...
Nowadays, there is an increasing interest in alternative therapies the treatment of metabolic syndrome that combine efficacy and safety profiles. Therefore, this study aimed to evaluate effect extract Thymus serpyllum, containing rosmarinic acid, on high-fat diet (HFD)-induced obesity mice, highlighting impact its antioxidant activity inflammatory status gut dysbiosis. The was administered daily (50, 100 150 mg/kg) HFD-fed mice. reduced body weight gain, glucose lipid Moreover, ameliorated...
Background: Propyl propane thiosulfonate (PTSO) is an organosulfur compound from Allium spp. that has shown interesting antimicrobial properties and immunomodulatory effects in different experimental models. In this sense, our aim was to evaluate its effect on model of obesity, focusing inflammatory metabolic markers the gut microbiota. Methods results: Mice were fed a high-fat diet orally treated with doses PTSO (0.1, 0.5 1 mg/kg/day) for 5 weeks. lessened weight gain improved plasma...
Patients with inflammatory bowel disease (IBD) have a higher risk of developing colitis-associated colorectal cancer (CAC) poor prognosis. IBD etiology remains undefined but involves environmental factors, genetic predisposition, microbiota imbalance (dysbiosis) and mucosal immune defects. Mesenchymal stromal cell (MSC) injections shown good efficacy in reducing intestinal inflammation animal human studies. However, their effect on tumor growth CAC capacity to restore gut dysbiosis are not...
Scope Obesity is characterized by a dysfunction in the adipose tissue and an inflammatory subclinical state leading to insulin resistance increased risk of cardiovascular diseases. It also associated with intestinal dysbiosis that contributes inflammation development. Lippia citriodora (LCE) contains high levels polyphenolpropanoids has shown promising results obesity. The aim this study investigate well‐characterized extract LCE model metabolic syndrome mice, focusing on its effects...
Obesity is a worldwide public health problem whose prevalence rate has increased steadily over the last few years. Therefore, it urgent to improve management of obesity and its comorbidities, plant-based treatments are receiving increasing attention worldwide. In this regard, present study aimed investigate well-characterized extract Lavandula multifida (LME) in an experimental model mice explore underlying mechanisms. Interestingly, daily administration LME reduced weight gain as well...
Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders characterized by relapsing intestinal inflammation, but many details of pathogenesis remain to be fully unraveled. Glucocorticoid (GC)-induced leucine zipper (GILZ) is a mediator the anti-inflammatory effects GCs, most powerful drugs for IBD treatment, they cause several unwanted side effects. The fusion protein TAT-GILZ has been successfully used in some pre-clinical models and autoimmune diseases. To test efficacy...
and Purpose: Colorectal cancer (CRC) is one of the cancers with highest incidence in which APC gene mutations occur almost 80% patients. This mutation leads to β-catenin aberrant accumulation an uncontrolled proliferation. Apoptosis evasion, changes immune response microbiota composition are also events that arise CRC. Tetracyclines drugs proven antibiotic immunomodulatory properties have shown cytotoxic activity against different tumor cell lines.The effect tigecycline was evaluated vitro...
Melatonin has shown beneficial effects on obesity, both in humans and experimental models, via regulating the altered circadian rhythm thus ameliorating gut dysbiosis associated with this metabolic condition. However, its clinical use is limited, mostly due to short half-life. Agomelatine an agonist of melatonin receptors that could be used manage obesity offer a better profile than melatonin.Male C57BL/6 mice were fed high fat diet orally treated for five weeks agomelatine, or metformin, as...
ABSTRACT Coronavirus disease 2019 (COVID-19) is a respiratory illness caused by severe acute syndrome coronavirus 2 (SARS-CoV-2) that displays great variability in clinical phenotype. Many factors have been described to be correlated with its severity, and microbiota could play key role the infection, progression, outcome of disease. SARS-CoV-2 infection has associated nasopharyngeal gut dysbiosis higher abundance opportunistic pathogens. To identify new prognostic markers for disease,...
Scope Capsicum annuum L. cv Senise is a sweet pepper containing health promoting compounds that can be modified by ripening and drying. This study focuses on finding the peppers with best antioxidant properties, which are evaluated an experimental model of obesity. Methods Results Phytochemical profile activity several obtained from same cultivar at different stages. Red show highest content in polyphenols, β‐carotene, lycopene, capsinoids, demonstrate vitro. Mice fed high fat diet orally...
Abstract Aim Disruption of the intestinal mucosal tolerance, that is, immunological unresponsiveness to innocuous food antigens and commensal microbiota, in colon is associated with several chronic diseases including inflammatory bowel disease (IBD). Understanding mechanisms responsible for tolerance has potential translational value its therapy management. Human mesenchymal cells (iMCs) play important roles colonic but further studies on their tissue regenerative immunomodulatory capacities...
Obesity is a global health issue, in which modifications gut microbiota composition have key role. Different therapeutic strategies are being developed combination with diet and exercise, including the use of plant extracts, such as those obtained from Morus alba L. leaves. Recent studies revealed their anti-inflammatory antioxidant properties. The aim present work was to evaluate whether beneficial effects M. leaf extract high-fat diet-induced obesity mice correlated its impact on...
The present work is focused on the development of an analytical platform to elucidate metabolic pathway PTSO from onion, organosulfur compound well-known for its functional and technological properties potential application in animal human nutrition. This consisted use gas chromatography-mass spectrometry (GC-MS) ultra-high performance liquid chromatography quadrupole with time-of-flight MS (UHPLC-Q-TOF-MS) order monitor volatile non-volatile compounds derived PTSO. For extraction interest,...