A5042957305- Cutaneous Melanoma Detection and Management
- Digital Imaging in Medicine
- Cutaneous lymphoproliferative disorders research
- Autoimmune Bullous Skin Diseases
- Family and Patient Care in Intensive Care Units
- Emergency and Acute Care Studies
- Nonmelanoma Skin Cancer Studies
- Medicine and Dermatology Studies History
- HER2/EGFR in Cancer Research
- Maternal and fetal healthcare
- Neuroscience of respiration and sleep
- Healthcare Decision-Making and Restraints
- AI in cancer detection
- Infant Development and Preterm Care
- Dermatological diseases and infestations
- Monoclonal and Polyclonal Antibodies Research
- Prenatal Substance Exposure Effects
- Peptidase Inhibition and Analysis
- Urticaria and Related Conditions
- Primary Care and Health Outcomes
- Cancer Immunotherapy and Biomarkers
- Social Media in Health Education
- Maternal and Perinatal Health Interventions
- Health Policy Implementation Science
- Electronic Health Records Systems
Memorial Sloan Kettering Cancer Center
2011-2024
Pennsylvania Hospital
2019-2024
Access to Wholistic and Productive Living Institute
2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2024
Research Network (United States)
2024
National Institutes of Health
2024
Hospital of the University of Pennsylvania
2024
University of Pennsylvania
2023
Improvement Service
2023
Cornell University
2016-2021
Monoclonal antibodies (mAb) targeting immune checkpoint pathways such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed death 1 (PD-1) may confer durable disease control in several malignancies. In some patients, mAbs cause cutaneous immune-related adverse events. Although the most commonly reported toxicities are mild, a subset persist despite therapy can lead to severe or life-threatening toxicity. Autoimmune blistering disorders not associated with mAb therapy. We...
The use of artificial intelligence (AI) has the potential to improve assessment lesions suspicious melanoma, but few clinical studies have been conducted. We validated accuracy an open-source, non-commercial AI algorithm for melanoma diagnosis and assessed its impact on dermatologist decision-making. conducted a prospective, observational study assess diagnostic (ADAE) in predicting from dermoscopy skin lesion images. primary aim was reliability ADAE's sensitivity at predefined threshold...
Immune checkpoint inhibitors (ICI) target the PD-1/PD-L1 and CTLA-4 pathways allows immune system to deliver antitumor effects. However, it is also associated with well-documented immune-related cutaneous adverse events (ircAEs), affecting up 70–90% of patients on ICI. In this study, we describe characteristics patient outcomes ICI-associated steroid-refractory or steroid-dependent ircAEs treated dupilumab. Patients dupilumab between March 28, 2017, October 1, 2021, at Memorial Sloan...
<h3>Background:</h3> Melanoma incidence and mortality is a growing concern. Better recognition management of skin cancer by primary care providers (PCPs) could help, but studies suggest they would benefit from additional education. Effective educational programs are needed. <h3>Methods:</h3> We developed conducted voluntary before-and-after evaluation 1- to 2-hour interactive, web-based course in detection for practicing, board-certified PCPs...
Immunoglobulin E (IgE) blockade with omalizumab has demonstrated clinical benefit in pruritus-associated dermatoses (e.g. atopic dermatitis, bullous pemphigoid, urticaria). In oncology, cutaneous adverse events (paCAEs) are frequent immune checkpoint inhibitors (CPIs) and targeted anti-human epidermal growth factor receptor 2 (HER2) therapies. Thus, we sought to evaluate the efficacy safety of IgE cancer patients refractory paCAEs related CPIs anti-HER2 agents.Patients included this...
Dermoscopy is commonly used for the evaluation of pigmented lesions, but agreement between experts identification dermoscopic structures known to be relatively poor. Expert labeling medical data a bottleneck in development machine learning (ML) tools, and crowdsourcing has been demonstrated as cost- time-efficient method annotation images.The aim this study demonstrate that can label basic from images lesions with similar reliability group experts.First, we obtained labels 248 melanocytic 31...
Dermoscopy aids in clinical decision-making. However, time pressure is a common reason precluding its use. We evaluated the effect of on lesion recognition and management decisions utilising dermoscopic images.In all, 100 images were presented to 15 dermatologists with experience dermoscopy seven non-experts (dermatology residents). Each was displayed thrice succession. The image initially for 1 s (t1). same shown again without constraints (t2) then final additional context (t3)....
To the Editor: Despite widespread use of photography, data on patient attitudes towards photography is scarce1Leger M.C. Wu T. Haimovic A. et al.Patient perspectives medical in dermatology.Dermatol Surg. 2014; 40: 1028-1037https://doi.org/10.1097/01.DSS.0000452632.22081.79Crossref PubMed Scopus (40) Google Scholar and practices regarding photographs, consent guidelines, or deidentification are not standardized.2Harting M.T. DeWees J.M. Vela K.M. Khirallah R.T. Medical photography: current...
Background: Escalating and aggressive visitor behaviors have become increasingly common in healthcare settings nationally, negatively impacting staff patients alike. Most providers do not innately possess the specific skills to manage such behaviors. Management of escalating presents a particularly bedeviling challenge when safety must be balanced with needs parent–neonate bonding. Purpose: In Intensive Care Nursery (ICN), frequency hostile incidents from visitors increased that felt...
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Background: Postpartum hemorrhage (PPH) is a leading cause of maternity mortality in the United States. The Code Crimson project aimed to enhance PPH management by implementing standardized intervention bundle mitigate morbidity and associated with PPH. Local Problem: At large Philadelphia tertiary hospital, health disparities existed for severe maternal mortality, was significant factor. Methods: A quality improvement design, using Plan-Do-Study-Act cycles interrupted time series analysis,...
Researchers in obstetrics and gynecology are continuously generating new evidence to inform clinical care delivery. Yet, much of this newly emerging fails be rapidly effectively integrated into routine practice. Implementation climate refers clinicians' perceptions what degree organizations support reward use an evidence-based practice (EBP) is important construct the science implementation healthcare. Little known about for EBPs maternity care. Thus, we aimed (a) determine reliability...
Abstract Purpose The combination of trastuzumab and pertuzumab (HP) as part a taxane-based regimen has shown benefit in the adjuvant metastatic HER2 + breast cancer setting. In CLEOPATRA trial, pruritus was reported 11-17.6% patients. clinical phenotype potential treatment strategies for this event have not been reported. Methods A retrospective review 2583 patients receiving from 11/23/2011 to 6/21/2021 performed at Memorial Sloan Kettering Cancer Center (MSKCC). Patient demographics,...
Abstract Purpose The combination of trastuzumab and pertuzumab (HP) as part a taxane-based regimen has shown benefit in the adjuvant metastatic HER2+ breast cancer setting. In CLEOPATRA trial, pruritus was reported 11-17.6% patients. clinical phenotype potential treatment strategies for this event have not been reported. Methods A retrospective review 2583 patients receiving from 11/23/2011 to 6/21/2021 performed at Memorial Sloan Kettering Cancer Center (MSKCC). Patient demographics,...