A5061006700- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Plant nutrient uptake and metabolism
- Influenza Virus Research Studies
- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Mesenchymal stem cell research
- Hepatitis C virus research
- Respiratory viral infections research
- Health Systems, Economic Evaluations, Quality of Life
- Sex and Gender in Healthcare
- Animal Virus Infections Studies
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Organ and Tissue Transplantation Research
- Mass Spectrometry Techniques and Applications
- Advanced Causal Inference Techniques
- Childhood Cancer Survivors' Quality of Life
- Radiopharmaceutical Chemistry and Applications
- Economic and Financial Impacts of Cancer
- Virus-based gene therapy research
- Plant tissue culture and regeneration
- Pharmaceutical studies and practices
- Breast Cancer Treatment Studies
Junta de Andalucía
2017-2023
Fundació ACE
2021
Instituto de Biomedicina de Sevilla
2014-2017
Universidad de Sevilla
2017
Andalusian Agency for Healthcare Quality
2017
Hospital Universitario Virgen del Rocío
2004-2016
Instituto Maimónides de Investigación Biomédica de Córdoba
2015
Consejo Superior de Investigaciones Científicas
2006-2011
Instituto de Recursos Naturales y Agrobiología de Sevilla
2011
University of York
2007
Abstract The salt tolerance of rice (Oryza sativa) correlates with the ability to exclude Na+ from shoot and maintain a low cellular Na+/K+ ratio. We have identified plasma membrane Na+/H+ exchanger that, on basis genetic biochemical criteria, is functional homolog Arabidopsis (Arabidopsis thaliana) overly sensitive 1 (SOS1) protein. transporter, denoted by OsSOS1, demonstrated capacity for exchange in vesicles yeast (Saccharomyces cerevisiae) cells reduced their net content. protein kinase...
The plasma membrane sodium/proton exchanger Salt-Overly-Sensitive 1 (SOS1) is a critical salt tolerance determinant in plants. SOS2–SOS3 calcium-dependent protein kinase complex up-regulates SOS1 activity, but the mechanistic details of this crucial event remain unresolved. Here we show that maintained resting state by C-terminal auto-inhibitory domain target SOS2–SOS3. interacts intramolecularly with an adjacent essential for activity. relieved from auto-inhibition upon phosphorylation...
Influenza vaccine effectiveness is not optimal in solid organ transplant recipients (SOTR). We hypothesized that a booster dose might increase it.TRANSGRIPE 1-2 phase 3, randomized, controlled, multicenter, open-label clinical trial. Patients were randomly assigned (1:1 stratified by study site, type of organ, and time since transplantation) to receive 1 (control group) or 2 doses (booster the influenza 5 weeks apart.A total 499 SOTR enrolled. Although seroconversion at 10 did meet...
Blindness due to corneal diseases is a common pathology affecting up 23 million individuals worldwide. The tissue-engineered anterior human cornea, which currently being tested in Phase I/II clinical trial treat severe trophic ulcers with preliminary good feasibility and safety results. This bioartificial cornea based on nanostructured fibrin-agarose biomaterial containing allogeneic stromal keratocytes epithelial cells, mimicking the native terms of optical, mechanical, biological behavior....
Introduction There is a need to find alternatives the use of human donor corneas in transplants because limited availability organs, incidence graft complications, as well inability successfully perform corneal transplant patients presenting limbal deficiency, neo-vascularized or thin corneas, etc. We have designed clinical trial test nanostructured fibrin-agarose substitute combining allogeneic cells that mimics anterior native cornea terms optical, mechanical and biological behaviour....
Corneal diseases are among the main causes of blindness, with approximately 4.6 and 23 million patients worldwide suffering from bilateral unilateral corneal respectively. The standard treatment for severe is transplantation. However, relevant disadvantages, particularly in high-risk conditions, have focused attention on search alternatives.We report interim findings a phase I-II clinical study evaluating safety preliminary efficacy tissue-engineered substitute composed nanostructured...
The presence of the cyclic nucleotides 3',5'-cyclic adenyl monophosphate (cAMP) and guanyl (cGMP) in plants is now generally accepted. In addition, cAMP cGMP have been implicated regulation important plant processes such as stomatal functioning, monovalent divalent cation fluxes, chloroplast development, gibberellic acid signalling, pathogen response gene transcription. However, very little known regarding components nucleotide signalling plants. this addendum, evidence for specific...
Alzheimer disease (AD) is a progressive neurodegenerative disorder affecting the elderly with prevalence of 7.1% in women and 3.3% men. Sex-related patterns have been reported prognosis, biomarker status, risk factors. Despite this, interaction sex has received limited attention, AD trials persistently recruiting lower numbers than population distribution lack information on sex-disaggregated effects anti-dementia therapies. This first study aiming to identify role selection for screening...
Abstract Between 15% and 30% of HIV-infected subjects fail to increase their CD4+ T-cell counts despite continuous viral suppression (immunological nonresponders [INRs]). These have a higher morbidity mortality rate, but there are no effective treatments reverse this situation so far. This study used data from an interrupted phase I/II clinical trial evaluate safety immune recovery after INRs were given four infusions, at baseline weeks 4, 8, 20, with human allogeneic mesenchymal stromal...
Despite administration of annual influenza vaccination, influenza-associated complications in transplant recipients continue to be an important cause hospitalization and death. Although vaccination has been proven the most effective measure reduce infection after transplantation, are still vulnerable infections, with lower serological responses compared general population. In order assess efficacy safety alternative immunization scheme for solid organ recipients, TRANSGRIPE1-2 Study Group...
227 Background: A.A has been approved for the treatment of mCRPC before and after docetaxel. The standard regime consists on daily A.A. 1.000 mg in a fasting state along with prednisone 10mg q.d. However, data from pharmacokinetic (PK) studies patients (pts) healthy volunteers revealed significant food-effect up to 7-10 folder increase area under plasma concentration-time curve (AUC) when is given food, specially fat content, [Chi KN, J Clin Pharmacol 2015]. Methods: ABIFOOD phase I,...
Cellular therapies have been increasingly applied to diverse human diseases. Intracoronary infusion of bone marrow-derived mononuclear cells (BMMNC) has demonstrated improve ventricular function after acute myocardial infarction. However, less information is available about the role BMMNC therapy for treatment dilated myocardiopathies (DCs) non-ischemic origin. This article presents methodological description a study aimed at investigating efficacy intracoronary injection autologous BMMNCs...
Abstract Background: Alzheimer disease (AD) is a progressive neurodegenerative disorder affecting the elderly with prevalence of 7.1% in women and 3.3% men aged 55 or older. Sex-related patterns have been reported prognosis, biomarker status risk factors. Despite this, interaction sex has received limited attention, AD trials persistently recruiting lower numbers than population distribution lack information on sex-disaggregated effects anti-dementia therapies. This first study aiming to...