A5077138282- Systemic Sclerosis and Related Diseases
- Dermatologic Treatments and Research
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Inflammatory Myopathies and Dermatomyositis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Chronic Lymphocytic Leukemia Research
- Hemophilia Treatment and Research
- Mast cells and histamine
- Lymphoma Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- IgG4-Related and Inflammatory Diseases
- Body Image and Dysmorphia Studies
- Chronic Disease Management Strategies
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cutaneous lymphoproliferative disorders research
- Empathy and Medical Education
- Lipid metabolism and disorders
- Skin Diseases and Diabetes
- Genomics and Rare Diseases
- Dermatological and COVID-19 studies
- Protein Degradation and Inhibitors
Université de Lille
2019-2025
Lille Inflammation Research International Center
2018-2025
Inserm
2018-2025
Centre Hospitalier Universitaire de Lille
2017-2024
Université Lille Nord de France
2020-2024
Institute for Translational Research in Inflammation
2020-2024
Hôpital Claude Huriez
2015-2024
Centre Oscar Lambret
2022-2023
Targeting both interferon and complement pathways demonstrates significant efficacy to treat malignant atrophic papulosis, offering a potential groundbreaking therapeutic avenue for this rare life-threatening disease.
(1) Background: Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with high mortality and morbidity rate. Identification of biomarkers that can predict the evolution SSc key factor in management patients. The aim this study was to assess association routine laboratory parameters, widely used practice easily available, severity progression SSc. (2) Methods: In retrospective monocentric cohort study, 372 patients were included. We gathered clinical data including...
Patients with X linked agammaglobulinemia are susceptible to enterovirus (EV) infections. Similarly, severe EV infections have been described in patients impaired B-cell response following treatment anti-CD20 monoclonal antibodies (mAbs), mostly those treated for haematological malignancies. We aimed describe receiving mAbs immune-mediated inflammatory diseases (IMIDs).
Although dyslipidemia is a strong risk factor for thrombosis in antiphospholipid syndrome (APS), it has been poorly studied. This study aimed to assess lipids profile and factors unachieved cholesterol levels real-life APS population.Inclusion criteria were: diagnosis according international classification criteria, referring the out-patients clinic of our tertiary care center their follow-up, having blood sample collection determination. Cholesterol level targets each patient were defined...
Background: Systemic sclerosis is a fibrotic disease. Body image assessments could be key in optimizing care; however, data are scarce. The main objective was to assess the perception of aesthetic impairment using visual evaluation scale patients with systemic compared healthy subjects. secondary objectives were associations between and scores on standardized questionnaires for as well clinical, psychological/quality life, functional parameters sclerosis. Methods: This study evaluated two...
Abstract Systemic sclerosis (SSc) is the most severe systemic autoimmune disease with currently no cure. Intravenous immunoglobulins (IVIg) are an attractive candidate in this to counteract inflammation and fibrosis but data scarce conflicting. This study, assessed effects of IVIg a murine HOCl-induced model SSc. We showed that prevented skin fibrosis, by mitigating immune cell infiltration ( p = 0.04), proinflammatory cytokines gene overexpression (IL1β, 0.04; TNFα, IL6, 0.05), dermal...
Objective The European Reference Network on Rare and Complex Connective Tissue Musculoskeletal Diseases involves health care providers (HCPs) from 8 countries 7 patients’ representatives of Patient Advocacy Groups. objective was to evaluate current practice unmet needs for patient education (PE) in Europe. Methods A questionnaire sent HCP members asking about the PE practices another, enquire their needs, associations different countries. Results completed by 33 HCPs. Half had no specific...
Introduction: Differential diagnosis between angiotensin converting enzyme inhibitors (ACEi) angioedema (AE) and idiopathic histaminergic AE (ihAE) is often challenging. Follow-up data may help discriminate these conditions but are scarcely reported. Our objective was to report on the follow-up of patients with suspected ACEi-AE describe baseline characteristics attacks in a confirmed by follow-up. Methods: Sixty-four (i.e. exposure ACEi before first attack, no urticaria associated normal...
Objective: To optimise the organisation of care and encourage adoption good clinical practices, RarERN Path © methodology was designed within ERN ReCONNET. The aim our work to report application on systemic sclerosis ReCONNET centres, providing a feasible flexible organisational reference model for optimising pathway in different countries. Methods: is six-phase which enables creation co-designed basis expertise stakeholders. It foresees six phases, ranging from map existing patients’...
Background: A differential diagnosis between angiotensin-converting enzyme inhibitor (ACEi) angioedema (AE) and histaminergic AE (hAE) might be challenging. Follow-up data may help discriminate these conditions but are scarcely reported. Objective: To report on the follow-up of patients with suspected ACEi-AE to describe baseline characteristics attacks in a after follow-up. Methods: Sixty-four (i.e., exposure ACEi before first attack, no urticaria associated, normal C1-inhibitor levels) at...
Here we present the case of an hepato-splenic-Tγδ-cell lymphoma interestingly occurring in a non-immunocompromised patient, with profuse telangiectasias giving originally misleading orientation towards diagnosis B angiotropic lymphoma.
Introduction: Rare disease referral centres are entrusted with missions of clinical expertise and research, two activities that have to contend numerous obstacles. Providing specialist opinions is time-consuming, uncompensated limited by difficulties in exchanging medical data. Clinical research constrained the need for frequent protocol visits. Our objective was determine whether telemedicine (TLM) can overcome these difficulties. Methods: To better characterise activity provided our French...