Anna Moncusí‐Moix
A5082870470- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- MicroRNA in disease regulation
- Obstructive Sleep Apnea Research
- Intensive Care Unit Cognitive Disorders
- Extracellular vesicles in disease
- Thermal Regulation in Medicine
- COVID-19 and Mental Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Circadian rhythm and melatonin
- Sleep and related disorders
- Neuroscience of respiration and sleep
- Sepsis Diagnosis and Treatment
- Tracheal and airway disorders
- Sleep and Wakefulness Research
- Cardiovascular and Diving-Related Complications
- Cancer-related molecular mechanisms research
- Mobile Health and mHealth Applications
- Family and Patient Care in Intensive Care Units
- Chronic Disease Management Strategies
- Alzheimer's disease research and treatments
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Issues in Pregnancy
- Erythropoietin and Anemia Treatment
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2020-2025
Biomedical Research Institute of Lleida
2020-2025
Hospital Universitari Arnau de Vilanova
2020-2025
Instituto de Salud Carlos III
2021-2025
Centro de Investigación Biomédica en Red
2022-2024
Universitat de Lleida
2023
Centre for Biomedical Network Research on Rare Diseases
2022-2023
Universitat de Barcelona
2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2023
Centro de Investigación en Red en Enfermedades Cardiovasculares
2022
The COVID-19 outbreak witnessed in the first months of 2020 has led to unprecedented changes society's lifestyles. In current study, we aimed investigate effect this unexpected context on sleep.During outbreak, performed an online survey with individuals formerly recruited for validation Spanish version sleep questionnaire Satisfaction, Alertness, Timing, Efficiency, and Duration (SATED). survey, asked participants complete previously answered questionnaires including Pittsburgh Sleep...
We evaluated whether the time between first respiratory support and intubation of patients receiving invasive mechanical ventilation (IMV) due to COVID-19 was associated with mortality or pulmonary sequelae.
OBJECTIVES: To investigate the sleep and circadian health of critical survivors 12 months after hospital discharge to evaluate a possible effect severity disease within this context. DESIGN: Observational, prospective study. SETTING: Single-center PATIENTS: Two hundred sixty patients admitted ICU due severe acute respiratory syndrome coronavirus 2 infection. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The cohort was composed 260 (69.2% males), with median (quartile 1–quartile 3) age...
To evaluate the sleep and circadian rest-activity pattern of critical COVID-19 survivors 3 months after hospital discharge.Observational, prospective study.Single-center study.One hundred seventy-two consecutive admitted to ICU with acute respiratory distress syndrome.Seven days actigraphy for assessment; validated questionnaires; tests at 3-month follow-up.The cohort included 172 patients, mostly males (67.4%) a median (25th-75th percentile) age 61.0 years (52.8-67.0 yr). The number was...
The long-term clinical management and evolution of a cohort critical COVID-19 survivors have not been described in detail. We report prospective observational study patients admitted to the ICU between March August 2020. follow-up post-COVID consultation comprised symptoms, pulmonary function tests, 6-minute walking test (6MWT), chest computed tomography (CT). Additionally, questionnaires evaluate prevalence post-COVID-19 syndrome were administered at 1 year. A total 181 during period. They...
Circulating cell-free microRNAs (miRNAs) are promising biomarkers for medical decision-making. Suitable endogenous controls essential to ensure reproducibility. We aimed identify and validate reference miRNAs qPCR data normalization in samples from SARS-CoV-2-infected hospitalized patients. used plasma (n = 170) COVID-19 patients collected at hospital admission (COVID-Ponent project, www.clinicaltrials.gov/NCT04824677). First, 179 were profiled using RT–qPCR. After stability assessment,...
The pathophysiology of COVID-19-related critical illness is not completely understood. Here, we analyzed the microRNA (miRNA) profile bronchial aspirate (BAS) samples from COVID-19 and non-COVID-19 patients admitted to ICU identify prognostic biomarkers fatal outcomes define molecular pathways involved in disease adverse events.Two patient populations were included (n = 89): (i) a study population composed critically ill patients; (ii) prospective cohort survivors non-survivors among...
There is a limited understanding of the pathophysiology postacute pulmonary sequelae in severe COVID-19. The aim current study was to define circulating microRNA (miRNA) profiles associated with function and radiologic features survivors SARS-CoV-2-induced ARDS. included patients who developed ARDS secondary SARS-CoV-2 infection (n = 167) group infected did not develop 33). Patients were evaluated 3 months after hospital discharge. follow-up complete evaluation chest computed tomography....
Abstract Background and Purpose The post‐acute sequelae of SARS‐CoV‐2 infection pose a significant global challenge, with nearly 50% critical COVID‐19 survivors manifesting persistent lung abnormalities. lack understanding about the molecular mechanisms effective treatments hampers their management. Here, we employed microRNA (miRNA) profiling to decipher systemic underpinnings pulmonary complications. Experimental Approach We conducted longitudinal investigation including 119 survivors. A...
Introduction The impact of the different ventilatory support modalities and timing intubation on longitudinal lung recovery trajectories in patients with severe COVID-19 is unknown. Methods A multicenter, prospective observational study conducted 52 Spanish intensive care units (ICUs) involving critically ill admitted between February 25th, 2020, to 28th, 2021. 1854 were followed after hospital discharge at 3, 6 12 months diffusing capacity (D LCO ) a chest imaging. Patients classified...
Abstract Background Survivors of critical illness endure long-lasting physical and mental challenges. Despite the persistence poor sleep quality in a considerable proportion patients at 12-month follow-up, studies with assessments exceeding this period are limited. We aimed to investigate trajectory over 24 months following illness. Methods Observational, prospective study. Patients diagnosed SARS-CoV-2 infection were recruited during intensive care unit stay. Evaluations (Pittsburgh Sleep...
The identification of critically ill COVID-19 patients at risk fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in patients. Second, constructed blood miRNA classifier the early prediction adverse ICU.This was multicenter, observational and retrospective/prospective study including 503 admitted to ICU from 19 hospitals. qPCR assays were performed plasma samples collected within 48 h upon admission. A 16-miRNA...
Progressive cognitive decline is the most relevant clinical symptom of Alzheimer's disease (AD). However, rate highly variable between patients. Synaptic deficits are neuropathological event correlated with impairment in AD. Considering important role microRNAs (miRNAs) regulating synaptic plasticity, our objective was to identify plasma miRNAs associated patients mild AD.We analyzed 754 from 19 women diagnosed AD using TaqMan low-density array cards. The were grouped based on MMSE score...
Background Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea (OSA), but compliance often unsatisfactory. Objective The aim of this study was to assess the effectiveness and cost-effectiveness intelligent monitoring system improving CPAP compliance. Methods This a prospective, open label, parallel, randomized controlled trial including 60 newly diagnosed patients with OSA requiring (Apnea–Hypopnea Index [AHI] >15) from Lleida, Spain....
Obstructive sleep apnea (OSA) is a chronic, heterogeneous and multicomponent disorder with associated cardiovascular metabolic alterations. Despite being the most common sleep-disordered breathing, it remains significantly undiagnosed condition. We examined plasma metabolome lipidome of patients suspected OSA, aiming to identify potential diagnosis biomarkers provide insights into pathophysiological mechanisms underlying disease. Additionally, we evaluated impact continuous positive airway...
Abstract Background MicroRNAs (miRNAs) are noncoding RNAs that highly relevant as disease biomarkers. Several studies explored the role of miRNAs in Alzheimer’s (AD) demonstrated their usefulness clinical identification. Nevertheless, may act endogenous controls (ECs) have not yet been established. The identification ECs would contribute to standardization these biomarkers AD. objective study was identify can be used Methods We evaluated 145 patients divided into two different cohorts. One a...
The clinical heterogeneity of COVID-19 suggests the existence different phenotypes with prognostic implications. We aimed to analyze comorbidity patterns in critically ill patients and assess their impact on in-hospital outcomes, response treatment sequelae.Multicenter prospective/retrospective observational study intensive care units 55 Spanish hospitals. 5866 PCR-confirmed had comorbidities recorded at hospital admission; biological parameters, procedures complications throughout stay;...
Bronchial aspirates (BAS) obtained during invasive mechanical ventilation (IMV) constitutes a useful tool for molecular phenotyping and decision making.To identify the proteomic determinants associated with disease pathogenesis, all-cause mortality respiratory sequelae in BAS samples from critically ill patients SARS-CoV-2-induced ARDS.Multicenter study including 74 COVID-19 non-COVID-19 ARDS. were by bronchoaspiration after IMV initiation. Three hundred sixty-four proteins quantified using...
The World Health Organization's strategy toward healthy aging fosters person-centered integrated care sustained by eHealth systems. However, there is a need for standardized frameworks or platforms accommodating and interconnecting multiple of these systems while ensuring secure, relevant, fair, trust-based data sharing use. H2020 project GATEKEEPER aims to implement test an open-source, European, standard-based, interoperable, secure framework serving broad populations citizens with...