A5086448548- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cardiovascular Disease and Adiposity
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and Diving-Related Complications
- Sleep and related disorders
- Erythropoietin and Anemia Treatment
- Adipose Tissue and Metabolism
- Asthma and respiratory diseases
- Sleep and Work-Related Fatigue
- Heart Rate Variability and Autonomic Control
- High Altitude and Hypoxia
- Blood transfusion and management
- Cardiovascular Syncope and Autonomic Disorders
- Sleep and Wakefulness Research
- Dietary Effects on Health
- Metabolomics and Mass Spectrometry Studies
Hospital Universitari Arnau de Vilanova
2017-2022
Biomedical Research Institute of Lleida
2015-2022
Hospital Arnau de Vilanova
2019-2022
Universitat de Lleida
2015-2019
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2019
Evaluation of microRNAs (miRNAs) could allow characterization the obstructive sleep apnea (OSA) and help diagnose it more accurately. We aimed to examine circulating miRNA profiles establish differences between non-OSA OSA patients. Additionally, we analyse effect continuous positive airway pressure (CPAP) treatment on profile. This observational, longitudinal study included 230 subjects referred Sleep Unit due suspected OSA. Expression profiling 188 miRNAs in plasma was performed 27 by...
The goal of this study was to assess the relationship between severity obstructive sleep apnoea (OSA) and levels carcinogenesis- tumour growth-related biomarkers in patients with cutaneous melanoma. This multicentre observational included who were newly diagnosed classified as non-OSA (apnoea–hypopnoea index (AHI) 0–5 events·h −1 ), mild OSA (AHI 5–15 ) moderate–severe >15 ). ELISAs performed analyse serum hypoxia- adhesion-related (vascular endothelial growth factor (VEGF), interleukin...
Rationale: Evidence suggests that the physiopathologic consequences of obstructive sleep apnea (OSA) resemble those induced by aging. Some studies report deleterious effects associated with OSA might be age dependent. Objectives: To evaluate association aging process and to determine whether this is maintained across different groups. Methods: This was an observational, prospective study including 599 patients suspected OSA. Five hallmarks were evaluated: alteration cellular communication...
Continuous positive airway pressure (CPAP) has a heterogeneous effect on blood (BP) in hypertensive patients. However, the of CPAP BP subjects regarding circadian pattern never been explored. This study aimed to assess BP, taking into consideration untreated is post hoc analysis Spanish Cohort for Study Effect Hypertension (CEPECTA), multicentre, randomised trial versus sham-CPAP patients with new-onset systemic hypertension and an apnoea–hypopnoea index >15 events·h −1 . We included whom...
Continuous positive airway pressure (CPAP) treatment reduces blood (BP) in obstructive sleep apnoea (OSA) and hypertensive patients, but there is a lack of data about the effects CPAP on BP normotensive patients.The aim study was to evaluate changes OSA individuals receiving treatment.We selected 131 outpatients with an apnoea/hypopnoea index (AHI) greater than 15 events/hour who required treatment. All patients underwent 24-h ambulatory monitoring (ABPM) at baseline after 6 months. In...
microRNAs (miRNAs) are non-coding RNAs highly relevant as biomarkers for disease. A seminal study that explored the role of miRNAs in obstructive sleep apnea syndrome (OSA) demonstrated their usefulness clinical management. Nevertheless, may act endogenous controls (ECs) have not yet been established. The identification ECs would contribute to standardization these OSA. objective is identify can be used We evaluated 100 patients divided into two different cohorts: a learning cohort 10...
Obstructive sleep apnea (OSA) is a chronic, heterogeneous and multicomponent disorder with associated cardiovascular metabolic alterations. Despite being the most common sleep-disordered breathing, it remains significantly undiagnosed condition. We examined plasma metabolome lipidome of patients suspected OSA, aiming to identify potential diagnosis biomarkers provide insights into pathophysiological mechanisms underlying disease. Additionally, we evaluated impact continuous positive airway...
<b><i>Background:</i></b> Obstructive sleep apnea (OSA) is a common disease caused by repeated episodes of collapse the upper airway during and associated with development cardiovascular (CVD). However, there high heterogeneity in impact OSA on patients. Until now, profile patients at risk developing CVD has not been defined, including measurable variables that could be used to predict patient OSA. <b><i>Objective:</i></b> The aim this study...
Abstract Recent studies have evaluated the potential of circulating microRNAs (miRNAs) as valuable biomarkers for characterizing obstructive sleep apnea (OSA) in males. The use miRNAs clinical indicators females is unknown. objective to identify a set be used endogenous controls (ECs) female patients with OSA. Then, analyze differences miRNA expression profile between and without This observational, longitudinal study included 85 suspected OSA who underwent polysomnography. was defined an...
Several studies have reported an association between microRNAs (miRNAs) and hypertension or cardiovascular disease (CVD). In a previous study performed on group of 38 patients, we observed cluster 3 miRNAs (miR-378a-3p, miR-100-5p, miR-486-5p) that were functionally associated with the system predicted favorable blood pressure (BP) response to continuous positive airway (CPAP) treatment in patients resistant (RH) obstructive sleep apnea (OSA) (HIPARCO score). However, little is known...
Abstract Background Hypoxia can reduce the levels of soluble receptor for advanced glycation end-products (sRAGE), a new anti-inflammatory biomarker COPD. We assessed sRAGE in patients with hypoxia-related diseases such as COPD, OSA and OSA-COPD overlap. Methods Plasma were measured 317 subjects at baseline (57 heathy nonsmokers [HNS], 84 healthy smokers [HS], 79 OSA, 62 COPD 35 overlap patients) 294 after one year follow-up (50 HNS, 74 HS, 77 60 33 overlap). Results After adjusting age,...
<b>Background:</b> OSA is highly prevalent among patients with resistant hypertension (RH). In RH OSA, the blood pressure (BP) response to adherent use of CPAP variable showing major reductions while in other BP remains unchanged or worsens. MicroRNAs (miRNA) have been identified as playing significant roles cardiovascular disease. <b>Aim:</b> To identify initial miRNA candidate biomarkers circulating miRNAs plasma responders and non-responders undergoing CPAP. <b>Methods:</b> 41 male were...
Abstract Background . Hypoxia can reduce the levels of soluble receptor for advanced glycation end-products (sRAGE), a new anti-inflammatory biomarker COPD. We assessed sRAGE in patients with hypoxia-related diseases such as COPD, OSA and OSA-COPD overlap. Methods Plasma were measured 317 subjects at baseline (57 heathy nonsmokers [HNS], 84 healthy smokers [HS], 79 OSA, 62 COPD 35 overlap patients) 294 after one year follow-up (50 HNS, 74 HS, 77 60 33 overlap). Results. After adjusting age,...
Abstract Background : Several studies report an association between microRNAs (miRNAs) and hypertension or cardiovascular disease. In a previous study, we observed cluster of three miRNAs (miR-378a-3p, miR-100-5p, miR-486-5p) functionally associated with the system that predicted favorable blood pressure response to continuous positive airway (CPAP) treatment in patients resistant (RH) obstructive sleep apnea (OSA) (HIPARCO score). However, little is known regarding molecular mechanisms...