A5042022075- Burn Injury Management and Outcomes
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Antifungal resistance and susceptibility
- Thermal Regulation in Medicine
- Climate Change and Health Impacts
- Cardiac Arrest and Resuscitation
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Disaster Response and Management
- Hemodynamic Monitoring and Therapy
- Esophageal and GI Pathology
- Adrenal Hormones and Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Kidney Injury Research
- Nosocomial Infections in ICU
- Respiratory viral infections research
- Muscle and Compartmental Disorders
- Infectious Diseases and Mycology
- Pneumocystis jirovecii pneumonia detection and treatment
- Musculoskeletal synovial abnormalities and treatments
- Myasthenia Gravis and Thymoma
Hospital Universitario La Paz
2012-2024
Hospital La Paz Institute for Health Research
2014-2016
Abstract Background Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study investigate associations between mortality and variables measured during first three days ventilation with intubated at ICU admission. Methods Multicenter, observational, cohort includes consecutive admitted 44 Spanish ICUs February 25 July 31, 2020, who required intubation admission for more than days. We collected demographic clinical data prior...
Abstract Background The relative contribution of the different components mechanical power to mortality is a subject debate and has not been studied in COVID-19. aim this study evaluate both total impact each on well-characterized cohort patients with COVID-19-induced acute respiratory failure undergoing invasive ventilation. This secondary analysis CIBERESUCICOVID project, multicenter observational including fifty Spanish intensive care units that included COVID-19 mechanically ventilated...
Severely burned patients have altered drug pharmacokinetics (PKs), but it is unclear how different they are from those in other critically ill patient groups. The aim of the present study was to compare population micafungin plasma and burn eschar severely with peritoneal fluid postsurgical intra-abdominal infection. Fifteen were compared 10 infection; all treated 100 150 mg/day micafungin. Micafungin concentrations serial blood, fluid, tissue samples determined subjected a pharmacokinetic...
We used metagenomics to analyze one sputum sample from a patient with symptoms of respiratory infection that yielded negative results for all pathogens tested. detected two viral genomes could be assembled and showed sequence similarity redondoviruses, recently described group within the CRESS-DNA viruses. One hundred samples were screened presence these viruses using specific primers. was positive same viruses, another them. These findings raise questions about possible role redondoviruses...
The current definition of ARDS was established in 1994 by the AECC. In 2011 emerged Berlin definition. aim this study to find a new approach from impact an ICU and analyze APACHE II score, days mechanical ventilation (MV), duration mortality.
Severe burns result in rapid loss of intravascular volume due to development a severe capillary leak and hypovolemic shock. It is widely accepted that traditional markers, such as blood pressure urinary output, are useful but do not sufficiently reflect global perfusion, regional microcirculation or reversal Blood lactate concentration used ICUs reliable prognostic marker tissue hypoxia. Our aim determine whether the percentage clarified first 24 hours valid guide for resuscitation.
Abstract Background Tracheostomy is one of the most frequent techniques in intensive care units (ICU). Fiberoptic bronchoscopy (FB) a safety measure when performing percutaneous dilatational tracheostomy (PDT), but controversy surrounding routine use FB as part procedure remains open. National surveys some European countries showed that non-standardized. Retrospective studies have not shown significant difference complications between procedures performed with or without bronchoscope....
Abstract Introduction: Inhalation injury remains a significant cause of morbidity and mortality in critically ill burn patients. To improve this prognosis, it might be useful to understand the haemodynamic impact inhalation during initial resuscitation phase. We studied hemodynamic changes patients with injury, as well fluid volume used whether was related mortality. Methods: designed prospective, single-centre observational 4-year study. Patients criteria major burns were included. Our...
Mucormycosis is a devastating disease most commonly seen in immunosuppressed individuals. It has the propensity to disseminate humans and cause rhinocerebral, pulmonary, gastrointestinal, cutaneous infections. This study focuses on mucormycosis, incidence, epidemiologic characteristics mortality intensive care medicine.
It is unknown whether lung-protective ventilation applied in burn patients and they benefit from it. This study aimed to determine practices intensive care units (ICUs) investigate the association between number of ventilator-free days alive at day 28 (VFD-28).This an international prospective observational cohort including adult requiring mechanical ventilation. Low tidal volume (VT) was defined as VT ≤ 8 mL/kg predicted body weight (PBW). Levels positive end-expiratory pressure (PEEP)...
Burn injuries remain a significant problem with high associated morbidity and mortality, long average stays costs. The aim of our study is to analyze the epidemiology mortality critical burn patients admitted ICU at university hospital in Madrid, Spain.
The objective is to analyze the epidemiology and mortality of critical burn patients with inhalation injury.
Sequential Organ Failure Assessment (SOFA) is useful to assess organ dysfunction in burn patients [1]. The aim of this study was determine the change from admission day 3.
Micafungin (MCF) is an echinocandin agent with broad activity against Candida spp., which are frequently isolated in blood and eschar cultures of burned patients, who present different pharmacokinetics (PK) characteristics. Due to the limited information about its PK, we investigate MCF levels plasma burn tissues this population.
HIV infection is a major public health problem in the world. The use of prophylaxis against opportunist and introduction HAART 1996 increased life expectancies. therapeutic ICU resources for patients has been controversial, questioning admission these especially advanced stages disease, given poor prognosis. aim this study was to determine experience past 15 years relation income an ICU.
Introduction: A number of target points have been used for resuscitation in severely burned patients with conflicting results. Hypothesis: The aim our study was to evaluate the use guided transpulmonary thermodilution targets lower than normal. Methods: 132 admitted critical burn care unit were included into a prospective over 26-month period. Cardiac index (CI), Intrathoracic blood volume (ITBV), Extravascular lung water (EVLW) and arterial lactates obtained throughout first 72h. Fluid...