Jennifer Villa
A5065459042- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Bacterial biofilms and quorum sensing
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- Antimicrobial Resistance in Staphylococcus
- Infections and bacterial resistance
- Streptococcal Infections and Treatments
- Vibrio bacteria research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Enterobacteriaceae and Cronobacter Research
- Viral gastroenteritis research and epidemiology
- Genomics and Phylogenetic Studies
- SARS-CoV-2 detection and testing
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Infective Endocarditis Diagnosis and Management
- Nosocomial Infections in ICU
- SARS-CoV-2 and COVID-19 Research
- Clostridium difficile and Clostridium perfringens research
- Lipoproteins and Cardiovascular Health
- Diet and metabolism studies
- BRCA gene mutations in cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
Hospital Universitario 12 De Octubre
2013-2024
Research Institute Hospital 12 de Octubre
2016-2024
Universidad Complutense de Madrid
2024
European Institute of Oncology
2023
Centro de Ornitología y Biodiversidad
2012
Hospital Universitario Son Espases
2012
University of Vermont
2010-2011
To undertake a Spanish nationwide survey on Pseudomonas aeruginosa molecular epidemiology and antimicrobial resistance. Up to 30 consecutive healthcare-associated P. isolates collected in 2017 from each of 51 hospitals were studied. MICs 13 antipseudomonal agents determined by broth microdilution. Horizontally acquired β-lactamases detected phenotypic methods PCR. Clonal was evaluated through PFGE MLST; at least one XDR isolate clone hospital (n = 185) sequenced. The most active...
Whether multidrug resistance (MDR) is associated with mortality in patients Pseudomonas aeruginosa bloodstream infections (BSI) remains controversial. Here, we explored the prognostic factors of P. BSI emphasis on antimicrobial and virulence. All episodes a 5-year period were retrospectively analyzed. The impact early (5-day) late (30-day) crude host, antibiotic treatment, pathogen was assessed by multivariate logistic regression analysis. Of 243 episodes, 93 (38.3%) caused MDR-PA. Crude...
Imipenem and imipenem-relebactam MICs were determined for 1,445 Pseudomonas aeruginosa clinical isolates a large panel of isogenic mutants showing the most relevant mutation-driven β-lactam resistance mechanisms. Imipenem-relebactam showed highest susceptibility rate (97.3%), followed by colistin ceftolozane-tazobactam (both 94.6%).
Abstract A total of 183 patients were colonized or infected with multidrug-resistant Pseudomonas aeruginosa isolates at a hospital in Spain during 2007–2010; prevalence increased over this period from 2.8% to 15.3%. To characterize these isolates, we performed molecular epidemiologic and drug resistance analysis. Genotyping showed that 104 (56.8%) belonged single major clone (clone B), which was identified by multilocus sequence typing as type (ST) 175. This initially isolated 5 2008, then...
Antibiotic resistance is an emerging phenomenon in kidney transplantation (KT).We compared species distribution and antimicrobial susceptibility patterns 1052 isolates from urine cultures obtained 2 different cohorts of transplant recipients a single center (Cohort A: 189 patients undergoing KT between January 2002 December 2004 [336 isolates]; Cohort B: 115 2011 2013 [716 isolates]).Asymptomatic bacteriuria accounted for most the (86.9% A 92.3% B). Klebsiella pneumoniae (9.5% vs. 15.6%),...
We describe the clonal spread of New Delhi metallo-β-lactamase (NDM) 1-producing
Most Staphylococcus aureus small-colony variants (SCVs) are auxotrophs for menadione, hemin, or thymidine but rarely CO(2). We conducted a prospective investigation of all clinical cases CO(2)-dependent S. during 3-year period. found 14 isolates from patients that fulfilled requirements to be considered SCVs, 9 which were methicillin resistant. The presentations included four catheter-related bacteremia, one complicated by endocarditis; two deep infections (mediastinitis and...
The objective of the present study was to evaluate value PCR cycle threshold (CT ) for predicting recurrence/severity infection compared that toxin detection plus clinical variables. First episodes Clostridium difficile (CDI) diagnosed during 2015 at our institution were included. Samples tested glutamate dehydrogenase (GDH) and A/B by use a single enzyme immunoassay (EIA). Xpert C. assay performed on GDH-positive samples. Medical data reviewed investigators blinded diagnostic results...
Abstract Objectives To evaluate the correlation of O-antigen serotypes with resistance profiles and high-risk clones in a Spanish nationwide survey. Methods Up to 30 consecutive healthcare-associated Pseudomonas aeruginosa isolates were collected during October 2017 from each 51 hospitals (covering all regions) total 1445 studied. MICs 13 antipseudomonal agents MDR/XDR had been previously determined, as well whole-genome sequences 185 representative XDR isolates. (O1–O16) determined by...
Abstract Background Community-acquired (CA) and healthcare-associated (HCA) infections caused by carbapenemase-producing Enterobacterales (CPE) are not well characterized. The objective was to provide detailed information about the clinical molecular epidemiological features of nosocomial, HCA CA Klebsiella pneumoniae (CP-Kp) Escherichia coli (CP-Ec). Methods A prospective cohort study performed in 59 Spanish hospitals from February March 2019, including first 10 consecutive patients whom...
The emergence of ceftazidime/avibactam (CZA) resistance among Guiana extended-spectrum β-lactamase (GES)-producing Pseudomonas aeruginosa isolates has rarely been described. Herein, we analyze the phenotypic and genomic characterization CZA in different GES-producing P. that emerged our institution. A subset nine CZA-resistant was analyzed compared with thirteen CZA-susceptible by whole-genome sequencing (WGS). All belonged to ST235 clone O11 serotype. variety GES enzymes were detected:...
The ability of Staphylococcus aureus to invade tissues and cause an infectious disease is the result a multi-factorial process supported by huge number virulence factors inherent this microorganism tightly regulated accessory gene regulator (agr). During antimicrobial therapy bacteria may be exposed sub-inhibitory concentrations (subMICs) antibiotics that trigger transcriptional changes have impact on pathogenesis infection. objective study was investigate effect oxacillin sub-MICs agr...