A5058861221- Obstructive Sleep Apnea Research
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Tracheal and airway disorders
- Cardiovascular and Diving-Related Complications
- Cardiovascular Disease and Adiposity
- Circadian rhythm and melatonin
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Sleep and related disorders
- Extracellular vesicles in disease
- Thermal Regulation in Medicine
- Dysphagia Assessment and Management
- Metabolomics and Mass Spectrometry Studies
- Assistive Technology in Communication and Mobility
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Adipose Tissue and Metabolism
- Cardiovascular Health and Disease Prevention
- Functional Brain Connectivity Studies
- Sleep and Work-Related Fatigue
- Cerebral Palsy and Movement Disorders
- Sepsis Diagnosis and Treatment
Hospital Universitari Arnau de Vilanova
2020-2025
Biomedical Research Institute of Lleida
2019-2025
Instituto de Salud Carlos III
2021-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2020-2025
Universitat de Lleida
2024
Centro de Investigación Biomédica en Red
2021-2023
Comunidad de Madrid
2021
Hospital Universitario La Paz
2004
We evaluated whether the time between first respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae.
To evaluate the sleep and circadian rest-activity pattern of critical COVID-19 survivors 3 months after hospital discharge.Observational, prospective study.Single-center study.One hundred seventy-two consecutive admitted to ICU with acute respiratory distress syndrome.Seven days actigraphy for assessment; validated questionnaires; tests at 3-month follow-up.The cohort included 172 patients, mostly males (67.4%) a median (25th-75th percentile) age 61.0 years (52.8-67.0 yr). The number was...
OBJECTIVES: To investigate the sleep and circadian health of critical survivors 12 months after hospital discharge to evaluate a possible effect severity disease within this context. DESIGN: Observational, prospective study. SETTING: Single-center PATIENTS: Two hundred sixty patients admitted ICU due severe acute respiratory syndrome coronavirus 2 infection. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The cohort was composed 260 (69.2% males), with median (quartile 1–quartile 3) age...
The long-term clinical management and evolution of a cohort critical COVID-19 survivors have not been described in detail. We report prospective observational study patients admitted to the ICU between March August 2020. follow-up post-COVID consultation comprised symptoms, pulmonary function tests, 6-minute walking test (6MWT), chest computed tomography (CT). Additionally, questionnaires evaluate prevalence post-COVID-19 syndrome were administered at 1 year. A total 181 during period. They...
Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Current core cerebrospinal fluid (CSF) AD biomarkers, widely employed for diagnosis, require lumbar puncture to be performed, making them impractical as screening tools. Considering the role of sleep disturbances in AD, recent research suggests quantitative electroencephalography features potential non-invasive biomarkers pathology. However, analysis comprehensive polysomnography (PSG) signals remains...
The use of continuous positive airway pressure prevents an increase in blood normotensive subjects with a dipping pattern and severe obstructive sleep apnoea. Background : effects (CPAP) on (BP) subjects, particularly among those BP pattern, remain uncertain, raising questions about its indication for this group patients. We assessed the impact CPAP apnoea (OSA). Methods Randomised, parallel, prospective, controlled trial. Inclusion criteria were apnoea-hypopnea index ≥30 events/hour, mean...
Abstract Background Survivors of critical illness endure long-lasting physical and mental challenges. Despite the persistence poor sleep quality in a considerable proportion patients at 12-month follow-up, studies with assessments exceeding this period are limited. We aimed to investigate trajectory over 24 months following illness. Methods Observational, prospective study. Patients diagnosed SARS-CoV-2 infection were recruited during intensive care unit stay. Evaluations (Pittsburgh Sleep...
A haemophilia-specific health-related quality-of-life questionnaire (named 'Hemofilia-QoL') was developed to assess in adults with haemophilia, and psychometrically tested. Seventy-three interviews haemophilia patients health care professionals were used generate the items included questionnaire, expert ratings on formulated screen them for potential omission. This followed by psychometric testing a sample of 35 patients. Preliminary revised version, which contains 10 domains (physical...
Background Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea (OSA), but compliance often unsatisfactory. Objective The aim of this study was to assess the effectiveness and cost-effectiveness intelligent monitoring system improving CPAP compliance. Methods This a prospective, open label, parallel, randomized controlled trial including 60 newly diagnosed patients with OSA requiring (Apnea–Hypopnea Index [AHI] >15) from Lleida, Spain....
Previous studies challenge the impact of obstructive sleep apnea (OSA) once patients are diagnosed with Alzheimer's disease (AD). Nevertheless, OSA recognizably disrupts sleep, and relevant associations between AD pathological markers, cognition have been demonstrated. We aimed to further explore this, evaluating each breathing cessation event that compose apnea-hypopnea index (AHI) structure finally investigate whether this was related increased levels markers higher cognitive...
A non-dipping blood pressure (BP) pattern, which is frequently present in patients with obstructive sleep apnea (OSA), confers high cardiovascular risk. The mechanisms connecting these two conditions remain unclear. In the study we performed a comprehensive analysis of metabolipidome that aims to provide new insights into molecular link between OSA and dysregulation circadian BP rhythmicity. This was an observational prospective longitudinal involving adults suspected who were subjected full...
Background There is a close relationship between obstructive sleep apnoea (OSA) and resistant hypertension (RH). However, studies assessing the long-term effect of diagnosing treating OSA on blood pressure (BP) control in these patients are lacking. Methods To address this gap, we recruited 478 RH from units followed them prospectively after they were screened for through study. By performing 24-h ambulatory BP monitoring (ABPM) annually, management was assessed. Results The had median...
<b><i>Background:</i></b> Obstructive sleep apnea (OSA) is a common disease caused by repeated episodes of collapse the upper airway during and associated with development cardiovascular (CVD). However, there high heterogeneity in impact OSA on patients. Until now, profile patients at risk developing CVD has not been defined, including measurable variables that could be used to predict patient OSA. <b><i>Objective:</i></b> The aim this study...
Rationale Approximately 60% of the patients with obstructive sleep apnoea suffer from a positional effect, and approximately 25% these present events only in supine position. Objective To validate new vibrating device evaluate its efficacy reducing Apnoea–Hypopnoea Index total time position without disturbing sleep. Methods A 128 were recruited for this multicentre, prospective, parallel, randomised controlled trial distributed three arms (general recommendations, inactive active device)....
The influence of body position in obstructive sleep apnoea patients is well known. A positional therapy device placed at the forehead has proven to be effective reducing severity (POSA) symptoms. aim study was evaluate patients' compliance and satisfaction short term mid-term.A post hoc analysis a randomised controlled trial conducted using an inactive (ID) or active (AD) for 3 months. primary outcomes were usage percentage with good (defined as use more than 4 hours per night 70% nights...
<b>Background:</b> Assessments to evaluate whether the effects of intensive care unit (ICU) on sleep and circadian health persist in long term are scarce. <b>Objective:</b> To critical survivors after a 12-month follow-up. <b>Methods:</b> Prospective, observational study. Critical patients due SARS-CoV-2 infection were recruited during ICU stay. Clinical evaluations including Pittsburgh Sleep Quality Index (PSQI) actigraphy (7 days) performed 3, 6, 12 months hospital discharge....