A5021482183- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Bacterial Infections and Vaccines
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Streptococcal Infections and Treatments
- Astronomical Observations and Instrumentation
- Tuberculosis Research and Epidemiology
- Viral Infections and Immunology Research
- Infective Endocarditis Diagnosis and Management
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Urinary Tract Infections Management
- Pediatric Urology and Nephrology Studies
- Astronomy and Astrophysical Research
- Pharmacological Effects and Assays
- Pharmaceutical studies and practices
- Child and Adolescent Health
- Infectious Diseases and Tuberculosis
- Hepatitis Viruses Studies and Epidemiology
Hospital Universitari Germans Trias i Pujol
2014-2025
Universidad Fernando Pessoa Canarias
2020-2024
Universitat Autònoma de Barcelona
2015-2024
Centro de Astrobiología
2024
Universidad Autónoma de Madrid
2011-2023
Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
2022-2023
Institut Català de la Salut
2023
Vall d'Hebron Hospital Universitari
2016-2022
Vall d'Hebron Institut de Recerca
2016-2022
Instituto de Salud Carlos III
2017-2022
MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 (IL-1Rs). deficiency in mice leads to susceptibility broad range of pathogens experimental settings infection. We describe distinct situation natural setting human Nine children with autosomal recessive suffered from life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease. However, these patients were otherwise healthy, normal resistance other microbes....
A 1-d point-prevalence study was performed with the aim of describing characteristics conventional mechanical ventilation in intensive care units ICUs from North America, South Spain, and Portugal. The involved 412 medical-surgical 1,638 patients receiving at moment study. main outcome measures were characterization indications for initiation ventilation, artificial airways used to deliver ventilator modes settings, methods weaning. median age 61 yr, duration time 7 d. Common included acute...
Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid differentiation factor (MyD)88 deficiencies impair Toll-like receptor (TLR)- receptor-mediated immunity. We documented the clinical features outcome of 48 patients with IRAK-4 deficiency 12 MyD88 deficiency, from 37 kindreds in 15 countries. The were indistinguishable. There no severe viral, parasitic, fungal diseases, range bacterial infections was narrow. Noninvasive occurred 52 patients, a high incidence...
This randomized, double-blind trial was designed to determine the benefit of high and cumulative doses flunisolide added salbutamol in patients with acute asthma emergency room (ER). Ninety-four who presented an ER for treatment exacerbation were assigned a fashion receive placebo (n = 47) or combined 47). Both drugs administered successively through metered-dose inhaler spacer at 10-min intervals 3 h (400 μ g 1 mg every 10 min). In both groups, FEV1 peak expiratory flow rate (PEFR) improved...
To validate procalcitonin (PCT) level as the best biological marker to distinguish between bacterial and aseptic meningitis in children emergency department.Secondary analysis of retrospective multicenter hospital-based cohort studies.Six pediatric or intensive care units tertiary centers 5 European countries.Consecutive aged 29 days 18 years with acute meningitis.Univariate meta-analysis compare performance blood parameters (PCT level, C-reactive protein white cell count, neutrophil count)...
El 31 de diciembre 2019, la Comisión Municipal Salud y Sanidad Wuhan (provincia Hubei, China) informó sobre existencia 27 casos neumonía etiología desconocida con inicio síntomas el 8 diciembre, incluyendo 7 graves, exposición común a un mercado marisco, pescado animales vivos en ciudad Wuhan. enero 2020, las autoridades chinas identificaron como agente causante del brote nuevo tipo virus familia Coronaviridae, denominado temporalmente «nuevo coronavirus», 2019-nCoV. 30 2020 Organización...
We designed a larger, double-blind, randomized, prospective trial to test our hypothesis that patients with acute asthma given combination high dose therapy ipratropium bromide (IB) and β2-agonists will have greater improvement in pulmonary function fewer hospital admissions than those alone. One hundred eighty (mean age ± SD, 34.3 10.5 yr) who presented an emergency department (ED) for treatment of exacerbation (baseline FEV1 < 50% predicted) were assigned double-blind fashion receive...
Although vaccination has been proved to be a safe, efficacious, and cost-effective intervention, immunisation rates remain suboptimal in many European countries, resulting poor control of vaccine-preventable diseases. The Summit Independent Vaccination Experts focused on the perception vaccines by general public healthcare professionals discussed ways improve vaccine uptake Europe. Despite substantial impact importance media, were identified as main advocates for most important source...
To ascertain the incidence and prevalence of juvenile idiopathic arthritis (JIA) in Catalonia (autonomous region northeast Spain), examined according to currently established disease subtypes.Before initiating study, we conducted an educational programme on paediatric rheumatology, addressed all general paediatricians Catalonia. A 2-year (2004-2006), prospective, population-based study was then carried out determine JIA. Prospective retrospective data retrieval performed calculate...
Listeria monocytogenes is the third most frequent cause of bacterial meningitis. The aim this study to know incidence and risk factors associated with development acute community-acquired Lm meningitis in adult patients evaluate clinical features, management, outcome prospective case series. A descriptive, prospective, multicentric carried out 9 hospitals Spanish Network for Research Infectious Diseases (REIPI) over a 39-month period. All adults admitted participating diagnosis (Ac-ABM) were...
Recientemente se ha aprobado en Europa y España el uso de nirsevimab, un anticuerpo monoclonal (AcM) para la prevención enfermedad por virus respiratorio sincitial (VRS). Facilitar unas recomendaciones administración nirsevimab VRS. Para elaboración estas recomendaciones, decidió realizar una revisión crítica literatura, utilizando metodología Delphi GRADE. Se definió grupo expertos. realizaron tres rondas definir las preguntas, manifestarse a favor o contra, graduar recomendación, acuerdo...