A5082656914- Antifungal resistance and susceptibility
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Pneumocystis jirovecii pneumonia detection and treatment
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Fungal Infections and Studies
- Renal Transplantation Outcomes and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Herpesvirus Infections and Treatments
- Influenza Virus Research Studies
- Respiratory viral infections research
- Antibiotic Resistance in Bacteria
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Polyomavirus and related diseases
- Bacterial biofilms and quorum sensing
- Pneumonia and Respiratory Infections
- Plant Pathogens and Fungal Diseases
- Central Venous Catheters and Hemodialysis
- Mycobacterium research and diagnosis
- Nosocomial Infections in ICU
- Streptococcal Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Neurological Complications and Syndromes
Vall d'Hebron Institut de Recerca
2014-2024
Vall d'Hebron Hospital Universitari
2013-2024
Centro de Investigación Biomédica en Red
2022-2024
Instituto de Salud Carlos III
2014-2024
Red Espanola de Investigacion en Patologia Infecciosa
2012-2023
Universitat Autònoma de Barcelona
2010-2022
Universidad de Navarra
2017
Hebron University
2009-2017
GTx (United States)
2013
In-Q-Tel
2013
Background. The aim of this study was to compare the effectiveness ampicillin plus ceftriaxone (AC) and gentamicin (AG) combinations for treating Enterococcus faecalis infective endocarditis (EFIE). Methods. An observational, nonrandomized, comparative multicenter cohort conducted at 17 Spanish 1 Italian hospitals. Consecutive adult patients diagnosed EFIE were included. Outcome measurements death during treatment 3 months follow-up, adverse events requiring withdrawal, failure a change...
Background. It is necessary to clarify the incidence of and risk factors for tuberculosis (TB) among solid-organ transplant (SOT) recipients as well changes in chronology, clinical presentation, prognosis disease. Methods. A total 4388 SOT were monitored prospectively at 16 centers included Spanish Network Research Infectious Diseases (REIPI). TB episodes studied, rate was calculated. Certain variables analyzed, by Cox regression analysis, potential TB. Results. Among recipients, 21 cases...
To facilitate the design of strategies for prevention invasive aspergillosis in solid-organ transplant recipients, this study investigates whether development early-onset and late-onset are related to different risk factors, thereby distinguishing 2 populations serious complication.A retrospective case-control was performed, including 156 cases proven or probable patients recruited from 11 Spanish centers since start centers' transplantation programs.Among all patients, 57% had IA (i.e.,...
Bloodstream infections (BSIs) are a major cause of morbidity and mortality in transplant recipients. The aim this study is to describe the incidence, microbiology outcomes BSIs recipients Spain. Spanish Network for Research on Infection Transplantation (RESITRA) formed by 16 centers with program incidence characteristics patients were obtained prospectively from cohort. We included 3926 (2935 solid organ 991 hematopoietic stem cell transplants). Overall, 730 episodes recorded an rate ranging...
Background: High-level aminoglycoside resistance (HLAR) that precludes bactericidal synergism with penicillins or glycopeptides and nephrotoxicity related to treatment are major problems in treating Enterococcus faecalis endocarditis. Objective: To evaluate the efficacy safety of ampicillin plus ceftriaxone for endocarditis due E. without HLAR. Design: Observational, open-label, nonrandomized, multicenter clinical trial. Setting: 13 centers Spain. Patients: 21 patients HLAR 22 non-HLAR All...
Seasonal influenza infection may cause significant morbidity and mortality in transplant recipients. The purpose of this study was to assess the epidemiology symptomatic posttransplant determine risk factors for severe disease.Twenty centers United States, Canada, Spain prospectively enrolled solid organ (SOT) or hematopoietic stem cell (HSCT) recipients with microbiologically confirmed influenza over 5 consecutive years (2010-2015). Demographics, microbiology data, outcomes were collected....
Since 2005, 11 human face transplants have been performed. In each, varying amounts of tissue transplanted. Herein we report a "full" transplant including all intact aesthetic and functional units.On March 27, 2010, performed full transplant, the soft tissues part underlaying bony structure, at University Hospital Vall d'Hebron, Barcelona, Spain. The donor was 41-year-old male, who died from massive brain hemorrhage. recipient 30-year-old male with severe facial deformity caused by ballistic...
Solid-organ transplant (SOT) recipients are classically considered to be at increased risk for listeriosis. However, factors this infection have not been assessed.We carried out a multicenter, matched case-control study (1:2 ratio) from January 1995 through December 2007. Control subjects were center, type, and timing. Conditional logistic regression was performed identify independent factors. Clinical features outcomes all case patients reviewed.Thirty (0.12%) with cases of listeriosis...
Influenza vaccine effectiveness is not optimal in solid organ transplant recipients (SOTR). We hypothesized that a booster dose might increase it.TRANSGRIPE 1-2 phase 3, randomized, controlled, multicenter, open-label clinical trial. Patients were randomly assigned (1:1 stratified by study site, type of organ, and time since transplantation) to receive 1 (control group) or 2 doses (booster the influenza 5 weeks apart.A total 499 SOTR enrolled. Although seroconversion at 10 did meet...
This study describes the clinical presentation, treatment, and outcomes of SARS-CoV-2 infection in lung transplant recipients (LTRs). is a multicenter, retrospective all adult LTRs with confirmed from March 4 until April 28, 2020 six Spanish reference hospitals for transplantation. Clinical radiological data, treatment characteristics, were reviewed. Forty-four cases identified that period. The median time transplantation was 4.2 (interquartile range: 1.11-7.3) years. Chest radiography...
The purpose of this study was to evaluate the incidence and etiology bacterial fungal infection or contamination in lung allograft donors assess donor-to-host transmission these infections. Recipients who survived more than 24 h their respective were evaluated. overall donor 52% (103 out 197 donors). Types included isolated preservation fluids (n = 30, 29.1%), graft colonization 65, 63.1%) bacteremia 8, 7.8%). Donor-to-host occurred 15 recipients, 7.6% transplants performed. Among cases, 2...
Background. Current advances in transplantation practices may influence the development of cytomegalovirus (CMV) disease after renal transplantation. Methods. From September 2003 through February 2005, 1470 transplant recipients (55 whom were kidney-pancreas recipients) prospectively studied 16 centers affiliated with Spanish Network Infection Transplantation, use an ad hoc–designed online database. Univariate and multivariate analyses logistic regression performed to detect risk factors for...
Information describing the incidence and clinical char-acteristics of late infection (LI) in solid organ transplan-tation (SOT) is scarce. The aim this study was to define incidence, characteristics risk factors for LI (>6 months) as compared with early period (<6 after SOT. By on-line database Spanish Network Infection Transplantation (RESITRA) we prospectively analyzed 2702 SOT recipients from September 2003 February 2005. Univariate multivariate analysis using logis-tic regression were...
Surgical site infections are common bacterial in orthotopic liver transplantation. The purpose of this study was to determine the incidence, timing, location, and risk factors, specifically antibiotic prophylaxis, for surgical infections. A prospective performed that included a population 1222 consecutive patients (73.0% males) who underwent transplantation Spanish hospitals belonging Red de Estudio la Infección en el Trasplante research network. One hundred seven developed predominant...
Objective. The aim of this prospective, multicenter, noncomparative, open-label trial was to evaluate the prophylactic use caspofungin in adult liver transplant recipients at high risk developing invasive fungal infections (IFI). Methods. Patients received for least 21 days. A successful treatment outcome defined as absence breakthrough IFI during first 100 days after onset caspofungin. Results. According study design, 71 patients were included. In modified intention-to-treat analysis,...
The epidemiology of respiratory viruses (RVs) in lung transplant recipients (LTRs) and the relationship RVs to function, acute rejection (AR) opportunistic infections these patients are not well known. We performed a prospective cohort study (2009–2014) by collecting nasopharyngeal swabs (NPSs) from asymptomatic LTRs during seasonal changes with upper tract infectious disease (URTID), lower (LRTID) AR. NPSs were analyzed multiplex polymerase chain reaction. Overall, 1094 collected 98 23.6%...