A5052912870- Inflammatory Bowel Disease
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Cytokine Signaling Pathways and Interactions
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic factors in colorectal cancer
- Microscopic Colitis
- S100 Proteins and Annexins
- T-cell and B-cell Immunology
- Head and Neck Cancer Studies
- Obstructive Sleep Apnea Research
- Cancer, Hypoxia, and Metabolism
- Salivary Gland Disorders and Functions
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Tuberculosis Research and Epidemiology
- Redox biology and oxidative stress
- Oral Health Pathology and Treatment
- Diagnosis and treatment of tuberculosis
- Glioma Diagnosis and Treatment
- Extracellular vesicles in disease
- Autoimmune Bullous Skin Diseases
- Brain Metastases and Treatment
Institutul National Victor Babes
2008-2025
Carol Davila University of Medicine and Pharmacy
2024
National Institute of Pathology
2016-2023
Victor (Japan)
2016-2023
National Research Institute
2018
Institutul Clinic Fundeni
2017
University of Bucharest
2015
Lund University
2001
COVID-19 mRNA vaccines effectively reduce incidence of severe disease, hospitalisation and death. The biodistribution pharmacokinetics the mRNA-containing lipid nanoparticles (LNPs) in these are unknown humans. In this study, we used qPCR to track circulating blood at different time-points after BNT162b2 vaccination a small cohort healthy individuals. We found that vaccine-associated synthetic persists systemic circulation for least 2 weeks. Furthermore, transmission electron microscopy...
Introduction: Obstructive sleep apnoea (OSA) is the disorder most frequently found in patients with Alzheimer's disease (AD). The intermittent hypoxia (IH) caused by OSA may participate AD pathogenesis through increase oxidative damage and inflammation. We aimed to identify inflammatory redox genes differentially expressed blood from severe compared those nonsevere OSA. Methods: included 40 diagnosed based on clinical manifestations biomarker levels cerebrospinal fluid (CSF). Severe or...
Background/Objectives: Oral leukoplakia (OLK) is an oral mucosal lesion classified in the potentially malignant disorder group and associated with increased risk of transformation (MT). The aim this study was to compare clinical histopathological features two OLK groups, a smokers non-smokers. Methods: In retrospective study, cohort 154 patients divided into groups based on presence smoking as major factor. diagnoses were established via examination. Results: Females more abundant...
Objective: Our understanding of the pathophysiology pancreatic neuroendocrine tumors (PanNETs) remains incomplete, largely due to their historically underestimated incidence and perception these as rare slow-growing cancers. Additionally, conventional reliance on histological examination alone is gradually being supplemented by exploration introduction molecular biomarkers, such microRNAs (miRNAs). As miRNAs modulate expression multiple genes pathways involved in tumorigenesis PanNETs,...
The ozone layer in the Earth’s atmosphere filters solar radiation and limits unwanted effects on humans. A depletion of this shield triggered by a violent Sun would permit hazardous levels UV radiation, especially UVB range, to bombard surface, resulting potentially significant human health. concern for these adverse intensifies if we consider that is combined with secondary cosmic (SCR) components, such as protons muons, well terrestrial gamma rays. This research aims delve into intricate...
Genetic research has shaped the inflammatory bowel disease (IBD) landscape identifying nearly two hundred risk loci. Nonetheless, identified variants rendered only a partial success in providing criteria for differential diagnosis between ulcerative colitis (UC) and Crohn’s (CD). Transcript levels from affected intestinal mucosa may serve as tentative biomarkers improving classification of IBD. The aim our study was to identify gene expression profiles specific UC CD, endoscopically normal...
Colorectal cancer (CRC) is often characterized by mutations and aberrant DNA methylation within the promoters of tumor suppressor genes proto-oncogenes. The most frequent somatic occur KRAS BRAF genes. Mutations gene have been detected in approximately 40% patients, while less frequently at a rate 10%. In this study, levels 22 candidate were evaluated three types tissue: mucosal tumoral tissue from 18 CRC normal adjacent tissues 10 patients who underwent surgical resection, control group six...
microRNAs (miRNAs) have been proposed as promising molecular biomarkers for diagnosis, prognosis, and responsive therapeutic targets in different types of cancer, including colorectal cancer (CRC). In this study, we evaluated the expression levels 84 cancer-associated miRNAs a cohort 39 human samples comprising 13 peritumoral 26 tumoral tissues from surgical specimens CRC patients. KRAS mutations were detected 11 samples. first analysis, found 5 (miR-215-5p, miR-9-5p, miR-138-5p, miR378a-3p,...
Increased insulin-like growth factor (IGF) axis activity is associated with the development and progression of different types malignancies, including colorectal cancer (CRC). MicroRNAs (miRNAs) belonging to let-7 family have been reported target genes involved in this are known as tumor suppressors. In study, silico bioinformatic analysis was performed assess miRNA-mRNA interactions between eight miRNAs IGF signaling pathway, coding for receptors substrates. miRNAs' expression revealed that...
Colorectal cancer (CRC) is the third cause of cancer-related death worldwide. Screening programs can reduce CRC mortality rates by up to 60%. In line with European Union recommendations, Romania started first four regional pilot screening in 2020 (the ROCCAS II projects). This study reports interim performance indicators.
Background: Although Alzheimer's disease (AD) is associated with alterations of the central nervous system, this has an echo in blood that might represent a valuable source biomarkers for improved diagnosis, prognosis and monitoring drug response.Methods: We performed targeted transcriptomics study on 38 mild patients matched controls evaluating expression levels 136 inflammation 84 redox genes whole blood.Patients were diagnosed as AD based altered total TAU, phospho-TAU Abeta (1-42)...
Background and Aims: Therapeutic targets in ulcerative colitis (UC) have evolved over time from clinical remission to biological endoscopic remission. Histologic remains a debatable outcome due lack of data regarding its impact on long-term evolution. The development histologic activity scores has brought standardization. We aimed identify mucosal markers differentiating histological inflammation UC patients.
 Methods: gene expression levels 84 genes associated with inflammatory bowel...
Chronic low-grade inflammation and oxidative stress are present in most of the pathologic mechanisms underlying non-communicable diseases. Inflammation redox biomarkers might therefore have a value disease prognosis therapy response. In this context, we performed case-control study for assessing whole blood expression profile redox-related genes elderly subjects with various comorbidities.In 130 pathologies (cardiovascular disease, hypertension, dyslipidemia including hypercholesterolemia,...
Background: Pancreatic ductal adenocarcinoma (PDAC), the most prevalent neoplastic lethal pancreatic disease, has a poor prognosis and an increasing incidence. The insulin-like growth factor-1 receptor (IGF-1R) signaling pathway is considered to be contributing factor progression, metastasis, therapy resistance of PDAC. Currently available treatment options for PDAC are limited, but microRNAs (miRNAs) may represent new therapeutic strategy targeting genes involved in IGF-1R pathway. Method:...
Although causal associations between oral leukoplakia (OL), squamous cell carcinoma (OSCC) and high-risk human papillomavirus (HR-HPV) have been speculated upon in several reports, conclusive evidence has not presented. This study investigates whether the number of cases HR-HPV OL increased over time prevalence HR-HPV-positive differs various parts world.A total 432 patients with from Sweden, Brazil Romania were analysed. Patients divided into historical (1992-2002) contemporary (2011-2017)...
Abstract The development and progression of colorectal cancer (CRC) have been associated with inflammation processes that involve the overactivation NF‐κB signalling pathway. characterization expression profile in CRC is an important topic since suppression represents a potential therapeutic approach. In this study, we assessed levels 84 NF‐κB‐related genes paired tumoral (T) peritumoral (PT) tissues from 18 patients normal colonic mucosae, three miRNAs targeting most dysregulated revealed...
Burning Mouth Syndrome (BMS) is a chronic condition characterized by burning sensation in the oral mucosa, lasting more than 2 hours daily for 3 months, without clinical and/or laboratory evidence. BMS often comorbid with mood, and psychiatric disorders, complex pathophysiology interaction between impairments nociceptive processing psychologic function occurring. In this work, we aimed to define neuropsychological profile specific patients better management of disease. We conducted...
CD28 superfamily of immune costimulatory molecules could play an important role in autotolerance control. costimulation seems to be necessary for regulatory T cell (Treg) activation and successive suppressive activities involved autoimmunity protection. This study investigates expression, especially inducible costimulator fraction, on lymphocytes pemphigus vulgaris (PV) patients.CD28 expression was assessed 16 PV patients during acute attack. All 10 healthy control subjects were tested...