Background and purpose The COVID‐19 epidemic is affecting almost all individuals worldwide, patients with Alzheimer’s disease (AD) amnesic mild cognitive impairment (MCI) are particularly at risk due to their characteristics age. We analysed the impact of pandemic on these patients’ neuropsychiatric symptoms quality life after 5 weeks lockdown in Spain. Methods A total 40 a diagnosis MCI ( n = 20) or AD from Cognitive Stimulation Program Disorders Unit were evaluated. All had undergone...

Fatty acids (FAs) are the building blocks of complex lipids and signaling compounds; role lipidome fatty acid profile (LFA) in AD progression remains unclear.

We compared the clinical and analytical performance of Alzheimer’s disease (AD) plasma biomarkers measured using single-molecule array (Simoa) Lumipulse platforms. quantified levels amyloid beta 42 (Aβ42), Aβ40, phosphorylated tau (Ptau181), total in 81 patients with mild cognitive impairment (MCI), 30 AD, 16 non-AD dementia. found a strong correlation between Simoa methods. Concerning diagnosis, Ptau181/Aβ42 (AUC 0.739, 95% CI 0.592–0.887) Aβ42 0.735, 0.589–0.882 AUC 0.733, 0.567–0.900) had...

Abstract INTRODUCTION Changes in sleep physiology can predate cognitive symptoms by decades persons with Alzheimer's disease (AD), but it remains unclear which characteristics predict and neurodegenerative changes after AD onset. METHODS Using data from a prospective cohort of mild to moderate ( n = 60), we analyzed non‐rapid eye movement spindles slow oscillations (SOs) at baseline their associations amyloid beta (Aβ) tau cognition 3‐year follow‐up. RESULTS Higher spindle SO activity...

Introduction: Obstructive sleep apnoea (OSA) is the disorder most frequently found in patients with Alzheimer's disease (AD). The intermittent hypoxia (IH) caused by OSA may participate AD pathogenesis through increase oxidative damage and inflammation. We aimed to identify inflammatory redox genes differentially expressed blood from severe compared those nonsevere OSA. Methods: included 40 diagnosed based on clinical manifestations biomarker levels cerebrospinal fluid (CSF). Severe or...

Introduction: In preclinical Alzheimer's disease (AD), oxidative stress induces non-enzymatic protein damage-detected as cerebrospinal fluid (CSF) biomarkers-and disrupts sleep-related networks, altering sleep electroencephalographic patterns. Due to the invasiveness of CSF sampling, quantitative electroencephalography (qEEG) is proposed a non-invasive alternative for predicting oxidatively modified levels via Machine Learning (ML). Methods: Forty-two mild-to-moderate AD patients underwent...

Manual ELISA assays are the most commonly used methods for quantification of biomarkers; however, they often show inter- and intra-laboratory variability that limits their wide use. Here, we compared Innotest method with two fully automated platforms (Lumipulse Elecsys) to determine whether these new can provide effective substitutes assays. We included 149 patients AD ( n = 34), MCI 94) non-AD dementias 21). Aβ42, T-tau, P-tau were quantified using (Innotest, Fujirebio Europe), CLEIA on a...

Abstract Background Obstructive sleep apnoea (OSA) has a high prevalence in patients with Alzheimer’s disease (AD). Both conditions have been shown to be associated lipid dysregulation. However, the relationship between OSA severity and alterations metabolism brains of AD yet fully elucidated. In this context, we examined cerebrospinal fluid (CSF) lipidome suspected identify potential diagnostic biomarkers provide insights into pathophysiological mechanisms underlying effect on AD. Methods...

Proton pump inhibitors (PPIs) are among the most prescribed medications. Previous epidemiological studies have presented contradictory results about PPIs and risk of dementia. Our objective was to investigate association between use an increasing incident AD or non-AD dementias. A community-based retrospective cohort study conducted based on data available from 1st January 2002 31st December 2015 in Catalan health service (CatSalut) system. This included all PPI users (N = 36,360) non-users...

The majority of studies investigating the association between sleep and Alzheimer's disease (AD) biomarkers have been performed in healthy participants. Our objective was to investigate several that reflect distinct aspects AD physiopathology. cohort included 104 individuals with mild-moderate AD. participants were submitted one-night polysomnography, cerebrospinal fluid collected following morning measure selected associated amyloid deposition, tau pathology, neurodegeneration, axonal...

Alterations in circadian rhythms are present the presymptomatic stage of Alzheimer's disease (AD), possibly contributing to its pathogenesis. However, it is unknown whether such alterations associated with worse outcomes once individuals diagnosed symptomatic disease. We aimed evaluate association between rest-activity pattern and AD-related features patients mild-moderate AD.We assessed consecutive AD through actigraphy for 14 days. Cerebrospinal fluid was obtained determine levels...

We evaluated the influence of untreated obstructive sleep apnoea (OSA) on magnitude cognitive decline and several subdomains in patients with mild-to-moderate Alzheimer's disease. In this single-centre study, 144 were recruited prospectively from a impairment unit underwent overnight polysomnography. The mean± sd change Disease Assessment Scale subscale (ADAS-cog) score at 12 months was 3.19±5.61 non-OSA group 0.08±5.62 OSA group, an intergroup difference −3.36 (95% CI 0.19–0.16; p=0.002)....

Progressive cognitive decline is the most relevant clinical symptom of Alzheimer's disease (AD). However, rate highly variable between patients. Synaptic deficits are neuropathological event correlated with impairment in AD. Considering important role microRNAs (miRNAs) regulating synaptic plasticity, our objective was to identify plasma miRNAs associated patients mild AD.We analyzed 754 from 19 women diagnosed AD using TaqMan low-density array cards. The were grouped based on MMSE score...

Aberrant lipid metabolism has been strongly linked to Alzheimer's disease (AD) pathogenesis. However, the role of lipids in pathophysiological processes AD and their clinical progression is unclear. We hypothesized that plasma are associated with pathological hallmarks AD, from mild cognitive impairment (MCI) rate decline MCI patients. To evaluate our hypotheses, we analysed lipidome profile by liquid chromatography coupled mass spectrometry an LC-ESI-QTOF-MS/MS platform for 213 subjects...

Abstract Genetic, metabolic, and clinical evidence links lipid dysregulation to an increased risk of Alzheimer’s disease (AD). However, the role lipids in pathophysiological processes AD its progression is unclear. We investigated association between cerebrospinal fluid (CSF) lipidome pathological hallmarks AD, from mild cognitive impairment (MCI) rate decline MCI patients. The CSF was analyzed by liquid chromatography coupled mass spectrometry LC-ESI-QTOF-MS/MS platform for 209...

Understanding of Alzheimer disease (AD) is fundamental for early diagnosis and to reduce caregiver burden. The objective this study evaluate the degree understanding AD among informal caregivers different segments general population through Alzheimer's Disease Knowledge Scale (ADKS). We assessed knowledge in follow-up periods (less than one year, between 1 5 years, over years since diagnosis) individuals from population. ADKS scores were grouped into items: life impact, risk factors,...

Abstract Background MicroRNAs (miRNAs) are noncoding RNAs that highly relevant as disease biomarkers. Several studies explored the role of miRNAs in Alzheimer’s (AD) demonstrated their usefulness clinical identification. Nevertheless, may act endogenous controls (ECs) have not yet been established. The identification ECs would contribute to standardization these biomarkers AD. objective study was identify can be used Methods We evaluated 145 patients divided into two different cohorts. One a...

Benzodiazepines (BZDs) and Z-drugs (BZDRs) are among the most prescribed medications for anxiety insomnia, especially older adults. Our objective was to investigate association between use of BZDRs risk dementia.A community-based retrospective cohort study conducted based on data available from 2002 2015 in Catalan Health Service. This included all BZDR users (N = 83 138) nonusers 84 652) than 45 years. A minimum 5-year lag window an adjustment psychiatric problems were applied analysis.The...

The aim of this study was to investigate the usefulness Alzheimer's disease Cerebrospinal Fluid (CSF) biomarkers in predicting progression dementia patients with Mild Cognitive Impairment (MCI). One hundred and thirteen were consecutively recruited from April 2012 2014. Measurement CSF (amyloid-β42 (Aβ42), total tau (t-tau) phosphorylated (p-tau)) a neuropsychological evaluation performed for all patients. We categorized MCI as A+A- N+N- based on presence/absence amyloid pathology...

Abstract Study Objectives To investigate the association between sleep and cognitive decline of patients with mild-moderate Alzheimer’s disease. Methods Observational, prospective study, including consecutive diagnosed Cerebrospinal fluid was collected for amyloid-beta, total-tau, phospho-tau levels determination. Also, overnight polysomnography performed, followed by neuropsychological evaluations at baseline after 12 months follow-up. Principal component analysis revealed two profiles in...

El conocimiento de la enfermedad Alzheimer es fundamental para el diagnóstico precoz y reducir sobrecarga del cuidador. objetivo fue evaluar grado mediante Alzheimer's Disease Knowledge Scale en cuidadores informales diferentes segmentos población. Se evaluó a diferente periodo seguimiento (menor un año, entre 1-5 más 5 años desde diagnóstico) sujetos población general. La puntuación se agrupó distintos ítems: impacto vital, factores riesgo, síntomas, diagnóstico, tratamiento, progresión...