A5034382418- Inflammatory Bowel Disease
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Hepatitis C virus research
- Autoimmune and Inflammatory Disorders
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Celiac Disease Research and Management
- Neuroendocrine Tumor Research Advances
- Gastrointestinal motility and disorders
- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Digestive system and related health
- Hepatitis B Virus Studies
- Health, psychology, and well-being
- Pancreatitis Pathology and Treatment
- Vitamin D Research Studies
- Renal Diseases and Glomerulopathies
- Clostridium difficile and Clostridium perfringens research
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Bone health and osteoporosis research
- Optimism, Hope, and Well-being
- Systemic Lupus Erythematosus Research
Carol Davila University of Medicine and Pharmacy
2018-2025
Clinical Emergency Hospital Bucharest
2017-2025
Institutul Clinic Fundeni
2014-2024
Spitalul Universitar de Urgență Elias
2023
Romanian Academy
2021
University of Medicine and Pharmacy of Craiova
2021
Emergency University
2021
Monitoring disease activity in inflammatory bowel (IBD) is challenging since clinical manifestations do not represent reliable surrogates for an accurate reflection of the burden. Endoscopic remission had been most significant endpoint target last years; nevertheless, a remarkable proportion patients continue to relapse despite normal-appearing mucosa, highlighting that endoscopy may underestimate true extent disease. A subtle hint importance histology plays long-term course has endorsed by...
Abstract Background Biological therapy is the most important pathogenic treatment in moderate to severe Crohn’s disease (CD), but there are few studies literature that compare effectiveness and safety of several biological drugs. The aim this study efficacy different biologics as first line CD. Methods 326 patients from 6 Gastroenterology departments Bucharest, Iasi Cluj treated between 2006 2024 were included study. 47 excluded because they received only Mesalazine. 279 final analysis. main...
: Inflammatory bowel diseases are a main focus in current research, with diet being an emerging therapeutic line due to its links both onset and progression. A Western-style high processed foods, food additives, red meat, animal fat has been linked higher risk of developing IBD. The aim this study was establish association between anti-inflammatory exclusion maintenance remission Also, we assessed the efficacy safety compared non-dietary group possible effect IBD remission.
Genetic research has shaped the inflammatory bowel disease (IBD) landscape identifying nearly two hundred risk loci. Nonetheless, identified variants rendered only a partial success in providing criteria for differential diagnosis between ulcerative colitis (UC) and Crohn’s (CD). Transcript levels from affected intestinal mucosa may serve as tentative biomarkers improving classification of IBD. The aim our study was to identify gene expression profiles specific UC CD, endoscopically normal...
The study evaluated the evolution of incidence infections with Klebsiella in County Clinical Emergency Hospital Craiova (SCJUC), Romania. Also, we monitored antibiotic resistance over more than two years and detected changes to various antimicrobial agents. Our included 2062 patients (823 women 1239 men) hospitalised SCJUC during period 1st September 2017 30 June 2019. In 458 (22.21%) from total patients, collected samples (1116) were positive those, isolated 251 strains spp. We conducted a...
Recent research has shown that Western-style diets have been associated with an increased risk of inflammatory bowel diseases (IBD). Our aim was to examine the link between anti-inflammatory diet and maintenance IBD remission, as well assess potential therapeutic advantages this dietary approach in preserving remission.
Introduction Recent studies have suggested a higher recurrence rate of hepatocellular carcinoma (HCC) in patients with history HCC and hepatitis C virus (HCV)‐associated cirrhosis treated direct‐acting antiviral (DAA) agents. Material methods We conducted prospective analysis 24 HCV‐associated who received ombitasvir/paritaprevir/ritonavir+dasabuvir+ribavirin for 12 weeks. Prior therapies included resection (9/24 patients), radiofrequency ablation (RFA) (7/24) trans‐arterial...
Background and aims: inflammatory bowel disease development has been associated with several environmental factors, among which, diet can play a key role, probably due to westernized lifestyle.However, its involvement in the pathogenesis of (IBD) is difficult demonstrate.The aim this study was analyze dietary composition Romanian Belgian population IBD.Methods: an observational retrospective comparative performed using two European cohorts (Romanian Belgian).The IBD group included 76 53...
AFP (alpha-fetoprotein) levels are increased during the development of HCC (hepatocellular carcinoma); nonetheless, it can also be produced by non-tumoral hepatocytes in conditions high cell turnover. Our study aims to provide additional data regarding causes elevated patients with liver cirrhosis due hepatitis C virus (HCV) infection. We conducted an observational prospective cohort that included 2068 compensated and chronic genotype 1b The two main inclusion criteria were presence advanced...
Background and Aims: Celiac disease is characterized by an inappropriate T-cell-mediated response to gluten in small bowel genetically predisposed individuals, carriers of the DQ2 and/or DQ8 haplotypes human leukocyte antigen. The aim our study was asses HLA typing adult patients with celiac disease, their first degree relatives a healthy control group.
 Methods: We conducted prospective observational on three cohorts: 117 diagnosed 41 first-degree 57 asymptomatic volunteers. Low...
Background and Aims: Therapeutic targets in ulcerative colitis (UC) have evolved over time from clinical remission to biological endoscopic remission. Histologic remains a debatable outcome due lack of data regarding its impact on long-term evolution. The development histologic activity scores has brought standardization. We aimed identify mucosal markers differentiating histological inflammation UC patients.
 Methods: gene expression levels 84 genes associated with inflammatory bowel...
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is an entity with a growing incidence but only few pharmacological options.In Romania, the prevalence of MASLD has been increasing, while that viral hepatitis decreasing.The purpose this study to compare two supplements for treatment MASLD.Methods: Between January 2020 and May 2022, 90 patients were randomized receive either silymarin 150 mg b.i.d (45 subjects) or essential phospholipids (EPLs) 825 b.i.d.(45 six...
(1) Background: Hypertriglyceridemia (HTG) is a well-known metabolic condition associated with an increased risk of acute pancreatitis. In this study, we tried to establish whether there are any significant disparities concerning recurrence rate, intensive care unit (ICU) admission, hospital (ICU and total) length stay (LoS), morphology, severity age between HTG-induced pancreatitis other known cause (OAP). (2) Methods: The research was retrospective unicentric cohort using information from...
Background and Aims: Ledipasvir/Sofosbuvir (LDV/SOF) with or without Ribavirin (RBV) has shown good results in terms of efficacy safety clinical trials advanced liver cirrhosis, but real-life data are still needed order to confirm this profile. We investigated the LDV/SOF a large Romanian population cirrhosis genotype 1b hepatitis C virus (HCV).
 Methods: analyzed multicentric retrospective cohort enrolling 349 patients decompensated due HCV who received LDV/SOF±RBV 12/24 weeks...
Despite recent discoveries, patients with inflammatory bowel disease (IBD) still face challenges attainment of remission. The objectives the study were to identify characteristics Freiburg Personality Inventory and intensity intestinal disease, comorbidities that could be related personality subjects. Data collected in period 2019–2020 from 46 used nonparametric methods. Compared normative sample, Inhibitedness, Health Concerns, Emotionality scales had significantly higher raw scores. Social...