Roke I. Oruezábal

ORCID: 0000-0002-0654-9227
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About
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Research Areas
  • Legume Nitrogen Fixing Symbiosis
  • Plant nutrient uptake and metabolism
  • Antimicrobial agents and applications
  • Microbial Community Ecology and Physiology
  • Burn Injury Management and Outcomes
  • Microbial bioremediation and biosurfactants
  • Ocular Surface and Contact Lens
  • Plant-Microbe Interactions and Immunity
  • Nematode management and characterization studies
  • MicroRNA in disease regulation
  • Extracellular vesicles in disease
  • Soil Carbon and Nitrogen Dynamics
  • Corneal surgery and disorders
  • Microbial Metabolites in Food Biotechnology
  • Wound Healing and Treatments
  • Corneal Surgery and Treatments
  • Wastewater Treatment and Nitrogen Removal
  • Circular RNAs in diseases

Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla
2020

Universidad Autónoma de Madrid
2003-2010

ABSTRACT Rhizoremediation of organic chemicals requires high-level expression biodegradation genes in bacterial strains that are excellent rhizosphere colonizers. Pseudomonas fluorescens F113 is a biocontrol strain was shown to be an colonizer numerous plant rhizospheres, including alfalfa. Although derivative expressing polychlorinated biphenyl (PCB) (F113pcb) has been reported previously, this shows low level bph gene expression, limiting its rhizoremediation potential. Here, system...

10.1128/aem.71.5.2687-2694.2005 article EN Applied and Environmental Microbiology 2005-05-01

Blindness due to corneal diseases is a common pathology affecting up 23 million individuals worldwide. The tissue-engineered anterior human cornea, which currently being tested in Phase I/II clinical trial treat severe trophic ulcers with preliminary good feasibility and safety results. This bioartificial cornea based on nanostructured fibrin-agarose biomaterial containing allogeneic stromal keratocytes epithelial cells, mimicking the native terms of optical, mechanical, biological behavior....

10.1002/term.2951 article EN cc-by-nc-nd Journal of Tissue Engineering and Regenerative Medicine 2019-08-02

Abstract Background The bacterial Hfq protein is able to interact with diverse RNA molecules, including regulatory small non-coding RNAs (sRNAs), and thus it recognized as a global post-transcriptional regulator of gene expression. Loss has an extensive impact in physiology which several animal pathogens influences virulence. Sinorhizobium meliloti model soil bacterium known for its ability establish beneficial nitrogen-fixing intracellular symbiosis alfalfa. Despite the predicted general...

10.1186/1471-2180-10-71 article EN cc-by BMC Microbiology 2010-03-06

Abstract Background Treatment of patients affected by severe burns is challenging, especially due to the high risk Pseudomonas infection. In present work, we have generated a novel model bioartificial human dermis substitute tissue engineering treat infected wounds using fibrin-agarose biomaterials functionalized with nanostructured lipid carriers (NLCs) loaded two anti- antibiotics: sodium colistimethate (SCM) and amikacin (AMK). Results show that tissue-like substitutes strong...

10.1186/s12951-020-00732-0 article EN cc-by Journal of Nanobiotechnology 2020-11-23

When grown under standard conditions, Sinorhizobium meliloti EFB1 simultaneously produces two acidic exopolysaccharides, succinoglycan and galactoglucan, yielding very mucoid colonies. In this strain, MucR is essential for galactoglucan synthesis. A mutation in the mucS gene resulted less colonies than wild-type EFB1. This mucS- strain was complemented to phenotype by cloned gene, indicating that necessary a level of production. Reverse transcription-polymerase chain reaction analysis exp...

10.1094/mpmi.2002.15.1.54 article EN Molecular Plant-Microbe Interactions 2002-01-01

Extracellular vesicles derived from mesenchymal stromal cells (MSC-EVs) are gaining interest for medical purposes. The promising therapeutic effects exhibited in both preclinical and clinical studies have suggested that they may become an alternative certain applications to cell-based therapies, which subjected stricter regulations. commercial exploitation of these candidates requires a proper patent strategy the industry public research organizations. Here, we performed global literature...

10.2174/1872208316666220303095217 article EN Recent Patents on Biotechnology 2022-03-04
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